| Enhanced basal activation of mitogen-activated protein kinases in adipocytes from type 2 diabetes: potential role of p38 in the downregulation of GLUT4 expression CJ Carlson, S Koterski, RJ Sciotti, GB Poccard, CM Rondinone Diabetes 52 (3), 634-641, 2003 | 300 | 2003 |
| Enantioselective total synthesis of (-)-chlorothricolide WR Roush, RJ Sciotti Journal of the American Chemical Society 116 (14), 6457-6458, 1994 | 174 | 1994 |
| Enantioselective total synthesis of (-)-chlorothricolide WR Roush, RJ Sciotti Journal of the American Chemical Society 116 (14), 6457-6458, 1994 | 174 | 1994 |
| A dominant-negative p38 MAPK mutant and novel selective inhibitors of p38 MAPK reduce insulin-stimulated glucose uptake in 3T3-L1 adipocytes without affecting GLUT4 translocation R Somwar, S Koterski, G Sweeney, R Sciotti, S Djuric, C Berg, J Trevillyan, ... Journal of Biological Chemistry 277 (52), 50386-50395, 2002 | 164 | 2002 |
| 3, 5-Bis (trifluoromethyl) pyrazoles: a novel class of NFAT transcription factor regulator SW Djuric, NY BaMaung, A Basha, H Liu, JR Luly, DJ Madar, RJ Sciotti, ... Journal of medicinal chemistry 43 (16), 2975-2981, 2000 | 159 | 2000 |
| Enantioselective total synthesis of (−)-chlorothricolide via the tandem inter-and intramolecular Diels− Alder reaction of a hexaenoate intermediate WR Roush, RJ Sciotti Journal of the American Chemical Society 120 (30), 7411-7419, 1998 | 154 | 1998 |
| CYP450 phenotyping and accurate mass identification of metabolites of the 8-aminoquinoline, anti-malarial drug primaquine BS Pybus, JC Sousa, X Jin, JA Ferguson, RE Christian, R Barnhart, ... Malaria journal 11, 1-9, 2012 | 137 | 2012 |
| Tafenoquine and NPC-1161B require CYP 2D metabolism for anti-malarial activity: implications for the 8-aminoquinoline class of anti-malarial compounds SR Marcsisin, JC Sousa, GA Reichard, D Caridha, Q Zeng, N Roncal, ... Malaria journal 13, 1-9, 2014 | 87 | 2014 |
| Differential CYP 2D6 metabolism alters primaquine pharmacokinetics BMJ Potter, LH Xie, C Vuong, J Zhang, P Zhang, D Duan, TLT Luong, ... Antimicrobial agents and chemotherapy 59 (4), 2380-2387, 2015 | 86 | 2015 |
| 5-(2-Pyrimidinyl)-imidazo [1, 2-a] pyridines are antibacterial agents targeting the ATPase domains of DNA gyrase and topoisomerase IV JT Starr, RJ Sciotti, DL Hanna, MD Huband, LM Mullins, H Cai, JW Gage, ... Bioorganic & medicinal chemistry letters 19 (18), 5302-5306, 2009 | 78 | 2009 |
| Route map for the discovery and pre-clinical development of new drugs and treatments for cutaneous leishmaniasis D Caridha, B Vesely, K van Bocxlaer, B Arana, CE Mowbray, S Rafati, ... International Journal for Parasitology: Drugs and Drug Resistance 11, 106-117, 2019 | 73 | 2019 |
| The synthesis and biological evaluation of a novel series of antimicrobials of the oxazolidinone class RJ Sciotti, M Pliushchev, PE Wiedeman, D Balli, R Flamm, AM Nilius, ... Bioorganic & medicinal chemistry letters 12 (16), 2121-2123, 2002 | 68 | 2002 |
| Discovery and characterization of clinical candidate LXE408 as a kinetoplastid-selective proteasome inhibitor for the treatment of leishmaniases A Nagle, A Biggart, C Be, H Srinivas, A Hein, D Caridha, RJ Sciotti, ... Journal of Medicinal Chemistry 63 (19), 10773-10781, 2020 | 67 | 2020 |
| Protozoan parasite growth inhibitors discovered by cross-screening yield potent scaffolds for lead discovery W Devine, JL Woodring, U Swaminathan, E Amata, G Patel, J Erath, ... Journal of medicinal chemistry 58 (14), 5522-5537, 2015 | 67 | 2015 |
| Novel benzoxaborole, nitroimidazole and aminopyrazoles with activity against experimental cutaneous leishmaniasis K Van Bocxlaer, D Caridha, C Black, B Vesely, S Leed, RJ Sciotti, ... International Journal for Parasitology: Drugs and Drug Resistance 11, 129-138, 2019 | 65 | 2019 |
| Synthesis of N-arylated oxazolidinones via a palladium catalyzed cross coupling reaction. Application to the synthesis of the antibacterial agent Dup-721 DJ Madar, H Kopecka, D Pireh, J Pease, M Pliushchev, RJ Sciotti, ... Tetrahedron Letters 42 (22), 3681-3684, 2001 | 64 | 2001 |
| A Chemotype That Inhibits Three Unrelated Pathogenic Targets: The Botulinum Neurotoxin Serotype A Light Chain, P. falciparum Malaria, and the Ebola Filovirus I Opsenica, JC Burnett, R Gussio, D Opsenica, N Todorovic, CA Lanteri, ... Journal of medicinal chemistry 54 (5), 1157-1169, 2011 | 63 | 2011 |
| Azole inhibitors of cytokine production NY BaMaung, A Basha, SW Djuric, EJ Gubbins, JR Luly, NP Tu, DJ Madar, ... US Patent App. 09/289,155, 2001 | 59 | 2001 |
| Auranofin Is an Apoptosis-Simulating Agent with in Vitro and in Vivo Anti-leishmanial Activity ER Sharlow, S Leimgruber, S Murray, A Lira, RJ Sciotti, M Hickman, ... ACS chemical biology 9 (3), 663-672, 2014 | 58 | 2014 |
| 4-Amino-7-chloroquinolines: probing ligand efficiency provides botulinum neurotoxin serotype A light chain inhibitors with significant antiprotozoal activity IM Opsenica, M Tot, L Gomba, JE Nuss, RJ Sciotti, S Bavari, JC Burnett, ... Journal of medicinal chemistry 56 (14), 5860-5871, 2013 | 58 | 2013 |
