Chaim A Schramm
Chaim A Schramm
Staff Scientist, Vaccine Research Center, NIAID, NIH
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Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus
HX Liao, R Lynch, T Zhou, F Gao, SM Alam, SD Boyd, AZ Fire, KM Roskin, ...
Nature 496 (7446), 469-476, 2013
Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies
NA Doria-Rose, CA Schramm, J Gorman, PL Moore, JN Bhiman, ...
Nature 509 (7498), 55-62, 2014
Multidonor analysis reveals structural elements, genetic determinants, and maturation pathway for HIV-1 neutralization by VRC01-class antibodies
T Zhou, J Zhu, X Wu, S Moquin, B Zhang, P Acharya, IS Georgiev, ...
Immunity 39 (2), 245-258, 2013
Identification of a CD4-Binding-Site Antibody to HIV that Evolved Near-Pan Neutralization Breadth
J Huang, BH Kang, E Ishida, T Zhou, T Griesman, Z Sheng, F Wu, ...
Immunity 45 (5), 1108-1121, 2016
Maturation Pathway from Germline to Broad HIV-1 Neutralizer of a CD4-Mimic Antibody
M Bonsignori, T Zhou, Z Sheng, L Chen, F Gao, MG Joyce, G Ozorowski, ...
Cell 165 (2), 449-463, 2016
Maturation and diversity of the VRC01-antibody lineage over 15 years of chronic HIV-1 infection
X Wu, Z Zhang, CA Schramm, MG Joyce, Y Do Kwon, T Zhou, Z Sheng, ...
Cell 161 (3), 470-485, 2015
Viral variants that initiate and drive maturation of V1V2-directed HIV-1 broadly neutralizing antibodies
JN Bhiman, C Anthony, NA Doria-Rose, O Karimanzira, CA Schramm, ...
Nature medicine, 2015
New member of the V1V2-directed CAP256-VRC26 lineage that shows increased breadth and exceptional potency
NA Doria-Rose, JN Bhiman, RS Roark, CA Schramm, J Gorman, ...
Journal of virology 90 (1), 76-91, 2016
Knowledge-based potential for positioning membrane-associated structures and assessing residue-specific energetic contributions
CA Schramm, BT Hannigan, JE Donald, C Keasar, JG Saven, ...
Structure 20 (5), 924-935, 2012
Reproducibility and reuse of adaptive immune receptor repertoire data
F Breden, ET Luning Prak, B Peters, F Rubelt, CA Schramm, CE Busse, ...
Frontiers in immunology 8, 1418, 2017
The Membrane-and Soluble-Protein Helix-Helix Interactome: Similar Geometry via Different Interactions
SQ Zhang, DW Kulp, CA Schramm, M Mravic, I Samish, WF DeGrado
Structure 23 (3), 527-541, 2015
Gene-specific substitution profiles describe the types and frequencies of amino acid changes during antibody somatic hypermutation
Z Sheng, CA Schramm, R Kong, JC Mullikin, JR Mascola, PD Kwong, ...
Frontiers in Immunology 8, 2017
SONAR: a high-throughput pipeline for inferring antibody ontogenies from longitudinal sequencing of B cell transcripts
CA Schramm, Z Sheng, Z Zhang, JR Mascola, PD Kwong, L Shapiro
Frontiers in immunology 7, 372, 2016
Design of Nanoparticulate Group 2 Influenza Virus Hemagglutinin Stem Antigens That Activate Unmutated Ancestor B Cell Receptors of Broadly Neutralizing Antibody Lineages
KS Corbett, SM Moin, HM Yassine, A Cagigi, M Kanekiyo, ...
mBio 10 (1), e02810-18, 2019
Activation dynamics and immunoglobulin evolution of pre-existing and newly generated human memory B cell responses to influenza hemagglutinin
SF Andrews, MJ Chambers, CA Schramm, J Plyler, JE Raab, M Kanekiyo, ...
Immunity 51 (2), 398-410. e5, 2019
Inferred allelic variants of immunoglobulin receptor genes: a system for their evaluation, documentation, and naming
M Ohlin, C Scheepers, M Corcoran, WD Lees, CE Busse, D Bagnara, ...
Frontiers in immunology 10, 435, 2019
Longitudinal analysis reveals early development of three MPER-directed neutralizing antibody lineages from an HIV-1-infected individual
SJ Krebs, YD Kwon, CA Schramm, WH Law, G Donofrio, KH Zhou, S Gift, ...
Immunity 50 (3), 677-691. e13, 2019
Effects of Darwinian selection and mutability on rate of broadly neutralizing antibody evolution during HIV-1 infection
Z Sheng, CA Schramm, M Connors, L Morris, JR Mascola, PD Kwong, ...
PLoS computational biology 12 (5), e1004940, 2016
Antibodyomics: bioinformatics technologies for understanding B‐cell immunity to HIV‐1
PD Kwong, GY Chuang, BJ DeKosky, T Gindin, IS Georgiev, T Lemmin, ...
Immunological Reviews 275 (1), 108-128, 2017
AIRR Community Standardized Representations for Annotated Immune Repertoires
JA Vander Heiden, S Marquez, N Marthandan, SAC Bukhari, CE Busse, ...
Frontiers in immunology 9, 2206, 2018
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