Follow
Steven G. Younkin
Steven G. Younkin
Professor of Neuroscience, Mayo Clinic
Verified email at mayo.edu
Title
Cited by
Cited by
Year
Correlative memory deficits, Aβ elevation, and amyloid plaques in transgenic mice
K Hsiao, P Chapman, S Nilsen, C Eckman, Y Harigaya, S Younkin, ...
Science 274 (5284), 99-103, 1996
53861996
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease
JC Lambert, CA Ibrahim-Verbaas, D Harold, AC Naj, R Sims, ...
Nature genetics 45 (12), 1452-1458, 2013
43342013
Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to …
D Scheuner, C Eckman, M Jensen, X Song, M Citron, N Suzuki, TD Bird, ...
Nature medicine 2 (8), 864-870, 1996
35571996
Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease
D Harold, R Abraham, P Hollingworth, R Sims, A Gerrish, ML Hamshere, ...
Nature genetics 41 (10), 1088-1093, 2009
32882009
TREM2 Variants in Alzheimer's Disease
R Guerreiro, A Wojtas, J Bras, M Carrasquillo, E Rogaeva, E Majounie, ...
New England Journal of Medicine 368 (2), 117-127, 2013
30572013
An Increased Percentage of Long Amyloid β Protein Secreted by Familial Amyloid β Protein Precursor (βApp717) Mutants
N Suzuki, TT Cheung, XD Cai, A Odaka, L Otvos Jr, C Eckman, TE Golde, ...
Science 264 (5163), 1336-1340, 1994
22201994
Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing
BW Kunkle, B Grenier-Boley, R Sims, JC Bis, V Damotte, AC Naj, ...
Nature genetics 51 (3), 414-430, 2019
21662019
Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease
P Hollingworth, D Harold, R Sims, A Gerrish, JC Lambert, ...
Nature genetics 43 (5), 429-435, 2011
21532011
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease
AC Naj, G Jun, GW Beecham, LS Wang, BN Vardarajan, J Buros, ...
Nature genetics 43 (5), 436-441, 2011
21342011
Familial Alzheimer's disease–linked presenilin 1 variants elevate Aβ1–42/1–40 ratio in vitro and in vivo
DR Borchelt, G Thinakaran, CB Eckman, MK Lee, F Davenport, ...
Neuron 17 (5), 1005-1013, 1996
20871996
Increased amyloid-β42 (43) in brains of mice expressing mutant presenilin 1
K Duff, C Eckman, C Zehr, X Yu, CM Prada, J Perez-Tur, M Hutton, L Buee, ...
Nature 383 (6602), 710-713, 1996
20431996
Production of the Alzheimer amyloid β protein by normal proteolytic processing
M Shoji, TE Golde, J Ghiso, TT Cheung, S Estus, LM Shaffer, XD Cai, ...
Science 258 (5079), 126-129, 1992
19731992
Mutant presenilins specifically elevate the levels of the 42 residue β-amyloid peptide in vivo: evidence for augmentation of a 42-specific γ secretase
JL Jankowsky, DJ Fadale, J Anderson, GM Xu, V Gonzales, NA Jenkins, ...
Human molecular genetics 13 (2), 159-170, 2004
17242004
The'Arctic'APP mutation (E693G) causes Alzheimer's disease by enhanced Aβ protofibril formation
C Nilsberth, A Westlind-Danielsson, CB Eckman, MM Condron, ...
Nature neuroscience 4 (9), 887-893, 2001
15052001
Release of excess amyloid β protein from a mutant amyloid β protein precursor
XD Cai, TE Golde, SG Younkin
Science 259 (5094), 514-516, 1993
14761993
The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease
E Rogaeva, Y Meng, JH Lee, Y Gu, T Kawarai, F Zou, T Katayama, ...
Nature genetics 39 (2), 168-177, 2007
14002007
Age-dependent changes in brain, CSF, and plasma amyloid β protein in the Tg2576 transgenic mouse model of Alzheimer's disease
T Kawarabayashi, LH Younkin, TC Saido, M Shoji, KH Ashe, SG Younkin
Journal of neuroscience 21 (2), 372-381, 2001
12752001
Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice
PF Chapman, GL White, MW Jones, D Cooper-Blacketer, VJ Marshall, ...
Nature neuroscience 2 (3), 271-276, 1999
11761999
Processing of the amyloid protein precursor to potentially amyloidogenic derivatives
TE Golde, S Estus, LH Younkin, DJ Selkoe, SG Younkin
Science 255 (5045), 728-730, 1992
9561992
The relationship between Aβ and memory in the Tg2576 mouse model of Alzheimer's disease
MA Westerman, D Cooper-Blacketer, A Mariash, L Kotilinek, ...
Journal of neuroscience 22 (5), 1858-1867, 2002
9172002
The system can't perform the operation now. Try again later.
Articles 1–20