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Cahir O'Kane
Cahir O'Kane
Department of Genetics, University of Cambridge
Verified email at gen.cam.ac.uk - Homepage
Title
Cited by
Cited by
Year
Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease
B Ravikumar, C Vacher, Z Berger, JE Davies, S Luo, LG Oroz, F Scaravilli, ...
Nature genetics 36 (6), 585-595, 2004
28172004
Detection in situ of genomic regulatory elements in Drosophila
CJ O'Kane, WJ Gehring
Proceedings of the National Academy of Sciences 84 (24), 9123, 1987
10671987
Targeted expression of tetanus toxin light chain in Drosophila specifically eliminates synaptic transmission and causes behavioral defects
ST Sweeney, K Broadie, J Keane, H Niemann, CJ O'Kane
Neuron 14 (2), 341-351, 1995
10181995
α-Synuclein impairs macroautophagy: implications for Parkinson’s disease
AR Winslow, CW Chen, S Corrochano, A Acevedo-Arozena, DE Gordon, ...
Journal of Cell Biology 190 (6), 1023-1037, 2010
9612010
Novel targets for Huntington's disease in an mTOR-independent autophagy pathway
A Williams, S Sarkar, P Cuddon, EK Ttofi, S Saiki, FH Siddiqi, L Jahreiss, ...
Nature chemical biology 4 (5), 295-305, 2008
9172008
Lysosomal positioning coordinates cellular nutrient responses
VI Korolchuk, S Saiki, M Lichtenberg, FH Siddiqi, EA Roberts, S Imarisio, ...
Nature cell biology 13 (4), 453-460, 2011
9032011
P-element-mediated enhancer detection: a versatile method to study development in Drosophila.
HJ Bellen, CJ O'Kane, C Wilson, U Grossniklaus, RK Pearson, ...
Genes & development 3 (9), 1288, 1989
8481989
Rapamycin alleviates toxicity of different aggregate-prone proteins
Z Berger, B Ravikumar, FM Menzies, LG Oroz, BR Underwood, ...
Human molecular genetics 15 (3), 433, 2006
8262006
Small molecules enhance autophagy and reduce toxicity in Huntington's disease models
S Sarkar, EO Perlstein, S Imarisio, S Pineau, A Cordenier, RL Maglathlin, ...
Nature chemical biology 3 (6), 331-338, 2007
6902007
Associative learning disrupted by impaired Gs signaling in Drosophila mushroom bodies
JB Connolly, IJH Roberts, JD Armstrong, K Kaiser, M Forte, T Tully, ...
Science 274 (5295), 2104, 1996
5751996
Dynein mutations impair autophagic clearance of aggregate-prone proteins
B Ravikumar, A Acevedo-Arozena, S Imarisio, Z Berger, C Vacher, ...
Nature genetics 37 (7), 771-776, 2005
5572005
Rapamycin pre-treatment protects against apoptosis
B Ravikumar, Z Berger, C Vacher, CJ O'Kane, DC Rubinsztein
Human molecular genetics 15 (7), 1209, 2006
5222006
P-element-mediated enhancer detection: an efficient method for isolating and characterizing developmentally regulated genes in Drosophila.
C Wilson, RK Pearson, HJ Bellen, CJ O'Kane, U Grossniklaus, ...
Genes & development 3 (9), 1301, 1989
4921989
Syntaxin and synaptohrevin function downstream of vesicle docking in drosophila
K Broadie, A Prokop, HJ Bellen, CJ O'Kane, KL Schulze, ST Sweeney
Neuron 15 (3), 663-673, 1995
4731995
The DrosDel Collection
E Ryder, F Blows, M Ashburner, R Bautista-Llacer, D Coulson, ...
Genetics 167 (2), 797, 2004
4192004
A rational mechanism for combination treatment of Huntington's disease using lithium and rapamycin
S Sarkar, G Krishna, S Imarisio, S Saiki, CJ O'Kane, DC Rubinsztein
Human molecular genetics 17 (2), 170, 2008
4082008
Complex inhibitory effects of nitric oxide on autophagy
S Sarkar, VI Korolchuk, M Renna, S Imarisio, A Fleming, A Williams, ...
Molecular cell 43 (1), 19-32, 2011
4002011
Hereditary spastic paraplegias: membrane traffic and the motor pathway
C Blackstone, CJ O'Kane, E Reid
Nature Reviews Neuroscience 12 (1), 31-42, 2010
3552010
Rab5 modulates aggregation and toxicity of mutant huntingtin through macroautophagy in cell and fly models of Huntington disease
B Ravikumar, S Imarisio, S Sarkar, CJ O'Kane, DC Rubinsztein
Journal of Cell Science 121 (10), 1649, 2008
3542008
Amphiphysin is necessary for organization of the excitation–contraction coupling machinery of muscles, but not for synaptic vesicle endocytosis in Drosophila
A Razzaq, IM Robinson, HT McMahon, JN Skepper, Y Su, AC Zelhof, ...
Genes & development 15 (22), 2967, 2001
2822001
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