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Embarek F. Alwedi
Embarek F. Alwedi
Merck, Process Research & Development
Dirección de correo verificada de merck.com
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Development of a Green and Sustainable Manufacturing Process for Gefapixant Citrate (MK-7264) Part 1: Introduction and Process Overview
H Ren, KM Maloney, K Basu, MJ Di Maso, GR Humphrey, F Peng, ...
Organic Process Research & Development 24 (11), 2445-2452, 2020
282020
Manufacturing process development for belzutifan, part 5: a streamlined fluorination–dynamic kinetic resolution process
T Wang, EM Phillips, SM Dalby, E Sirota, S Axnanda, CS Shultz, P Patel, ...
Organic Process Research & Development 26 (3), 543-550, 2021
272021
Chain Extension of Boronic Esters with Lithiooxiranes Generated by Sulfoxide–Metal Exchange–Stereocontrolled Access to 2°/2°, 2°/3°, and 3°/3° Vicinal Diols and Related Compounds
E Alwedi, LN Zakharov, PR Blakemore
European Journal of Organic Chemistry 2014 (30), 6643-6648, 2014
142014
Oxazole Synthesis by Sequential Asmic-Ester Condensations and Sulfanyl–Lithium Exchange–Trapping
LG Mueller Jr, A Chao, E Alwedi, M Natrajan, FF Fleming
Organic Letters 23 (4), 1500-1503, 2021
132021
Asmic: an exceptional building block for isocyanide alkylations
E Alwedi, JA Lujan-Montelongo, BR Pitta, A Chao, R Cortés-Mejía, ...
Organic letters 20 (18), 5910-5913, 2018
132018
Development of a Green and Sustainable Manufacturing Process for Gefapixant Citrate (MK-7264). Part 5: Completion of the API Free Base via a Direct Chlorosulfonylation Process
MJ Di Maso, H Ren, SW Zhang, W Liu, R Desmond, E Alwedi, ...
Organic Process Research & Development 24 (11), 2491-2497, 2020
122020
Asmic Isocyanide‐Nitrile Isomerization‐Alkylations
E Alwedi
Eur.J.Org.Chem 29, 4644-4648, 2019
92019
Isocyanide Purification: C-2 Silica Cleans Up a Dirty Little Secret
FFF Allen Chao, Embarek Alwedi
synthesis 51 (06), 2019
82019
Synthesis and Antibacterial Activity of Certain Fused Azoles and Oxazinones
AM El‐Saghier, EF Alwedi, NM Fawzy
Journal of Heterocyclic Chemistry 49 (3), 664-668, 2012
72012
Engineering Hydroxylase Activity, Selectivity, and Stability for a Scalable Concise Synthesis of a Key Intermediate to Belzutifan
WL Cheung‐Lee, JN Kolev, JA McIntosh, AA Gil, W Pan, L Xiao, ...
Angewandte Chemie International Edition 63 (13), e202316133, 2024
62024
Development of a Green and Sustainable Manufacturing Process for Gefapixant Citrate (MK-7264). Part 6: Development of an Improved Commercial Salt Formation Process
KM Maloney, SW Zhang, AE Mohan, AY Lee, P Larpent, H Ren, ...
Organic Process Research & Development 24 (11), 2498-2504, 2020
62020
Synthesis of the Isocyanide Building Block Asmic, anisylsulfanylmethylisocyanide
E Alwedi, B Altundas, A Chao, ZL Ziminsky, M Natrayan, FF Fleming
Organic Syntheses 98 (98), 147-170, 2021
42021
Evolution of a Green and Sustainable Manufacturing Process for Belzutifan: Part 5─ Chemoenzymatic Diastereoselective Fluorination/DKR
SD McCann, SH Dubina, B Kosjek, E Alwedi, T Behre, SA Burgess, ...
Organic Process Research & Development, 2024
32024
Evolution of a Green and Sustainable Manufacturing Process for Belzutifan: Part 6─ Development of a Nucleophilic Aromatic Substitution in Water
DN Le, TJ Wright, E Alwedi, C Hartmanshenn, H Li, JP McMullen, ...
Organic Process Research & Development, 2024
32024
One-step synthesis of imidazoles from Asmic (anisylsulfanylmethyl isocyanide)
LG Mueller, A Chao, E AlWedi, FF Fleming
Beilstein Journal of Organic Chemistry 17 (1), 1499-1502, 2021
32021
Dearomatization of aromatic asmic isocyanides to complex cyclohexadienes
B Altundas, E Alwedi, Z Song, AR Gogoi, R Dykstra, O Gutierrez, ...
Nature Communications 13 (1), 6444, 2022
22022
Development of a derivatization RP-HPLC method for determination of sulfuryl chloride in chlorosulfonic acid for gefapixant citrate manufacture
C Huang, S Song, W Liu, P Parganiha, P Zhuang, S Lohani, E Alwedi, ...
Journal of Pharmaceutical and Biomedical Analysis 215, 114752, 2022
22022
Exploration of the utility of CF3+ as a reagent for chemical ionisation reaction mass spectrometry
RS Blake, SA Ouheda, EF Alwedi, PS Monks
International Journal of Mass Spectrometry 421, 224-233, 2017
22017
Polar-Radical Cyclization Cascades with Magnesiated Nitriles
S Bolgunas, E Paleo, E Alwedi, Y Wei, TM Keller, FF Fleming
Organic Letters 25 (19), 3512-3516, 2023
2023
Cyclizations With Nitriles and Isocyanides via Cascade Sequences
JM Kornfeind
Drexel University, 2023
2023
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