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Nathan Rollins
Nathan Rollins
Seismic Therapeutics
Dirección de correo verificada de seismictx.com
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Inferring protein 3D structure from deep mutation scans
NJ Rollins, KP Brock, FJ Poelwijk, MA Stiffler, NP Gauthier, C Sander, ...
Nature genetics 51 (7), 1170-1176, 2019
1482019
Multiplexed measurement of variant abundance and activity reveals VKOR topology, active site and human variant impact
MA Chiasson, NJ Rollins, JJ Stephany, KA Sitko, KA Matreyek, M Verby, ...
elife 9, e58026, 2020
602020
Learning from prepandemic data to forecast viral escape
NN Thadani, S Gurev, P Notin, N Youssef, NJ Rollins, D Ritter, C Sander, ...
Nature, 1-8, 2023
35*2023
PDBe-KB: collaboratively defining the biological context of structural data
Nucleic acids research 50 (D1), D534-D542, 2022
322022
Exploring targeting peptide-shell interactions in encapsulin nanocompartments
WJ Altenburg, N Rollins, PA Silver, TW Giessen
Scientific reports 11 (1), 4951, 2021
282021
Chimeric fatty acyl-acyl carrier protein thioesterases provide mechanistic insight into enzyme specificity and expression
M Ziesack, N Rollins, A Shah, B Dusel, G Webster, PA Silver, JC Way
Applied and environmental microbiology 84 (10), e02868-17, 2018
282018
ProteinGym: large-scale benchmarks for protein fitness prediction and design
P Notin, A Kollasch, D Ritter, L Van Niekerk, S Paul, H Spinner, N Rollins, ...
Advances in Neural Information Processing Systems 36, 2024
18*2024
Natural and designed proteins inspired by extremotolerant organisms can form condensates and attenuate apoptosis in human cells
MT Veling, DT Nguyen, NN Thadani, ME Oster, NJ Rollins, KP Brock, ...
ACS synthetic biology 11 (3), 1292-1302, 2022
132022
Protein design using structure-based residue preferences
D Ding, AY Shaw, S Sinai, N Rollins, N Prywes, DF Savage, MT Laub, ...
Nature Communications 15 (1), 1639, 2024
11*2024
MaveDB v2: a curated community database with over three million variant effects from multiplexed functional assays
A Rubin, J Min, N Rollins, E Da, D Esposito, M Harrington, J Stone, ...
bioRxiv, 2021
112021
Machine learning for functional protein design
P Notin, N Rollins, Y Gal, C Sander, D Marks
Nature Biotechnology 42 (2), 216-228, 2024
82024
3D protein structure from genetic epistasis experiments
NJ Rollins, KP Brock, FJ Poelwijk, MA Stiffler, NP Gauthier, C Sander, ...
bioRxiv, 320721, 2018
82018
High-Content Screening and Computational Prediction Reveal Viral Genes That Suppress the Innate Immune Response
TL Ng, EJ Olson, TY Yoo, HS Weiss, Y Koide, PD Koch, NJ Rollins, ...
Msystems 7 (2), e01466-21, 2022
42022
Removing bias in sequence models of protein fitness
A Shaw, H Spinner, S Gurev, JE Shin, N Rollins, D Marks
bioRxiv, 2023
32023
Mammalian Cells Engineered To Produce New Steroids
ES Spady, TP Wyche, NJ Rollins, J Clardy, JC Way, PA Silver
ChemBioChem 19 (17), 1827-1833, 2018
22018
High-content screening of coronavirus genes for innate immune suppression reveals enhanced potency of SARS-CoV-2 proteins
EJ Olson, DM Brown, TZ Chang, L Ding, TL Ng, HS Weiss, Y Koide, ...
bioRxiv, 2021.03. 02.433434, 2021
12021
Preclinical Pharmacology of S-1117, a Novel Engineered Fc-fused IgG Cleaving Enzyme, for Chronic Treatment of Autoantibody-mediated Diseases (P4-14.018)
I Mascanfroni, J Manasson, A Pellerin, L Sanmarco, J Anderson, N Rollins, ...
Neurology 102 (17_supplement_1), 6869, 2024
2024
The promise of machine learning: using Seismic’s IMPACT platform to design IgG cleaving enzymes for chronic treatment of autoimmune diseases
A Pellerin, J Anderson, N Rollins, L Sanmarco, A Newton, N Le, J Shin, ...
The Journal of Immunology 210 (1_Supplement), 85.13-85.13, 2023
2023
In vitro assay development to assess successful removal of T and B cell epitopes through Seismic’s IMPACT platform
AP Newton, A Pellerin, J Anderson, N Rollins, M Hollfelder, R Peckner, ...
The Journal of Immunology 210 (1_Supplement), 85.16-85.16, 2023
2023
Anti-apoptotic condensates of extremotolerance-related proteins
D Nguyen, M Veling, N Thadani, M Oster, N Rollins, K Brock, N Bethel, ...
APS March Meeting Abstracts 2022, Y06. 007, 2022
2022
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