Human Daxx-mediated repression of human cytomegalovirus gene expression correlates with a repressive chromatin structure around the major immediate early promoter DL Woodhall, IJ Groves, MB Reeves, G Wilkinson, JH Sinclair Journal of Biological Chemistry 281 (49), 37652-37660, 2006 | 210 | 2006 |
Pathogenesis of human papillomavirus‐associated mucosal disease IJ Groves, N Coleman The Journal of pathology 235 (4), 527-538, 2015 | 197 | 2015 |
Extensive co-operation between the Epstein-Barr virus EBNA3 proteins in the manipulation of host gene expression and epigenetic chromatin modification RE White, IJ Groves, E Turro, J Yee, E Kremmer, MJ Allday PloS one 5 (11), e13979, 2010 | 107 | 2010 |
Lytic infection of permissive cells with human cytomegalovirus is regulated by an intrinsic ‘pre-immediate-early’repression of viral gene expression mediated by histone post … IJ Groves, MB Reeves, JH Sinclair Journal of general virology 90 (10), 2364-2374, 2009 | 105 | 2009 |
LIN28 Expression in Malignant Germ Cell Tumors Downregulates let-7 and Increases Oncogene Levels MJ Murray, HK Saini, CA Siegler, JE Hanning, EM Barker, S van Dongen, ... Cancer research 73 (15), 4872-4884, 2013 | 85 | 2013 |
Identification of TRIM23 as a cofactor involved in the regulation of NF-κB by human cytomegalovirus E Poole, I Groves, A Macdonald, Y Pang, A Alcami, J Sinclair Journal of virology 83 (8), 3581-3590, 2009 | 80 | 2009 |
CCCTC-binding factor recruitment to the early region of the human papillomavirus 18 genome regulates viral oncogene expression C Paris, I Pentland, I Groves, DC Roberts, SJ Powis, N Coleman, ... Journal of virology 89 (9), 4770-4785, 2015 | 71 | 2015 |
NF-κB-mediated activation of the chemokine CCL22 by the product of the human cytomegalovirus gene UL144 escapes regulation by viral IE86 E Poole, E Atkins, T Nakayama, O Yoshie, I Groves, A Alcami, J Sinclair Journal of virology 82 (9), 4250-4256, 2008 | 65 | 2008 |
Epstein-Barr virus nuclear antigen EBNA-LP is essential for transforming naive B cells, and facilitates recruitment of transcription factors to the viral genome A Szymula, RD Palermo, A Bayoumy, IJ Groves, M Ba Abdullah, B Holder, ... PLoS pathogens 14 (2), e1006890, 2018 | 60 | 2018 |
Disruption of CTCF-YY1–dependent looping of the human papillomavirus genome activates differentiation-induced viral oncogene transcription I Pentland, K Campos-León, M Cotic, KJ Davies, CD Wood, IJ Groves, ... PLoS biology 16 (10), e2005752, 2018 | 59 | 2018 |
Human papillomavirus genome integration in squamous carcinogenesis: what have next‐generation sequencing studies taught us? IJ Groves, N Coleman The Journal of pathology 245 (1), 9-18, 2018 | 53 | 2018 |
Depletion of HPV16 early genes induces autophagy and senescence in a cervical carcinogenesis model, regardless of viral physical state JE Hanning, HK Saini, MJ Murray, MM Caffarel, S van Dongen, D Ward, ... The Journal of pathology 231 (3), 354-366, 2013 | 46 | 2013 |
Knockdown of hDaxx in normally non-permissive undifferentiated cells does not permit human cytomegalovirus immediate-early gene expression IJ Groves, JH Sinclair Journal of general virology 88 (11), 2935-2940, 2007 | 38 | 2007 |
Virus transcript levels and cell growth rates after naturally occurring HPV16 integration events in basal cervical keratinocytes CG Scarpini, IJ Groves, MR Pett, D Ward, N Coleman The Journal of Pathology 233 (3), 281-293, 2014 | 36 | 2014 |
HPV16 oncogene expression levels during early cervical carcinogenesis are determined by the balance of epigenetic chromatin modifications at the integrated virus genome IJ Groves, ELA Knight, QY Ang, CG Scarpini, N Coleman Oncogene 35 (36), 4773-4786, 2016 | 31 | 2016 |
Bromodomain proteins regulate human cytomegalovirus latency and reactivation allowing epigenetic therapeutic intervention IJ Groves, SE Jackson, EL Poole, A Nachshon, B Rozman, M Schwartz, ... Proceedings of the National Academy of Sciences 118 (9), e2023025118, 2021 | 25 | 2021 |
Short- and long-range cis interactions between integrated HPV genomes and cellular chromatin dysregulate host gene expression in early cervical carcinogenesis IJ Groves, ELA Drane, M Michalski, JM Monahan, CG Scarpini, SP Smith, ... PLoS pathogens 17 (8), e1009875, 2021 | 22 | 2021 |
Targeting the latent human cytomegalovirus reservoir for T-cell-mediated killing with virus-specific nanobodies TWM De Groof, EG Elder, EY Lim, R Heukers, ND Bergkamp, IJ Groves, ... Nature Communications 12 (1), 4436, 2021 | 20 | 2021 |
Human cytomegalovirus major immediate early transcripts arise predominantly from the canonical major immediate early promoter in reactivating progenitor-derived dendritic cells R Mason, IJ Groves, MR Wills, JH Sinclair, MB Reeves Journal of General Virology 101 (6), 635-644, 2020 | 16 | 2020 |
A BMPR2/YY1 signaling axis is required for human cytomegalovirus latency in undifferentiated myeloid cells E Poole, MC Carlan da Silva, C Huang, M Perera, S Jackson, IJ Groves, ... MBio 12 (3), 10.1128/mbio. 00227-21, 2021 | 11 | 2021 |