| Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional … WS Redfern, L Carlsson, AS Davis, WG Lynch, IL MacKenzie, ... Cardiovascular research 58 (1), 32-45, 2003 | 1631 | 2003 |
| Instability and triangulation of the action potential predict serious proarrhythmia, but action potential duration prolongation is antiarrhythmic LM Hondeghem, L Carlsson, G Duker Circulation 103 (15), 2004-2013, 2001 | 585 | 2001 |
| QTU-prolongation and torsades de pointes induced by putative class III antiarrhythmic agents in the rabbit: etiology and interventions L Carlsson, O Almgren, G Duker Journal of cardiovascular pharmacology 16 (2), 276-285, 1990 | 273 | 1990 |
| Innovative approaches to anti-arrhythmic drug therapy S Nattel, L Carlsson Nature reviews Drug discovery 5 (12), 1034-1049, 2006 | 272 | 2006 |
| Proarrhythmic effects of the class III agent almokalant: importance of infusion rate, QT dispersion, and early afterdepolarisations L Carlsson, C Abrahamsson, B Andersson, G Duker, G Schiller-Linhardt Cardiovascular Research 27 (12), 2186-2193, 1993 | 246 | 1993 |
| Novel molecular targets for atrial fibrillation therapy D Dobrev, L Carlsson, S Nattel Nature reviews Drug discovery 11 (4), 275-291, 2012 | 218 | 2012 |
| Electrophysiological characterization of the prokinetic agents cisapride and mosapride in vivo and in vitro: implications for proarrhythmic potential? L Carlsson, GJ Amos, B Andersson, L Drews, G Duker, G Wadstedt Journal of Pharmacology and Experimental Therapeutics 282 (1), 220-227, 1997 | 210 | 1997 |
| Intradermal delivery of modified mRNA encoding VEGF-A in patients with type 2 diabetes LM Gan, M Lagerström-Fermér, LG Carlsson, C Arfvidsson, AC Egnell, ... Nature communications 10 (1), 871, 2019 | 167 | 2019 |
| Antiarrhythmic effects of potassium channel openers in rhythm abnormalities related to delayed repolarization. L Carlsson, C Abrahamsson, L Drews, G Duker Circulation 85 (4), 1491-1500, 1992 | 162 | 1992 |
| Biocompatible, purified VEGF-A mRNA improves cardiac function after intracardiac injection 1 week post-myocardial infarction in swine L Carlsson, JC Clarke, C Yen, F Gregoire, T Albery, M Billger, AC Egnell, ... Molecular Therapy-Methods & Clinical Development 9, 330-346, 2018 | 144 | 2018 |
| Protective effects of ticagrelor on myocardial injury after infarction G Vilahur, M Gutiérrez, L Casani, L Varela, A Capdevila, G Pons-Lladó, ... Circulation 134 (22), 1708-1719, 2016 | 137 | 2016 |
| Azd7009: a new antiarrhythmic drug with predominant effects on the atria effectively terminates and prevents reinduction of atrial fibrillation and flutter in the sterile … RN Goldstein, C Khrestian, L Carlsson, AL Waldo Journal of cardiovascular electrophysiology 15 (12), 1444-1450, 2004 | 119 | 2004 |
| Methods of collecting and evaluating non-clinical cardiac electrophysiology data in the pharmaceutical industry: results of an international survey TG Hammond, L Carlsson, AS Davis, WG Lynch, I MacKenzie, ... Cardiovascular Research 49 (4), 741-750, 2001 | 117 | 2001 |
| Modified VEGF-A mRNA induces sustained multifaceted microvascular response and accelerates diabetic wound healing N Sun, B Ning, KM Hansson, AC Bruce, SA Seaman, C Zhang, M Rikard, ... Scientific reports 8 (1), 17509, 2018 | 92 | 2018 |
| In vitro and in vivo models for testing arrhythmogenesis in drugs L Carlsson Journal of internal medicine 259 (1), 70-80, 2006 | 91 | 2006 |
| Atrial-selective effects of chronic amiodarone in the management of atrial fibrillation A Burashnikov, JM Di Diego, S Sicouri, M Ferreiro, L Carlsson, ... Heart Rhythm 5 (12), 1735-1742, 2008 | 90 | 2008 |
| Induction of rhythm abnormalities in the fetal rat heart. A tentative mechanism for the embryotoxic effect of the class III antiarrhythmic agent almokalant C Abrahamsson, M Palmer, B Ljung, G Duker, C Bäärnhielm, L Carlsson, ... Cardiovascular research 28 (3), 337-344, 1994 | 82 | 1994 |
| Blocking characteristics of hERG, hNav1. 5, and hKvLQT1/hminK after administration of the novel anti‐arrhythmic compound AZD7009 F Persson, L Carlsson, G Duker, I Jacobson Journal of cardiovascular electrophysiology 16 (3), 329-341, 2005 | 75 | 2005 |
| Beat-by-beat QT interval variability, but not QT prolongation per se, predicts drug-induced torsades de pointes in the anaesthetised methoxamine-sensitized rabbit I Jacobson, L Carlsson, G Duker Journal of pharmacological and toxicological methods 63 (1), 40-46, 2011 | 65 | 2011 |
| Functional effects of the late sodium current inhibition by AZD7009 and lidocaine in rabbit isolated atrial and ventricular tissue and Purkinje fibre F Persson, B Andersson, G Duker, I Jacobson, L Carlsson European journal of pharmacology 558 (1-3), 133-143, 2007 | 63 | 2007 |
