Christopher J Cheng
Christopher J Cheng
Verve Therapeutics
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MicroRNA silencing for cancer therapy targeted to the tumour microenvironment
CJ Cheng, R Bahal, IA Babar, Z Pincus, F Barrera, C Liu, A Svoronos, ...
Nature 518 (7537), 107, 2015
Nanoparticle-based therapy in an in vivo microRNA-155 (miR-155)-dependent mouse model of lymphoma
IA Babar, CJ Cheng, CJ Booth, X Liang, JB Weidhaas, WM Saltzman, ...
Proceedings of the National Academy of Sciences 109 (26), E1695-E1704, 2012
In vivo CRISPR base editing of PCSK9 durably lowers cholesterol in primates
K Musunuru, AC Chadwick, T Mizoguchi, SP Garcia, JE DeNizio, ...
Nature 593 (7859), 429-434, 2021
A holistic approach to targeting disease with polymeric nanoparticles
CJ Cheng, GT Tietjen, JK Saucier-Sawyer, WM Saltzman
Nature reviews Drug discovery 14 (4), 239-247, 2015
Biodegradable poly(amine-co-ester) terpolymers for targeted gene delivery
J Zhou, J Liu, CJ Cheng, TR Patel, CE Weller, JM Piepmeier, Z Jiang, ...
Nature materials 11 (1), 82, 2012
MiR-34a silences c-SRC to attenuate tumor growth in triple-negative breast cancer
BD Adams, VB Wali, CJ Cheng, S Inukai, CJ Booth, S Agarwal, DL Rimm, ...
Cancer research 76 (4), 927-939, 2016
In vivo correction of anaemia in β-thalassemic mice by γPNA-mediated gene editing with nanoparticle delivery
R Bahal, NA McNeer, E Quijano, Y Liu, P Sulkowski, A Turchick, YC Lu, ...
Nature communications 7, 13304, 2016
Enhanced siRNA delivery into cells by exploiting the synergy between targeting ligands and cell-penetrating peptides
CJ Cheng, WM Saltzman
Biomaterials 32 (26), 6194-6203, 2011
Polymer nanoparticle-mediated delivery of microRNA inhibition and alternative splicing
CJ Cheng, WM Saltzman
Molecular pharmaceutics 9 (5), 1481-1488, 2012
Surface modified poly (β amino ester)-containing nanoparticles for plasmid DNA delivery
RJ Fields, CJ Cheng, E Quijano, C Weller, N Kristofik, N Duong, ...
Journal of Controlled Release 164 (1), 41-48, 2012
miR-155 is essential for inflammation-induced hippocampal neurogenic dysfunction
ME Woodbury, RW Freilich, CJ Cheng, H Asai, S Ikezu, JD Boucher, ...
Journal of Neuroscience 35 (26), 9764-9781, 2015
Optimization of mRNA untranslated regions for improved expression of therapeutic mRNA
KH Asrani, JD Farelli, MR Stahley, RL Miller, CJ Cheng, RR Subramanian, ...
RNA biology 15 (6), 756-762, 2018
Systemic delivery of triplex-forming PNA and donor DNA by nanoparticles mediates site-specific genome editing of human hematopoietic cells in vivo
NA McNeer, EB Schleifman, A Cuthbert, M Brehm, A Jackson, C Cheng, ...
Gene therapy 20 (6), 658, 2013
Systemic delivery of blood–brain barrier-targeted polymeric nanoparticles enhances delivery to brain tissue
JK Saucier-Sawyer, Y Deng, YE Seo, CJ Cheng, J Zhang, E Quijano, ...
Journal of drug targeting 23 (7-8), 736-749, 2015
Sustained delivery of proangiogenic microRNA-132 by nanoparticle transfection improves endothelial cell transplantation
J Devalliere, WG Chang, JW Andrejecsk, P Abrahimi, CJ Cheng, ...
The FASEB Journal 28 (2), 908-922, 2014
The duality of oncomiR addiction in the maintenance and treatment of cancer
CJ Cheng, FJ Slack
Cancer journal (Sudbury, Mass.) 18 (3), 232, 2012
Nanoparticles for urothelium penetration and delivery of the histone deacetylase inhibitor belinostat for treatment of bladder cancer
DT Martin, CJ Hoimes, HZ Kaimakliotis, CJ Cheng, K Zhang, J Liu, ...
Nanomedicine: Nanotechnology, Biology and Medicine 9 (8), 1124-1134, 2013
Canonical and non-canonical barriers facing antimiR cancer therapeutics
C J Cheng, W Mark Saltzman, F J Slack
Current medicinal chemistry 20 (29), 3582-3593, 2013
A “top-down” approach to actuate poly (amine-co-ester) terpolymers for potent and safe mRNA delivery
Y Jiang, A Gaudin, J Zhang, T Agarwal, E Song, AC Kauffman, GT Tietjen, ...
Biomaterials 176, 122-130, 2018
Regeneration of mammalian cochlear and vestibular hair cells through Hes1/Hes5 modulation with siRNA
X Du, W Li, X Gao, MB West, WM Saltzman, CJ Cheng, C Stewart, ...
Hearing research 304, 91-110, 2013
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