Aurora Martinez
Aurora Martinez
Professor ved University of Bergen
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cAMP analog mapping of Epac1 and cAMP kinase discriminating analogs demonstrate that Epac and cAMP kinase act synergistically to promote PC-12 cell neurite extension
AE Christensen, F Selheim, J de Rooij, S Dremier, F Schwede, KK Dao, ...
Journal of Biological Chemistry 278 (37), 35394-35402, 2003
Crystal structure of the catalytic domain of human phenylalanine hydroxylase reveals the structural basis for phenylketonuria.
H Erlandsen, F Fusetti, A Martinez, E Hough, T Flatmark, RC Stevens
Nature structural biology 4 (12), 995, 1997
Expression of recombinant human phenylalanine hydroxylase as fusion protein in Escherichia coli circumvents proteolytic degradation by host cell proteases. Isolation and …
A Martinez, PM Knappskog, S Olafsdottir, AP Døskeland, HG Eiken, ...
Biochemical Journal 306 (2), 589-597, 1995
Correction of kinetic and stability defects by tetrahydrobiopterin in phenylketonuria patients with certain phenylalanine hydroxylase mutations
H Erlandsen, AL Pey, A Gámez, B Pérez, LR Desviat, C Aguado, R Koch, ...
Proceedings of the National Academy of Sciences 101 (48), 16903-16908, 2004
Predicted effects of missense mutations on native-state stability account for phenotypic outcome in phenylketonuria, a paradigm of misfolding diseases
AL Pey, F Stricher, L Serrano, A Martinez
The American Journal of Human Genetics 81 (5), 1006-1024, 2007
Epac1 and cAMP-dependent protein kinase holoenzyme have similar cAMP affinity, but their cAMP domains have distinct structural features and cyclic nucleotide recognition
KK Dao, K Teigen, R Kopperud, E Hodneland, F Schwede, ...
Journal of Biological Chemistry 281 (30), 21500-21511, 2006
Identification of pharmacological chaperones as potential therapeutic agents to treat phenylketonuria
AL Pey, M Ying, N Cremades, A Velazquez-Campoy, T Scherer, B Thöny, ...
The Journal of clinical investigation 118 (8), 2858-2867, 2008
Purification and characterization of two trypsin-like enzymes from the digestive tract of anchovy Engraulis encrasicholus.
A Martínez, RL Olsen, JL Serra
Comparative biochemistry and physiology. B, Comparative biochemistry 91 (4), 677, 1988
Mechanisms underlying responsiveness to tetrahydrobiopterin in mild phenylketonuria mutations
AL Pey, B Pérez, LR Desviat, MA Martínez, C Aguado, H Erlandsen, ...
Human mutation 24 (5), 388-399, 2004
The 14-3-3 proteins in regulation of cellular metabolism
R Kleppe, A Martinez, SO Døskeland, J Haavik
Seminars in cell & developmental biology 22 (7), 713-719, 2011
Recombinant human tyrosine hydroxylase isozymes: Reconstitution with iron and inhibitory effect of other metal ions
European Journal of biochemistry 199 (2), 371-378, 1991
Structure/function relationships in human phenylalanine hydroxylase: effect of terminal deletions on the oligomerization, activation and cooperativity of substrate binding to …
PM Knappskog, T Flatmark, JM Aarden, J Haavik, A Martínez
European journal of biochemistry 242 (3), 813-821, 1996
L-phenylalanine binding and domain organization in human phenylalanine hydroxylase: a differential scanning calorimetry study
M Thórólfsson, B Ibarra-Molero, P Fojan, SB Petersen, JM Sanchez-Ruiz, ...
Biochemistry 41 (24), 7573-7585, 2002
Phenylalanine hydroxylase: function, structure, and regulation
MI Flydal, A Martinez
IUBMB life 65 (4), 341-349, 2013
Principal component and normal mode analysis of proteins; a quantitative comparison using the GroEL subunit
L Skjaerven, A Martinez, N Reuter
Proteins: Structure, Function, and Bioinformatics 79 (1), 232-243, 2011
Allosteric mechanisms in ACT domain containing enzymes involved in amino acid metabolism
JS Liberles, M Thórólfsson, A Martinez
Amino acids 28 (1), 1-12, 2005
Conformational properties and stability of tyrosine hydroxylase studied by infrared spectroscopy EFFECT OF IRON/CATECHOLAMINE BINDING AND PHOSPHORYLATION
A Martínez, J Haavik, T Flatmark, JLR Arrondo, A Muga
Journal of Biological Chemistry 271 (33), 19737-19742, 1996
Partial characterization and three‐dimensional‐structural localization of eight mutations in exon 7 of the human phenylalanine hydroxylase gene associated with phenylketonuria
E Bjørgo, PM Knappskog, A Martinez, RC Stevens, T Flatmark
European journal of biochemistry 257 (1), 1-10, 1998
Blunted epidermal L-tryptophan metabolism in vitiligo affects immune response and ROS scavenging by Fenton chemistry, part 1: Epidermal H2O2/ONOO(-)-mediated stress abrogates …
RH Schallreuter KU, Salem MA, Gibbons NC, Martinez A, Slominski R, Lüdemann J
FASEB J. 26 (6), 2457-70, 2012
Structural and functional properties of isocitrate dehydrogenase from the psychrophilic bacterium Desulfotalea psychrophila reveal a cold-active enzyme with an unusual high …
AE Fedøy, N Yang, A Martinez, HKS Leiros, IH Steen
Journal of Molecular Biology 372 (1), 130-149, 2007
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