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Lourdes Rueda (Maria Lourdes Rueda Benedé)
Lourdes Rueda (Maria Lourdes Rueda Benedé)
Recursion Pharmaceuticals
Dirección de correo verificada de recursionpharma.com
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Discovery of a first-in-class reversible DNMT1-selective inhibitor with improved tolerability and efficacy in acute myeloid leukemia
MB Pappalardi, K Keenan, M Cockerill, WA Kellner, A Stowell, C Sherk, ...
Nature cancer 2 (10), 1002-1017, 2021
1632021
In vitro and in vivo induction of fetal hemoglobin with a reversible and selective DNMT1 inhibitor
AG Gilmartin, A Groy, ER Gore, C Atkins, ER Long, MN Montoute, Z Wu, ...
Haematologica 106 (7), 1979, 2021
482021
Cyclopropyl carboxamides, a chemically novel class of antimalarial agents identified in a phenotypic screen
LM Sanz, MB Jiménez-Díaz, B Crespo, C De-Cozar, MJ Almela, ...
Antimicrobial agents and chemotherapy 55 (12), 5740-5745, 2011
392011
Cyclopropyl carboxamides: a new oral antimalarial series derived from the Tres Cantos anti-malarial set (TCAMS)
L Rueda, I Castellote, J Castro-Pichel, MJ Chaparro, JC de la Rosa, ...
ACS Medicinal Chemistry Letters 2 (11), 840-844, 2011
382011
Development of Chemical Entities Endowed with Potent Fast-Killing Properties against Plasmodium falciparum Malaria Parasites
AN Matralis, A Malik, M Penzo, I Moreno, MJ Almela, I Camino, B Crespo, ...
Journal of medicinal chemistry 62 (20), 9217-9235, 2019
342019
Structural characterization of dicyanopyridine containing DNMT1-selective, non-nucleoside inhibitors
JR Horton, S Pathuri, K Wong, R Ren, L Rueda, DT Fosbenner, ...
Structure 30 (6), 793-802. e5, 2022
192022
Case study of small molecules as antimalarials: 2-amino-1-phenylethanol (APE) derivatives
MJ Chaparro, J Vidal, I Angulo-Barturen, JM Bueno, J Burrows, ...
ACS Medicinal Chemistry Letters 5 (6), 657-661, 2014
132014
The discovery of novel antimalarial aminoxadiazoles as a promising nonendoperoxide scaffold
E Sandoval, MJ Lafuente-Monasterio, MJ Almela, P Castaneda, ...
Journal of medicinal chemistry 60 (16), 6880-6896, 2017
122017
Discovery of selective, noncovalent small molecule inhibitors of DNMT1 as an alternative to traditional DNA hypomethylating agents
MB Pappalardi, M Cockerill, JL Handler, A Stowell, K Keenan, CS Sherk, ...
Cancer Research 78 (13_Supplement), 2994-2994, 2018
92018
A decade of malaria phenotypic screenings: Key lessons on the discovery and development of new antimalarial drugs
E Fernández, MI Castellote, MJ Chaparro, B Díaz, J Fernández, M Gordo, ...
Annual reports in medicinal chemistry 53, 1-23, 2019
52019
Substituted pyridines as inhibitors of DNMT1
ND Adams, AB Benowitz, MLR BENEDE, KA Evans, DT Fosbenner, ...
US Patent 10,975,056, 2021
12021
Substituted pyridines as inhibitors of DNMT1
ND ADAMS, AB Benowitz, MLR BENEDE, KA Evans, DT Fosbenner, ...
12017
Design and synthesis of aminopyridine containing biaryls reducing c-MYC protein levels in cells
CN Di Marco, L Terrell, R Sanchez, L Rueda, L Shuster, EN Nartey, ...
Bioorganic & Medicinal Chemistry Letters 92, 129385, 2023
2023
Compuestos quimicos
ND Adams, AB Benowitz, MLR Benede, KA Evans, DT Fosbenner, ...
2019
Substituted pyridines as inhibitors of dnmt1
ND ADAMS, AB Benowitz, MLR BENEDE, KA Evans, DT Fosbenner, ...
2019
Discovery of a selective, non-nucleoside small molecule inhibitor of DNA methyltransferase 1 (DNMT1)
B King, A Benowitz, J Briand, C Burt, C Carpenter, M Cockerill, K Evans, ...
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 256, 2018
2018
SUBSTITUTED PYRIDINES AS INHIBITORS OF DNMT1
ML RUEDA BENEDE, ND (US). ADAMS, AB (US). BENOWITZ, ...
2017
SUBSTITUTED PYRIDINES AS INHIBITORS OF DNMT1
ML RUEDA BENEDE, ND (US). ADAMS, AB (US). BENOWITZ, ...
US Patent WO/2017/216,726, 2017
2017
NEW EFFORTS AIMED AT REPLACING ACTS: THE IDENTIFICATION OF NOVEL, DRUG-LIKE, AND FAST-ACTING ANTIMALARIAL COMPOUNDS FROM A PHENOTYPIC SCREENING
L Rueda
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE 93 (4), 295-295, 2015
2015
Scaffold based analytics enabling hit to lead decisions by visualizing chemical series linked across large datasets
ACS Conference, 2015
2015
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Artículos 1–20