| Natural flavonoids as antidiabetic agents. The binding of gallic and ellagic acids to glycogen phosphorylase b E Kyriakis, GA Stravodimos, AL Kantsadi, DSM Chatzileontiadou, ... FEBS letters 589 (15), 1787-1794, 2015 | 63 | 2015 |
| Biochemical and biological assessment of the inhibitory potency of extracts from vinification byproducts of Vitis vinifera extracts against glycogen phosphorylase AL Kantsadi, A Apostolou, S Theofanous, GA Stravodimos, E Kyriakis, ... Food and chemical toxicology 67, 35-43, 2014 | 58 | 2014 |
| Phytogenic polyphenols as glycogen phosphorylase inhibitors: the potential of triterpenes and flavonoids for glycaemic control in type 2 diabetes G A Stravodimos, B A Chetter, E Kyriakis, A L Kantsadi, ... Current medicinal chemistry 24 (4), 384-403, 2017 | 48 | 2017 |
| A multidisciplinary study of 3-(β-d-glucopyranosyl)-5-substituted-1, 2, 4-triazole derivatives as glycogen phosphorylase inhibitors: computation, synthesis, crystallography and … S Kun, J Begum, E Kyriakis, ECV Stamati, TA Barkas, E Szennyes, ... European Journal of Medicinal Chemistry 147, 266-278, 2018 | 31 | 2018 |
| Probing the β-pocket of the active site of human liver glycogen phosphorylase with 3-(C-β-d-glucopyranosyl)-5-(4-substituted-phenyl)-1, 2, 4-triazole inhibitors E Kyriakis, TGA Solovou, S Kun, K Czifrák, B Szőcs, L Juhász, É Bokor, ... Bioorganic chemistry 77, 485-493, 2018 | 27 | 2018 |
| Nanomolar Inhibitors of Glycogen Phosphorylase Based on β-d-Glucosaminyl Heterocycles: A Combined Synthetic, Enzyme Kinetic, and Protein Crystallography … E Bokor, E Kyriakis, TGA Solovou, C Koppány, AL Kantsadi, KE Szabó, ... Journal of Medicinal Chemistry 60 (22), 9251-9262, 2017 | 24 | 2017 |
| van der Waals interactions govern C-β-d-glucopyranosyl triazoles’ nM inhibitory potency in human liver glycogen phosphorylase AL Kantsadi, GA Stravodimos, E Kyriakis, DSM Chatzileontiadou, ... Journal of structural biology 199 (1), 57-67, 2017 | 20 | 2017 |
| Structural and electrophysiological basis for the modulation of KCNQ1 channel currents by ML277 K Willegems, J Eldstrom, E Kyriakis, F Ataei, H Sahakyan, Y Dou, S Russo, ... Nature Communications 13 (1), 1-17, 2022 | 19 | 2022 |
| Glucopyranosylidene-Spiro-Imidazolinones, a New Ring System: Synthesis and Evaluation as Glycogen Phosphorylase Inhibitors by Enzyme Kinetics and X-Ray Crystallography KE Szabó, E Kyriakis, AMG Psarra, AG Karra, Á Sipos, T Docsa, ... Journal of medicinal chemistry 62 (13), 6116-6136, 2019 | 16 | 2019 |
| Synthetic flavonoid derivatives targeting the glycogen phosphorylase inhibitor site: QM/MM-PBSA motivated synthesis of substituted 5, 7-dihydroxyflavones, crystallography, in … BA Chetter, E Kyriakis, D Barr, AG Karra, E Katsidou, SM Koulas, ... Bioorganic Chemistry 102, 104003, 2020 | 14 | 2020 |
| High consistency of structure-based design and X-ray crystallography: Design, synthesis, kinetic evaluation and crystallographic binding mode determination of biphenyl-N-acyl-β … T Fischer, SM Koulas, AS Tsagkarakou, E Kyriakis, GA Stravodimos, ... Molecules 24 (7), 1322, 2019 | 14 | 2019 |
| Glycogen phosphorylase revisited: extending the resolution of the R‐and T‐state structures of the free enzyme and in complex with allosteric activators DD Leonidas, SE Zographos, KE Tsitsanou, VT Skamnaki, G Stravodimos, ... Acta Crystallographica Section F: Structural Biology Communications 77 (9 …, 2021 | 13 | 2021 |
| Affinity crystallography reveals the bioactive compounds of industrial juicing byproducts of Punica granatum for glycogen phosphorylase GA Stravodimos, AL Kantsadi, A Apostolou, E Kyriakis, VN Kafaski-Kanelli, ... Current drug discovery technologies 15 (1), 41-53, 2018 | 8 | 2018 |
| The architecture of hydrogen and sulfur σ-hole interactions explain differences in the inhibitory potency of C-β-d-glucopyranosyl thiazoles, imidazoles and an N-β-d … E Kyriakis, AG Karra, O Papaioannou, T Solovou, VT Skamnaki, ... Bioorganic & Medicinal Chemistry 28 (1), 115196, 2020 | 6 | 2020 |
| Mutagenesis of a Lotus japonicus GSK3β/Shaggy-like kinase reveals functionally conserved regulatory residues TGA Solovou, C Garagounis, E Kyriakis, C Bobas, GE Papadopoulos, ... Phytochemistry 186, 112707, 2021 | 4 | 2021 |
| Structure activity relationship of the binding of p-coumaroyl glucose to glycogen phosphorylase and its effect on hepatic cell metabolic pathways AS Tsagkarakou, SA Chasapi, SM Koulas, I Tsialtas, E Kyriakis, ... European Journal of Medicinal Chemistry Reports, 100011, 2021 | 3 | 2021 |
