| Suppression of viral infectivity through lethal defection A Grande-Pérez, E Lázaro, P Lowenstein, E Domingo, SC Manrubia Proceedings of the National Academy of Sciences 102 (12), 4448-4452, 2005 | 208 | 2005 |
| Quasispecies dynamics and RNA virus extinction E Domingo, C Escarmís, E Lázaro, SC Manrubia Virus research 107 (2), 129-139, 2005 | 145 | 2005 |
| Resistance of virus to extinction on bottleneck passages: study of a decaying and fluctuating pattern of fitness loss E Lázaro, C Escarmís, J Pérez-Mercader, SC Manrubia, E Domingo Proceedings of The National Academy of Sciences 100 (19), 10830-10835, 2003 | 130 | 2003 |
| High mutation rates, bottlenecks, and robustness of RNA viral quasispecies SC Manrubia, C Escarmís, E Domingo, E Lázaro Gene 347 (2), 273-282, 2005 | 127 | 2005 |
| Molecular intermediates of fitness gain of an RNA virus: characterization of a mutant spectrum by biological and molecular cloning A Arias, E Lázaro, C Escarmís, E Domingo Journal of General Virology 82 (5), 1049-1060, 2001 | 113 | 2001 |
| Analysis of ribavirin mutagenicity in human hepatitis C virus infection S Chevaliez, R Brillet, E Lázaro, C Hézode, JM Pawlotsky Journal of virology 81 (14), 7732-7741, 2007 | 106 | 2007 |
| Population bottlenecks in quasispecies dynamics C Escarmís, E Lázaro, SC Manrubia Quasispecies: concept and implications for virology, 141-170, 2006 | 94 | 2006 |
| Resistance to extinction of low fitness virus subjected to plaque-to-plaque transfers: diversification by mutation clustering C Escarmı́s, G Gómez-Mariano, M Dávila, E Lázaro, E Domingo Journal of molecular biology 315 (4), 647-661, 2002 | 91 | 2002 |
| Foot-and-mouth disease virus evolution: exploring pathways towards virus extinction E Domingo, N Pariente, A Airaksinen, C González-López, S Sierra, ... Foot-and-mouth disease virus, 149-173, 2005 | 74 | 2005 |
| Modeling viral genome fitness evolution associated with serial bottleneck events: evidence of stationary states of fitness E Lázaro, C Escarmís, E Domingo, SC Manrubia Journal of virology 76 (17), 8675-8681, 2002 | 73 | 2002 |
| Pathways to extinction: beyond the error threshold SC Manrubia, E Domingo, E Lázaro Philosophical Transactions of the Royal Society B: Biological Sciences 365 …, 2010 | 71 | 2010 |
| Viral evolution SC Manrubia, E Lázaro Physics of Life Reviews 3 (2), 65-92, 2006 | 67 | 2006 |
| A Sparsomycin-resistant Mutant ofHalobacterium salinariumLacks a Modification at Nucleotide U2603 in the Peptidyl Transferase Centre of 23 S rRNA E Lázaro, C Rodriguez-Fonseca, B Porse, D Ureña, RA Garrett, ... Journal of molecular biology 261 (2), 231-238, 1996 | 60 | 1996 |
| Repeated bottleneck transfers can lead to non-cytocidal forms of a cytopathic virus: implications for viral extinction C Escarmís, E Lázaro, A Arias, E Domingo Journal of molecular biology 376 (2), 367-379, 2008 | 57 | 2008 |
| Beneficial effects of population bottlenecks in an RNA virus evolving at increased error rate C Cases-González, M Arribas, E Domingo, E Lázaro Journal of molecular biology 384 (5), 1120-1129, 2008 | 42 | 2008 |
| Fitness distributions in exponentially growing asexual populations SC Manrubia, E Lázaro, J Pérez-Mercader, C Escarmís, E Domingo Physical review letters 90 (18), 188102, 2003 | 41 | 2003 |
| Biochemical and kinetic characteristics of the interaction of the antitumor antibiotic sparsomycin with prokaryotic and eukaryotic ribosomes E Lazaro, LAGM Van den Broek, A San Felix, HCJ Ottenheijm, ... Biochemistry 30 (40), 9642-9648, 1991 | 35 | 1991 |
| Variable mutation rates as an adaptive strategy in replicator populations M Stich, SC Manrubia, E Lázaro PLoS One 5 (6), e11186, 2010 | 30 | 2010 |
| Lipophilic analogs of sparsomycin as strong inhibitors of protein synthesis and tumor growth: a structure-activity relationship study LAGM Van den Broek, E Lazaro, Z Zylicz, PJ Fennis, FAN Missler, ... Journal of medicinal chemistry 32 (8), 2002-2015, 1989 | 29 | 1989 |
| Adaptation to fluctuating temperatures in an RNA virus is driven by the most stringent selective pressure M Arribas, K Kubota, L Cabanillas, E Lazaro PLoS One 9 (6), e100940, 2014 | 27 | 2014 |
Susanna ManrubiaCentro Nacional de Biotecnología (CSIC), Grupo Interdisciplinar de Sistemas Complejos (GISC), MadridDirección de correo verificada de cnb.csic.es
