Klaus Okkenhaug
Klaus Okkenhaug
Professor of Immunology, Department of Pathology, University of Cambridge
Verified email at - Homepage
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Requirement of bic/microRNA-155 for normal immune function
A Rodriguez, E Vigorito, S Clare, MV Warren, P Couttet, DR Soond, ...
Science 316 (5824), 608, 2007
Cellular function of phosphoinositide 3-kinases: implications for development, immunity, homeostasis, and cancer
R Katso, K Okkenhaug, K Ahmadi, S White, J Timms, MD Waterfield
Annual review of cell and developmental biology 17 (1), 615-675, 2001
Ribosomal protein S6 kinase 1 signaling regulates mammalian life span
C Selman, J Tullet, D Wieser, E Irvine, SJ Lingard, AI Choudhury, M Claret, ...
Science 326 (5949), 140, 2009
Impaired B and T cell antigen receptor signaling in p110delta PI 3-kinase mutant mice
K Okkenhaug, A Bilancio, G Farjot, H Priddle, S Sancho, E Peskett, ...
Science 297 (5583), 1031, 2002
PI3K in lymphocyte development, differentiation and activation
K Okkenhaug, B Vanhaesebroeck
Nature Reviews Immunology 3 (4), 317-330, 2003
Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice
C Selman, S Lingard, AI Choudhury, RL Batterham, M Claret, M Clements, ...
The FASEB Journal 22 (3), 807-818, 2008
Critical role for the p110α phosphoinositide-3-OH kinase in growth and metabolic regulation
LC Foukas, M Claret, W Pearce, K Okkenhaug, S Meek, E Peskett, ...
Nature 441 (7091), 366-370, 2006
Phosphoinositide 3-Kinase δ Gene Mutation Predisposes to Respiratory Infection and Airway Damage
I Angulo, O Vadas, F Garšon, E Banham-Hall, V Plagnol, TR Leahy, ...
PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8+ T cells
DK Finlay, E Rosenzweig, LV Sinclair, C Feijoo-Carnero, JL Hukelmann, ...
The Journal of Experimental Medicine 209 (13), 2441-2453, 2012
Essential role for the p110δ phosphoinositide 3-kinase in the allergic response
K Ali, A Bilancio, M Thomas, W Pearce, AM Gilfillan, C Tkaczyk, N Kuehn, ...
Nature 431 (7011), 1007-1011, 2004
Inactivation of PI(3)K p110δ breaks regulatory T-cell-mediated immune tolerance to cancer
K Ali, DR Soond, R Pi˝eiro, T Hagemann, W Pearce, EL Lim, H Bouabe, ...
Nature 510 (7505), 407-411, 2014
Cutting edge: the Foxp3 target miR-155 contributes to the development of regulatory T cells
S Kohlhaas, OA Garden, C Scudamore, M Turner, K Okkenhaug, ...
The Journal of Immunology 182 (5), 2578-2582, 2009
Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking
LV Sinclair, D Finlay, C Feijoo, GH Cornish, A Gray, A Ager, K Okkenhaug, ...
Nature immunology 9 (5), 513-521, 2008
The p110β isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110γ
J Guillermet-Guibert, K Bjorklof, A Salpekar, C Gonella, F Ramadani, ...
Proceedings of the National Academy of Sciences 105 (24), 8292-8297, 2008
Ionic immune suppression within the tumour microenvironment limits T cell effector function
R Eil, SK Vodnala, D Clever, CA Klebanoff, M Sukumar, JH Pan, ...
Nature 537 (7621), 539-543, 2016
Signaling by the Phosphoinositide 3-Kinase Family in Immune Cells
K Okkenhaug
Annual review of immunology 31 (1), 2013
Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils
AM Condliffe, K Davidson, KE Anderson, CD Ellson, T Crabbe, ...
Blood 106 (4), 1432-1440, 2005
Clinical spectrum and features of activated phosphoinositide 3-kinase δ syndrome: a large patient cohort study
TI Coulter, A Chandra, CM Bacon, J Babar, J Curtis, N Screaton, ...
Journal of Allergy and Clinical Immunology 139 (2), 597-606. e4, 2017
Cutting edge: the phosphoinositide 3-kinase p110δ is critical for the function of CD4+ CD25+ Foxp3+ regulatory T cells
DT Patton, OA Garden, WP Pearce, LE Clough, CR Monk, E Leung, ...
The Journal of Immunology 177 (10), 6598-6602, 2006
Cutting edge: differential roles for phosphoinositide 3-kinases, p110γ and p110δ, in lymphocyte chemotaxis and homing
K Reif, K Okkenhaug, T Sasaki, JM Penninger, B Vanhaesebroeck, ...
The Journal of Immunology 173 (4), 2236-2240, 2004
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