| Analysis of the aphthovirus 2A/2B polyprotein ‘cleavage’mechanism indicates not a proteolytic reaction, but a novel translational effect: a putative ribosomal ‘skip’ MLL Donnelly, G Luke, A Mehrotra, X Li, LE Hughes, D Gani, MD Ryan Journal of General Virology 82 (5), 1013-1025, 2001 | 1032 | 2001 |
| The ‘cleavage’activities of foot-and-mouth disease virus 2A site-directed mutants and naturally occurring ‘2A-like’sequences MLL Donnelly, LE Hughes, G Luke, H Mendoza, E Ten Dam, D Gani, ... Journal of General Virology 82 (5), 1027-1041, 2001 | 733 | 2001 |
| Cleavage of foot-and-mouth disease virus polyprotein is mediated by residues located within a 19 amino acid sequence MD Ryan, AMQ King, GP Thomas Journal of General Virology 72 (11), 2727-2732, 1991 | 641 | 1991 |
| Foot‐and‐mouth disease virus 2A oligopeptide mediated cleavage of an artificial polyprotein. MD Ryan, J Drew The EMBO journal 13 (4), 928-933, 1994 | 542 | 1994 |
| E unum pluribus: multiple proteins from a self-processing polyprotein P De Felipe, GA Luke, LE Hughes, D Gani, C Halpin, MD Ryan Trends in biotechnology 24 (2), 68-75, 2006 | 470 | 2006 |
| Virus-encoded proteinases of the picornavirus super-group MD Ryan, M Flint Journal of General Virology 78 (4), 699-723, 1997 | 347 | 1997 |
| Differentiating infection from vaccination in foot-and-mouth disease using a panel of recombinant, non-structural proteins in ELISA DKJ Mackay, MA Forsyth, PR Davies, A Berlinzani, GJ Belsham, M Flint, ... Vaccine 16 (5), 446-459, 1998 | 277 | 1998 |
| The cleavage activities of aphthovirus and cardiovirus 2A proteins. MLL Donnelly, D Gani, M Flint, S Monaghan, MD Ryan Journal of General Virology 78 (1), 13-21, 1997 | 270 | 1997 |
| Site-specific release of nascent chains from ribosomes at a sense codon VA Doronina, C Wu, P De Felipe, MS Sachs, MD Ryan, JD Brown Molecular and cellular biology 28 (13), 4227-4239, 2008 | 239 | 2008 |
| Co-translational, intraribosomal cleavage of polypeptides by the foot-and-mouth disease virus 2A peptide P de Felipe, LE Hughes, MD Ryan, JD Brown Journal of Biological Chemistry 278 (13), 11441-11448, 2003 | 235 | 2003 |
| Occurrence, function and evolutionary origins of ‘2A-like’sequences in virus genomes GA Luke, P De Felipe, A Lukashev, SE Kallioinen, EA Bruno, MD Ryan Journal of General virology 89 (4), 1036-1042, 2008 | 200 | 2008 |
| Self‐processing 2A‐polyproteins–a system for co‐ordinate expression of multiple proteins in transgenic plants C Halpin, SE Cooke, A Barakate, AE Amrani, MD Ryan The plant journal 17 (4), 453-459, 1999 | 195 | 1999 |
| RNA virus attenuation by codon pair deoptimisation is an artefact of increases in CpG/UpA dinucleotide frequencies F Tulloch, NJ Atkinson, DJ Evans, MD Ryan, P Simmonds elife 3, e04531, 2014 | 192 | 2014 |
| Effects of foot-and-mouth disease virus nonstructural proteins on the structure and function of the early secretory pathway: 2BC but not 3A blocks endoplasmic reticulum-to … K Moffat, G Howell, C Knox, GJ Belsham, P Monaghan, MD Ryan, ... Journal of virology 79 (7), 4382-4395, 2005 | 179 | 2005 |
| A case for “StopGo”: reprogramming translation to augment codon meaning of GGN by promoting unconventional termination (Stop) after addition of glycine and then allowing … JF Atkins, NM Wills, G Loughran, CY Wu, K Parsawar, MD Ryan, ... Rna 13 (6), 803-810, 2007 | 173 | 2007 |
| Specificity of enzyme-substrate interactions in foot-and-mouth disease virus polyprotein processing MD Ryan, GJ Belsham, AMQ King Virology 173 (1), 35-45, 1989 | 169 | 1989 |
| 2A peptides provide distinct solutions to driving stop-carry on translational recoding P Sharma, F Yan, VA Doronina, H Escuin-Ordinas, MD Ryan, JD Brown Nucleic acids research 40 (7), 3143-3151, 2012 | 167 | 2012 |
| Use of the 2A sequence from foot-and-mouth disease virus in the generation of retroviral vectors for gene therapy P de Felipe, V Martin, ML Cortes, M Ryan, M Izquierdo Gene therapy 6 (2), 198-208, 1999 | 161 | 1999 |
| Targeting of proteins derived from self‐processing polyproteins containing multiple signal sequences P De Felipe, MD Ryan Traffic 5 (8), 616-626, 2004 | 152 | 2004 |
| Inhibition of the secretory pathway by foot-and-mouth disease virus 2BC protein is reproduced by coexpression of 2B with 2C, and the site of inhibition is determined by the … K Moffat, C Knox, G Howell, SJ Clark, H Yang, GJ Belsham, M Ryan, ... Journal of virology 81 (3), 1129-1139, 2007 | 137 | 2007 |
