Adrian Velazquez-Campoy
Adrian Velazquez-Campoy
ARAID Research Scientist - Institute BIFI - University of Zaragoza
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Isothermal titration calorimetry to determine association constants for high-affinity ligands
A Velazquez-Campoy, E Freire
Nature Protocols 1 (1), 186, 2006
2482006
ITC in the post-genomic era…? Priceless
AV Campoy, E Freire
Biophysical Chemistry 115 (2), 115-124, 2005
2282005
Characterization of protein-protein interactions by isothermal titration calorimetry
A Velazquez-Campoy, SA Leavitt, E Freire
Methods in Molecular Biology 261, 35-54, 2004
2112004
Isothermal titration calorimetry
A Velázquez‐Campoy, H Ohtaka, A Nezami, S Muzammil, E Freire
Current Protocols in Cell Biology, 17.8.1-17.8.24, 2004
2002004
The binding energetics of first-and second-generation HIV-1 protease inhibitors: implications for drug design
A Velazquez-Campoy, Y Kiso, E Freire
Archives of biochemistry and biophysics 390 (2), 169-175, 2001
1842001
Catalytic efficiency and vitality of HIV-1 proteases from African viral subtypes
A Velazquez-Campoy, MJ Todd, S Vega, E Freire
Proceedings of the National Academy of Sciences 98 (11), 6062-6067, 2001
1682001
Identification of novel inhibitors of the SARS coronavirus main protease 3CLpro
U Bacha, J Barrila, A Velazquez-Campoy, SA Leavitt, E Freire
Biochemistry 43 (17), 4906-4912, 2004
1612004
Identification of pharmacological chaperones as potential therapeutic agents to treat phenylketonuria
AL Pey, M Ying, N Cremades, A Velazquez-Campoy, T Scherer, B Thöny, ...
The Journal of Clinical Investigation 118 (8), 2858, 2008
1532008
HIV-1 protease inhibitors: enthalpic versus entropic optimization of the binding affinity
A Velazquez-Campoy, MJ Todd, E Freire
Biochemistry 39 (9), 2201-2207, 2000
1462000
Overcoming drug resistance in HIV‐1 chemotherapy: the binding thermodynamics of Amprenavir and TMC‐126 to wild‐type and drug‐resistant mutants of the HIV‐1 protease
H Ohtaka, A Velázquez‐Campoy, D Xie, E Freire
Protein Science 11 (8), 1908-1916, 2002
1402002
Thermodynamic basis of resistance to HIV-1 protease inhibition: calorimetric analysis of the V82F/I84V active site resistant mutant
MJ Todd, I Luque, A Velázquez-Campoy, E Freire
Biochemistry 39 (39), 11876-11883, 2000
1362000
Isothermal titration calorimetry: general formalism using binding polynomials
E Freire, A Schön, A Velazquez‐Campoy
Methods in Enzymology 455, 127-155, 2009
1262009
Amplification of the effects of drug resistance mutations by background polymorphisms in HIV-1 protease from African subtypes
A Velazquez-Campoy, S Vega, E Freire
Biochemistry 41 (27), 8613-8619, 2002
1132002
Thermodynamic dissection of the binding energetics of KNI‐272, a potent HIV‐1 protease inhibitor
A Velazquez‐Campoy, I Luque, MJ Todd, M Milutinovich, Y Kiso, E Freire
Protein Science 9 (9), 1801-1809, 2000
1052000
Evolutionarily conserved proteins MnmE and GidA catalyze the formation of two methyluridine derivatives at tRNA wobble positions
I Moukadiri, S Prado, J Piera, A Velázquez-Campoy, GR Björk, ...
Nucleic Acids Research 37 (21), 7177-7193, 2009
862009
Thermodynamic rules for the design of high affinity HIV-1 protease inhibitors with adaptability to mutations and high selectivity towards unwanted targets
H Ohtaka, S Muzammil, A Schön, A Velazquez-Campoy, S Vega, E Freire
The International Journal of Biochemistry & Cell Biology 36 (9), 1787-1799, 2004
862004
Repositioning tolcapone as a potent inhibitor of transthyretin amyloidogenesis and associated cellular toxicity
R Sant'Anna, P Gallego, LZ Robinson, A Pereira-Henriques, N Ferreira, ...
Nature Communications 7, 10787, 2016
792016
Structural and thermodynamic basis of resistance to HIV-1 protease inhibition: implications for inhibitor design
A Velazquez-Campoy, S Muzammil, H Ohtaka, A Schon, S Vega, E Freire
Current Drug Targets - Infectious Disorders 3 (4), 311-328, 2003
702003
A structural and thermodynamic escape mechanism from a drug resistant mutation of the HIV‐1 protease
S Vega, LW Kang, A Velazquez‐Campoy, Y Kiso, LM Amzel, E Freire
Proteins: Structure, Function, and Bioinformatics 55 (3), 594-602, 2004
672004
Identification of a Drug Targeting an Intrinsically Disordered Protein Involved in Pancreatic Adenocarcinoma
JL Neira, J Bintz, M Arruebo, B Rizzuti, T Bonacci, S Vega, A Lanas, ...
Scientific Reports 7, 39732, 2017
562017
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