Profesor Titular de la Universidad Complutense de Madrid
Verified email at quim.ucm.es
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Fungal ribotoxins: molecular dissection of a family of natural killers
J Lacadena, E Álvarez-García, N Carreras-Sangrà, E Herrero-Galán, ...
FEMS microbiology reviews 31 (2), 212-237, 2007
Characterization of the Antifungal Protein Secreted by the MouldAspergillus giganteus
J Lacadena, AM del Pozo, M Gasset, B Patino, R Campos-Olivas, ...
Archives of biochemistry and biophysics 324 (2), 273-281, 1995
NMR solution structure of the antifungal protein from Aspergillus giganteus: evidence for cysteine pairing isomerism
R Campos-Olivas, M Bruix, J Santoro, J Lacadena, A Martinez del Pozo, ...
Biochemistry 34 (9), 3009-3021, 1995
The highly refined solution structure of the cytotoxic ribonuclease α-sarcin reveals the structural requirements for substrate recognition and ribonucleolytic activity
JM Pérez-Cañadillas, J Santoro, R Campos-Olivas, J Lacadena, ...
Journal of molecular biology 299 (4), 1061-1073, 2000
Characterization of pKa Values and Titration Shifts in the Cytotoxic Ribonuclease α-Sarcin by NMR. Relationship between Electrostatic Interactions, Structure, and …
JM Pérez-Cañadillas, R Campos-Olivas, J Lacadena, AM del Pozo, ...
Biochemistry 37 (45), 15865-15876, 1998
Overproduction and purification of biologically active native fungal α-sarcin in Escherichia coli
J Lacadena, AM del Pozo, JL Barbero, JM Mancheño, M Gasset, ...
Gene 142 (1), 147-151, 1994
Role of histidine‐50, glutamic acid‐96, and histidine‐137 in the ribonucleolytic mechanism of the ribotoxin α‐sarcin
J Lacadena, Á Martínez del Pozo, A Martínez‐Ruiz, JM Pérez‐Cañadillas, ...
Proteins: Structure, Function, and Bioinformatics 37 (3), 474-484, 1999
RNase U2 and alpha-sarcin: a study of relationships.
A Martínez-Ruiz, L Garcia-Ortega, R Kao, J Lacadena, M Onaderra, ...
Methods in enzymology 341, 335-351, 2000
Translocation of α-sarcin across the lipid bilayer of asolectin vesicles
M Oñaderra, JM Mancheño, M Gasset, J Lacadena, G Schiavo, ...
Biochemical journal 295 (1), 221-225, 1993
Fungal ribotoxins: a review of potential biotechnological applications
M Olombrada, R Lázaro-Gorines, JC López-Rodríguez, ...
Toxins 9 (2), 71, 2017
Anomalous electrophoretic behavior of a very acidic protein: ribonuclease U2
L García‐Ortega, V De los Ríos, A Martínez‐Ruiz, M Oñaderra, ...
Electrophoresis 26 (18), 3407-3413, 2005
Secretion of Recombinant Pro-and Mature Fungal α-Sarcin Ribotoxin by the Methylotrophic YeastPichia pastoris: The Lys–Arg Motif Is Required for Maturation
A Martı́nez-Ruiz, AM del Pozo, J Lacadena, JM Mancheno, M Onaderra, ...
Protein expression and purification 12 (3), 315-322, 1998
The cytotoxin α‐sarcin behaves as a cyclizing ribonuclease
J Lacadena, A Martı́nez del Pozo, V Lacadena, A Martı́nez-Ruiz, ...
FEBS letters 424 (1-2), 46-48, 1998
The insecticidal protein hirsutellin A from the mite fungal pathogen Hirsutella thompsonii is a ribotoxin
E Herrero‐Galán, J Lacadena, A Martinez del Pozo, DG Boucias, N Olmo, ...
Proteins: Structure, Function, and Bioinformatics 72 (1), 217-228, 2008
Structural basis for the catalytic mechanism and substrate specificity of the ribonuclease α‐sarcin
R Campos-Olivas, M Bruix, J Santoro, A Martínez del Pozo, J Lacadena, ...
FEBS letters 399 (1-2), 163-165, 1996
α-Sarcin, a ribosome-inactivating protein that translocates across the membrane of phospholipid vesicles
M Gasset, JM Mancheño, J Lacadena, J Turnay, N Olmo, MA Lizarbe, ...
Curr Top Pept Protein Res 1, 99-104, 1994
Overproduction in Escherichia coli and purification of the hemolytic protein sticholysin II from the sea anemone Stichodactyla helianthus
V de los Rı́os, M Oñaderra, A Martı́nez-Ruiz, J Lacadena, JM Mancheño, ...
Protein expression and purification 18 (1), 71-76, 2000
Characterization of a natural larger form of the antifungal protein (AFP) from Aspergillus giganteus
A Martı́nez-Ruiz, AM del Pozo, J Lacadena, JM Mancheño, M Oñaderra, ...
Biochimica et Biophysica Acta (BBA)-Protein Structure and Molecular …, 1997
Substitution of histidine-137 by glutamine abolishes the catalytic activity of the ribosome-inactivating protein α-sarcin
J Lacadena, JM Mancheño, A Martinez-Ruiz, A Martínez del Pozo, ...
Biochemical journal 309 (2), 581-586, 1995
Membrane interaction of a beta-structure-forming synthetic peptide comprising the 116–139th sequence region of the cytotoxic protein alpha-sarcin
JM Mancheno, M Gasset, JP Albar, J Lacadena, AM del Pozo, ...
Biophysical journal 68 (6), 2387-2395, 1995
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