| Why do hubs tend to be essential in protein networks? X He, J Zhang PLoS genetics 2 (6), e88, 2006 | 821 | 2006 |
| Rapid subfunctionalization accompanied by prolonged and substantial neofunctionalization in duplicate gene evolution X He, J Zhang Genetics 169 (2), 1157-1164, 2005 | 761 | 2005 |
| Toward a molecular understanding of pleiotropy X He, J Zhang Genetics 173 (4), 1885-1891, 2006 | 230 | 2006 |
| RNA sequencing shows no dosage compensation of the active X-chromosome Y Xiong, X Chen, Z Chen, X Wang, S Shi, X Wang, J Zhang, X He Nature genetics 42 (12), 1043-1047, 2010 | 214 | 2010 |
| Prevalent positive epistasis in Escherichia coli and Saccharomyces cerevisiae metabolic networks X He, W Qian, Z Wang, Y Li, J Zhang Nature genetics 42 (3), 272-276, 2010 | 157 | 2010 |
| The reverse evolution from multicellularity to unicellularity during carcinogenesis H Chen, F Lin, K Xing, X He Nature communications 6 (1), 6367, 2015 | 143 | 2015 |
| The reverse evolution from multicellularity to unicellularity during carcinogenesis H Chen, F Lin, K Xing, X He Nature communications 6 (1), 6367, 2015 | 143 | 2015 |
| Significant impact of protein dispensability on the instantaneous rate of protein evolution J Zhang, X He Molecular biology and evolution 22 (4), 1147-1155, 2005 | 135 | 2005 |
| Gene complexity and gene duplicability X He, J Zhang Current Biology 15 (11), 1016-1021, 2005 | 130 | 2005 |
| Expression reduction in mammalian X chromosome evolution refutes Ohno’s hypothesis of dosage compensation F Lin, K Xing, J Zhang, X He Proceedings of the National Academy of Sciences 109 (29), 11752-11757, 2012 | 121 | 2012 |
| Nucleosomes suppress spontaneous mutations base-specifically in eukaryotes X Chen, Z Chen, H Chen, Z Su, J Yang, F Lin, S Shi, X He Science 335 (6073), 1235-1238, 2012 | 106 | 2012 |
| Higher duplicability of less important genes in yeast genomes X He, J Zhang Molecular biology and evolution 23 (1), 144-151, 2006 | 103 | 2006 |
| The convergent cancer evolution toward a single cellular destination H Chen, X He Molecular biology and evolution 33 (1), 4-12, 2016 | 70 | 2016 |
| Measuring the evolutionary rate of protein–protein interaction W Qian, X He, E Chan, H Xu, J Zhang Proceedings of the National Academy of Sciences 108 (21), 8725-8730, 2011 | 68 | 2011 |
| The nonessentiality of essential genes in yeast provides therapeutic insights into a human disease P Chen, D Wang, H Chen, Z Zhou, X He Genome research 26 (10), 1355-1362, 2016 | 47 | 2016 |
| On the low reproducibility of cancer studies H Wen, HY Wang, X He, CI Wu National science review 5 (5), 619-624, 2018 | 44 | 2018 |
| Biosynthetic energy cost for amino acids decreases in cancer evolution H Zhang, Y Wang, J Li, H Chen, X He, H Zhang, H Liang, J Lu Nature communications 9 (1), 4124, 2018 | 35 | 2018 |
| On the founder effect in COVID-19 outbreaks: how many infected travelers may have started them all? Y Ruan, Z Luo, X Tang, G Li, H Wen, X He, X Lu, J Lu, CI Wu National Science Review 8 (1), nwaa246, 2021 | 31 | 2021 |
| Transcriptional reprogramming and backup between duplicate genes: is it a genomewide phenomenon? X He, J Zhang Genetics 172 (2), 1363-1367, 2006 | 29 | 2006 |
| Reduced intrinsic DNA curvature leads to increased mutation rate C Duan, Q Huan, X Chen, S Wu, LB Carey, X He, W Qian Genome biology 19, 1-12, 2018 | 27 | 2018 |
Jianzhi ZhangProfessor of Ecology and Evolutionary Biology, University of MichiganVerified email at umich.edu
