Head of HIV-1 Molecular Epidemiology Laboratory, IRYCIS-Hospital Ramon y Cajal, Madrid, Spain
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Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: results of a global collaboration
R Kantor, DA Katzenstein, B Efron, AP Carvalho, B Wynhoven, P Cane, ...
PLoS medicine 2 (4), e112, 2005
Global and regional molecular epidemiology of HIV-1, 1990–2015: a systematic review, global survey, and trend analysis
J Hemelaar, R Elangovan, J Yun, L Dickson-Tetteh, I Fleminger, S Kirtley, ...
The Lancet infectious diseases 19 (2), 143-155, 2019
Pol gene quasispecies of human immunodeficiency virus: mutations associated with drug resistance in virus from patients undergoing no drug therapy
I Najera, A Holguin, ME Quinones-Mateu, MA Muñoz-Fernández, ...
Journal of virology 69 (1), 23-31, 1995
Geographic and temporal trends in the molecular epidemiology and genetic mechanisms of transmitted HIV-1 drug resistance: an individual-patient-and sequence-level meta-analysis
SY Rhee, JL Blanco, MR Jordan, J Taylor, P Lemey, V Varghese, ...
PLoS medicine 12 (4), e1001810, 2015
New observations on antigenic diversification of RNA viruses. Antigenic variation is not dependent on immune selection
E Domingo, J Diez, MA Martinez, J Hernández, A Holguin, B Borrego, ...
Journal of General Virology 74 (10), 2039-2045, 1993
Human immunodeficiency virus type 2 (HIV‐2) in Portugal: Clinical spectrum, circulating subtypes, virus isolation, and plasma viral load
V Soriano, P Gomes, W Heneine, A Holguín, M Doruana, R Antunes, ...
Journal of medical virology 61 (1), 111-116, 2000
Viral quasispecies and the problem of vaccine-escape and drug-resistant mutants
EJ Lien, A Das, P Nandy, S Ren, H Kleinkauf, H von Döhren, ...
Progress in Drug Research/Fortschritte der Arzneimittelforschung/Progrès des …, 1997
Discordances between interpretation algorithms for genotypic resistance to protease and reverse transcriptase inhibitors of human immunodeficiency virus are subtype dependent
J Snoeck, R Kantor, RW Shafer, K Van Laethem, K Deforche, ...
Antimicrobial agents and chemotherapy 50 (2), 694-701, 2006
Emergence of drug resistance mutations in human immunodeficiency virus type 2-infected subjects undergoing antiretroviral therapy
B Rodés, A Holguín, V Soriano, M Dourana, K Mansinho, F Antunes, ...
Journal of Clinical Microbiology 38 (4), 1370-1374, 2000
High prevalence of HIV-1 subtype G and natural polymorphisms at the protease gene among HIV-infected immigrants in Madrid
A Holguín, A Álvarez, V Soriano
Aids 16 (8), 1163-1170, 2002
Increase of non-B subtypes and recombinants among newly diagnosed HIV-1 native Spaniards and immigrants in Spain
A Holguín, M Mulder, G Yebra, M López, V Soriano
Current HIV Research 6 (4), 327-334, 2008
Impact of frequent natural polymorphisms at the protease gene on the in vitro susceptibility to protease inhibitors in HIV-1 non-B subtypes
A Holguı́n, E Paxinos, K Hertogs, C Womac, V Soriano
Journal of clinical virology 31 (3), 215-220, 2004
Prevalence of HIV‐1 non‐B subtypes, syphilis, HTLV, and hepatitis B and C viruses among immigrant sex workers in Madrid, Spain
M Gutiérrez, P Tajada, A Alvarez, R De Julián, M Baquero, V Soriano, ...
Journal of medical virology 74 (4), 521-527, 2004
Evolution of SARS-CoV-2 envelope, membrane, nucleocapsid, and spike structural proteins from the beginning of the pandemic to September 2020: a global and regional approach by …
P Troyano-Hernáez, R Reinosa, Á Holguín
Viruses 13 (2), 243, 2021
Efficacy of antiretroviral therapy in individuals infected with HIV-1 non-B subtypes.
A Holguin, E Ramirez de Arellano, P Rivas, V Soriano
AIDS reviews 8 (2), 98-107, 2006
Natural polymorphisms in the protease gene modulate the replicative capacity of non-B HIV-1 variants in the absence of drug pressure
A Holguín, C Suñe, F Hamy, V Soriano, T Klimkait
Journal of Clinical Virology 36 (4), 264-271, 2006
Performance of three commercial viral load assays, Versant human immunodeficiency virus type 1 (HIV-1) RNA bDNA v3. 0, Cobas AmpliPrep/Cobas TaqMan HIV-1, and NucliSens HIV-1 …
A Holguín, M López, M Molinero, V Soriano
Journal of clinical microbiology 46 (9), 2918-2923, 2008
Drug resistance in the HIV-1-infected paediatric population worldwide: a systematic review
P Rojas Sánchez, A Holguín
Journal of Antimicrobial Chemotherapy 69 (8), 2032-2042, 2014
HIV‐1 subtypes in Spain: a retrospective analysis from 1995 to 2003
E Lospitao, A Alvarez, V Soriano, A Holguin
HIV medicine 6 (5), 313-320, 2005
Natural products and their derivatives as cancer chemopreventive agents
EJ Lien, A Das, P Nandy, S Ren, H Kleinkauf, H von Döhren, ...
Progress in Drug Research/Fortschritte der Arzneimittelforschung/Progrès des …, 1997
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