James N. Ihle
James N. Ihle
Chairman, Department of Biochemistry, St. Jude Children's Research Hospital
Verified email at
Cited by
Cited by
STATs: signal transducers and activators of transcription
JN Ihle
Cell 84 (3), 331-334, 1996
Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted State6 gene
K Shimoda, J van Deursent, MY Sangster, SR Sarawar, RT Carson, ...
Nature 380 (6575), 630-633, 1996
Cytokine receptor signalling
JN Ihle
Nature 377 (6550), 591-594, 1995
Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses
S Teglund, C McKay, E Schuetz, JM Van Deursen, D Stravopodis, ...
Cell 93 (5), 841-850, 1998
Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells
WE Thierfelder, JM van Deursen, K Yamamoto, RA Tripp, SR Sarawar, ...
Nature 382 (6587), 171-174, 1996
JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin
BA Witthuhn, FW Quelle, O Silvennoinen, T Yi, B Tang, O Miura, JN Ihle
Cell 74 (2), 227-236, 1993
Jak2 is essential for signaling through a variety of cytokine receptors
E Parganas, D Wang, D Stravopodis, DJ Topham, JC Marine, S Teglund, ...
Cell 93 (3), 385-395, 1998
Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 β receptor components
N Stahl, TG Boulton, T Farruggella, NY Ip, S Davis, BA Witthuhn, ...
Science 263 (5143), 92-95, 1994
Identification of JAK2 as a growth hormone receptor-associated tyrosine kinase
LS Argetsinger, GS Campbell, X Yang, BA Witthuhn, O Silvennoinen, ...
Cell 74 (2), 237-244, 1993
Jaks and Stats in signaling by the cytokine receptor superfamily
JN Ihle, IM Kerr
Trends in Genetics 11 (2), 69-74, 1995
Gene-marking to trace origin of relapse after autologous bone-marrow transplantation
MK Brenner, DR Rill, RA Krance, JN Ihle, RC Moen, J Mirro, WF Anderson
The Lancet 341 (8837), 85-86, 1993
Interleukin 6 enhancement of interleukin 3-dependent proliferation of multipotential hemopoietic progenitors.
K Ikebuchi, GG Wong, SC Clark, JN Ihle, Y Hirai, M Ogawa
Proceedings of the National Academy of Sciences 84 (24), 9035-9039, 1987
Puma is an essential mediator of p53-dependent and-independent apoptotic pathways
JR Jeffers, E Parganas, Y Lee, C Yang, JL Wang, J Brennan, ...
Cancer cell 4 (4), 321-328, 2003
Biologic properties of homogeneous interleukin 3. I. Demonstration of WEHI-3 growth factor activity, mast cell growth factor activity, p cell-stimulating factor activity …
JN Ihle, J Keller, ST Oroszlan, LE Henderson, TD Copeland, F Fitch, ...
Journal of immunology (Baltimore, Md.: 1950) 131 (1), 282-287, 1983
The JAK‐binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop
H Yasukawa, H Misawa, H Sakamoto, M Masuhara, A Sasaki, T Wakioka, ...
The EMBO journal, 1999
The Stat family in cytokine signaling
JN Ihle
Current opinion in cell biology 13 (2), 211-217, 2001
The protein tyrosine kinase JAK1 complements defects in interferon-α/β and-γ signal transduction
M Müller, J Briscoe, C Laxton, D Guschin, A Ziemiecki, O Silvennoinen, ...
Nature 366 (6451), 129-135, 1993
Mutations at the murine motheaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene
LD Shultz, PA Schweitzer, TV Rajan, T Yi, JN Ihle, RJ Matthews, ...
Cell 73 (7), 1445-1454, 1993
Signaling by the cytokine receptor superfamily: JAKs and STATs
JN Ihle, BA Witthuhn, FW Quelle, K Yamamoto, WE Thierfelder, B Kreider, ...
Trends in biochemical sciences 19 (5), 222-227, 1994
Interaction of IL-2Rβ and γc Chains with Jak1 and Jak3: Implications for XSCID and XCID
SM Russell, JA Johnston, M Noguchi, M Kawamura, CM Bacon, ...
Science 266 (5187), 1042-1045, 1994
The system can't perform the operation now. Try again later.
Articles 1–20