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Madhukumar Venkatesh
Madhukumar Venkatesh
Verified email at aecom.yu.edu
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Cited by
Year
Alleviating cancer drug toxicity by inhibiting a bacterial enzyme
BD Wallace, H Wang, KT Lane, JE Scott, J Orans, JS Koo, M Venkatesh, ...
Science 330 (6005), 831-835, 2010
9922010
Symbiotic bacterial metabolites regulate gastrointestinal barrier function via the xenobiotic sensor PXR and Toll-like receptor 4
M Venkatesh, S Mukherjee, H Wang, H Li, K Sun, AP Benechet, Z Qiu, ...
Immunity 41 (2), 296-310, 2014
8272014
Structure and inhibition of microbiome β-glucuronidases essential to the alleviation of cancer drug toxicity
BD Wallace, AB Roberts, RM Pollet, JD Ingle, KA Biernat, SJ Pellock, ...
Chemistry & biology 22 (9), 1238-1249, 2015
2492015
The phytoestrogen coumestrol is a naturally occurring antagonist of the human pregnane X receptor
H Wang, H Li, LB Moore, MDL Johnson, JM Maglich, B Goodwin, ...
Molecular endocrinology 22 (4), 838-857, 2008
1482008
Molecular insights into microbial β-glucuronidase inhibition to abrogate CPT-11 toxicity
AB Roberts, BD Wallace, MK Venkatesh, S Mani, MR Redinbo
Molecular Pharmacology 84 (2), 208-217, 2013
1432013
Pregnane X receptor activation induces FGF19-dependent tumor aggressiveness in humans and mice
H Wang, M Venkatesh, H Li, R Goetz, S Mukherjee, A Biswas, L Zhu, ...
The Journal of clinical investigation 121 (8), 3220-3232, 2011
1422011
Expanding the roles for pregnane X receptor in cancer: proliferation and drug resistance in ovarian cancer
D Gupta, M Venkatesh, H Wang, S Kim, M Sinz, GL Goldberg, K Whitney, ...
Clinical Cancer Research 14 (17), 5332-5340, 2008
1282008
Alleviation of gut inflammation by Cdx2/Pxr pathway in a mouse model of chemical colitis
W Dou, S Mukherjee, H Li, M Venkatesh, H Wang, S Kortagere, A Peleg, ...
PloS one 7 (7), e36075, 2012
952012
In vivo and in vitro characterization of a first-in-class novel azole analog that targets pregnane X receptor activation
M Venkatesh, H Wang, J Cayer, M Leroux, D Salvail, B Das, JE Wrobel, ...
Molecular pharmacology 80 (1), 124-135, 2011
602011
Design, synthesis and biological evaluation of 2H-benzo [b][1, 4] oxazine derivatives as hypoxia targeted compounds for cancer therapeutics
BC Das, AV Madhukumar, J Anguiano, S Mani
Bioorganic & medicinal chemistry letters 19 (15), 4204-4206, 2009
522009
Evaluation of computational docking to identify pregnane X receptor agonists in the ToxCast database
S Kortagere, MD Krasowski, EJ Reschly, M Venkatesh, S Mani, S Ekins
Environmental health perspectives 118 (10), 1412-1417, 2010
452010
Pregnane X receptor regulates pathogen-induced inflammation and host defense against an intracellular bacterial infection through toll-like receptor 4
Z Qiu, JL Cervantes, BB Cicek, S Mukherjee, M Venkatesh, LA Maher, ...
Scientific reports 6 (1), 31936, 2016
432016
Synthesis of novel ketoconazole derivatives as inhibitors of the human pregnane X receptor (PXR; NR1I2; also termed SXR, PAR)
BC Das, AV Madhukumar, J Anguiano, S Kim, M Sinz, TA Zvyaga, ...
Bioorganic & medicinal chemistry letters 18 (14), 3974-3977, 2008
362008
Novel Yeast-Based Strategy Unveils Antagonist Binding Regions on the Nuclear Xenobiotic Receptor PXR
H Li, MR Redinbo, M Venkatesh, S Ekins, A Chaudhry, N Bloch, ...
Journal of Biological Chemistry, 2013
322013
Novel non-enzymatic toxic peptide of Daboia russelii (Eastern region) venom renders commercial polyvalent antivenom ineffective
AV Kumar, TV Gowda
Toxicon 47 (4), 398-408, 2006
212006
Purification, Characterization, and Chemical Modification of Neurotoxic Peptide from Daboia russelii Snake Venom of India
M Venkatesh, N Prasad, T Sing, V Gowda
Journal of Biochemical and Molecular Toxicology 27 (6), 295-304, 2013
172013
Synergistically acting PLA2: Peptide hemorrhagic complex from Daboia russelii venom
M Venkatesh, V Gowda
Toxicon 73, 111-120, 2013
162013
Development and characterization of a genetic mouse model of KRAS mutated colorectal cancer
R Maitra, T Thavornwatanayong, MK Venkatesh, C Chandy, D Vachss, ...
International journal of molecular sciences 20 (22), 5677, 2019
82019
Reovirus oncolysis-Role of cyclin-dependent kinase inhibitor 1
R Maitra, T Augustine, MK Venkatesh, S Goel
Cancer Cell Microenviron 2, e750, 2015
12015
Development of a mouse model of KRAS mutated colorectal cancer tumorigenesis
R Maitra, MK Venkatesh, TA Augustine, C Chandy, Q Liu, S Goel
Cancer Research 77 (13_Supplement), 2799-2799, 2017
2017
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