| Deletion of C9ORF72 results in motor neuron degeneration and stress sensitivity in C. elegans M Therrien, GA Rouleau, PA Dion, JA Parker PloS one 8 (12), e83450, 2013 | 230 | 2013 |
| Cell type-specific transcriptomics reveals that mutant huntingtin leads to mitochondrial RNA release and neuronal innate immune activation H Lee, RJ Fenster, SS Pineda, WS Gibbs, S Mohammadi, ... Neuron 107 (5), 891-908. e8, 2020 | 154 | 2020 |
| Methylene Blue Protects against TDP-43 and FUS Neuronal Toxicity in C. elegans and D. rerio A Vaccaro, SA Patten, S Ciura, C Maios, M Therrien, P Drapeau, ... Public Library of Science 7 (7), e42117, 2012 | 112 | 2012 |
| ALS: recent developments from genetics studies M Therrien, PA Dion, GA Rouleau Current neurology and neuroscience reports 16, 1-12, 2016 | 85 | 2016 |
| Genome-wide in vivo CNS screening identifies genes that modify CNS neuronal survival and mHTT toxicity MH Wertz, MR Mitchem, SS Pineda, LJ Hachigian, H Lee, V Lau, ... Neuron 106 (1), 76-89. e8, 2020 | 71 | 2020 |
| Worming forward: amyotrophic lateral sclerosis toxicity mechanisms and genetic interactions in Caenorhabditis elegans M Therrien, JA Parker Frontiers in genetics 5, 86838, 2014 | 67 | 2014 |
| Expanded ATXN3 frameshifting events are toxic in Drosophila and mammalian neuron models SJ Stochmanski, M Therrien, J Laganiere, D Rochefort, S Laurent, ... Human molecular genetics 21 (10), 2211-2218, 2012 | 48 | 2012 |
| Maple Syrup Decreases TDP-43 Proteotoxicity in a Caenorhabditis elegans Model of Amyotrophic Lateral Sclerosis (ALS) C Aaron, G Beaudry, JA Parker, M Therrien Journal of agricultural and food chemistry 64 (17), 3338-3344, 2016 | 27 | 2016 |
| Exposure of iPSC-derived human microglia to brain substrates enables the generation and manipulation of diverse transcriptional states in vitro MJ Dolan, M Therrien, S Jereb, T Kamath, V Gazestani, T Atkeson, ... Nature Immunology 24 (8), 1382-1390, 2023 | 21 | 2023 |
| Early Alzheimer’s disease pathology in human cortex involves transient cell states V Gazestani, T Kamath, NM Nadaf, A Dougalis, SJ Burris, B Rooney, ... Cell 186 (20), 4438-4453. e23, 2023 | 19 | 2023 |
| FET proteins regulate lifespan and neuronal integrity M Therrien, GA Rouleau, PA Dion, JA Parker Scientific reports 6 (1), 25159, 2016 | 17 | 2016 |
| Exome sequencing of sporadic childhood‐onset schizophrenia suggests the contribution of X‐linked genes in males A Ambalavanan, B Chaumette, S Zhou, P Xie, Q He, D Spiegelman, ... American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 180 …, 2019 | 16 | 2019 |
| A resource for generating and manipulating human microglial states in vitro MJ Dolan, M Therrien, S Jereb, T Kamath, T Atkeson, SE Marsh, A Goeva, ... BioRxiv, 2022.05. 02.490100, 2022 | 12 | 2022 |
| Single-nucleus sequencing reveals enriched expression of genetic risk factors sensitises Motor Neurons to degeneration in ALS F Limone, D Mordes, A Couto, O Pietiläinen, BJ Joseph, A Burberry, ... BioRxiv, 1-9, 2021 | 12 | 2021 |
| Redefining microglia states: Lessons and limits of human and mouse models to study microglia states in neurodegenerative diseases TY de Soysa, M Therrien, AC Walker, B Stevens Seminars in Immunology 60, 101651, 2022 | 9 | 2022 |
| Deciphering genetic interactions between ALS genes using C. elegans M Therrien, JA Parker Worm 3 (2), e29047, 2014 | 6 | 2014 |
| FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity N Wieder, JC Fried, C Kim, EH Sidhom, MR Brown, JL Marshall, ... Cell metabolism 35 (5), 887-905. e11, 2023 | 5 | 2023 |
| Early Alzheimer’s disease pathology in human cortex is associated with a transient phase of distinct cell states V Gazestani, T Kamath, NM Nadaf, SJ Burris, B Rooney, A Junkkari, ... bioRxiv, 2023 | 3 | 2023 |
| Single-nucleus sequencing reveals enriched expression of genetic risk factors in Extratelencephalic Neurons sensitive to degeneration in ALS F Limone, DA Mordes, A Couto, BJ Joseph, JM Mitchell, M Therrien, ... bioRxiv, 2021.07. 12.452054, 2021 | 2 | 2021 |
| Resolving CNS mRNA Heterogeneity: Examining mRNA Alternative Polyadenylation at a Cell-Type-Specific Level M Therrien, M Heiman Neuron 95 (6), 1232-1233, 2017 | 1 | 2017 |
