| Structure of signaling-competent neurotensin receptor 1 obtained by directed evolution in Escherichia coli P Egloff, M Hillenbrand, C Klenk, A Batyuk, P Heine, S Balada, ... Proceedings of the National Academy of Sciences 111 (6), E655-E662, 2014 | 246 | 2014 |
| Modification of nonstructural protein 1 of influenza A virus by SUMO1 K Xu, C Klenk, B Liu, B Keiner, J Cheng, BJ Zheng, L Li, Q Han, C Wang, ... Journal of virology 85 (2), 1086-1098, 2011 | 110 | 2011 |
| High-resolution crystal structure of parathyroid hormone 1 receptor in complex with a peptide agonist J Ehrenmann, J Schöppe, C Klenk, M Rappas, L Kummer, AS Doré, ... Nature structural & molecular biology 25 (12), 1086-1092, 2018 | 102 | 2018 |
| Immunohistochemical identification of the PTHR1 parathyroid hormone receptor in normal and neoplastic human tissues A Lupp, C Klenk, C Röcken, M Evert, C Mawrin, S Schulz European journal of endocrinology 162 (5), 979-986, 2010 | 96 | 2010 |
| Cryo-EM structure of an activated GPCR–G protein complex in lipid nanodiscs M Zhang, M Gui, ZF Wang, C Gorgulla, JJ Yu, H Wu, ZJ Sun, C Klenk, ... Nature structural & molecular biology 28 (3), 258-267, 2021 | 79 | 2021 |
| SUMO-1 controls the protein stability and the biological function of phosducin C Klenk, J Humrich, U Quitterer, MJ Lohse Journal of biological chemistry 281 (13), 8357-8364, 2006 | 78 | 2006 |
| Sumoylation of influenza A virus nucleoprotein is essential for intracellular trafficking and virus growth Q Han, C Chang, L Li, C Klenk, J Cheng, Y Chen, N Xia, Y Shu, Z Chen, ... Journal of virology 88 (16), 9379-9390, 2014 | 76 | 2014 |
| Crystal structures of the human neurokinin 1 receptor in complex with clinically used antagonists J Schöppe, J Ehrenmann, C Klenk, P Rucktooa, M Schütz, AS Doré, ... Nature communications 10 (1), 17, 2019 | 73 | 2019 |
| Directed evolution of G protein-coupled receptors in yeast for higher functional production in eukaryotic expression hosts M Schütz, J Schöppe, E Sedlák, M Hillenbrand, G Nagy-Davidescu, ... Scientific reports 6 (1), 21508, 2016 | 67 | 2016 |
| Regulation of fusion activity by the cytoplasmic domain of a paramyxovirus F protein S Tong, M Li, A Vincent, RW Compans, E Fritsch, R Beier, C Klenk, ... Virology 301 (2), 322-333, 2002 | 60 | 2002 |
| Site-specific, orthogonal labeling of proteins in intact cells with two small biarsenical fluorophores A Zürn, C Klenk, U Zabel, S Reiner, MJ Lohse, C Hoffmann Bioconjugate chemistry 21 (5), 853-859, 2010 | 55 | 2010 |
| Formation of a ternary complex among NHERF1, β-arrestin, and parathyroid hormone receptor C Klenk, T Vetter, A Zürn, JP Vilardaga, PA Friedman, B Wang, MJ Lohse Journal of biological chemistry 285 (39), 30355-30362, 2010 | 39 | 2010 |
| Complexes of the neurotensin receptor 1 with small-molecule ligands reveal structural determinants of full, partial, and inverse agonism M Deluigi, A Klipp, C Klenk, L Merklinger, SA Eberle, L Morstein, P Heine, ... Science Advances 7 (5), eabe5504, 2021 | 31 | 2021 |
| A generic selection system for improved expression and thermostability of G protein-coupled receptors by directed evolution C Klenk, J Ehrenmann, M Schütz, A Plückthun Scientific reports 6 (1), 21294, 2016 | 28 | 2016 |
| Generation of fluorogen-activating designed ankyrin repeat proteins (FADAs) as versatile sensor tools M Schütz, A Batyuk, C Klenk, L Kummer, S De Picciotto, B Gülbakan, ... Journal of molecular biology 428 (6), 1272-1289, 2016 | 26 | 2016 |
| G proteins in reverse mode: receptor-mediated GTP release inhibits G protein and effector function LG Hommers, C Klenk, C Dees, M Bünemann Journal of biological chemistry 285 (11), 8227-8233, 2010 | 24 | 2010 |
| Agonist-regulated cleavage of the extracellular domain of parathyroid hormone receptor type 1 C Klenk, S Schulz, D Calebiro, MJ Lohse Journal of biological chemistry 285 (12), 8665-8674, 2010 | 20 | 2010 |
| Crystal structure of the α1B-adrenergic receptor reveals molecular determinants of selective ligand recognition M Deluigi, L Morstein, M Schuster, C Klenk, L Merklinger, RR Cridge, ... Nature communications 13 (1), 382, 2022 | 17 | 2022 |
| Blocking them all: β-arrestins inhibit cellular signaling MJ Lohse, C Klenk Molecular cell 31 (5), 619-621, 2008 | 10 | 2008 |
| Engineering of challenging G protein-coupled receptors for structure determination and biophysical studies Y Waltenspühl, J Ehrenmann, C Klenk, A Plückthun Molecules 26 (5), 1465, 2021 | 6 | 2021 |
Andreas PluckthunBiochemisches Institut, Universität ZürichVerified email at bioc.uzh.ch
