| Targeting C-reactive protein for the treatment of cardiovascular disease MB Pepys, GM Hirschfield, GA Tennent, J Ruth Gallimore, MC Kahan, ... Nature 440 (7088), 1217-1221, 2006 | 895 | 2006 |
| β-Secretase (BACE1) inhibitors with high in vivo efficacy suitable for clinical evaluation in Alzheimer’s disease H Hilpert, W Guba, TJ Woltering, W Wostl, E Pinard, H Mauser, ... Journal of medicinal chemistry 56 (10), 3980-3995, 2013 | 154 | 2013 |
| The Total Synthesis of (±)-11-O-Debenzoyltashironin SP Cook, A Polara, SJ Danishefsky Journal of the American Chemical Society 128 (51), 16440-16441, 2006 | 103 | 2006 |
| A fascination with 1, 2-diacetals SV Ley, A Polara The Journal of Organic Chemistry 72 (16), 5943-5959, 2007 | 69 | 2007 |
| Highly Diastereoselective Lithium Enolate Aldol Reactions of Butane-2,3-diacetal Desymmetrized Glycolic Acid and Deprotection to Enantiopure anti-2,3-Dihydroxy … DJ Dixon, SV Ley, A Polara, T Sheppard Organic letters 3 (23), 3749-3752, 2001 | 60 | 2001 |
| Studies on the generation of enolate anions from butane-2, 3-diacetal protected glycolic acid derivatives and subsequent highly diastereoselective coupling reactions with … SV Ley, DJ Dixon, RT Guy, MA Palomero, A Polara, F Rodríguez, ... Organic & biomolecular chemistry 2 (24), 3618-3627, 2004 | 47 | 2004 |
| The use of butane diacetals of glycolic acid as precursors for the synthesis of the phytotoxic calmodulin inhibitor herbarumin II E Díez, DJ Dixon, SV Ley, A Polara, F Rodríguez Helvetica chimica acta 86 (11), 3717-3729, 2003 | 38 | 2003 |
| Multiple chirality transfers in the enantioselective synthesis of 11-O-debenzoyltashironin. Chiroptical analysis of the key cascade A Polara, SP Cook, SJ Danishefsky Tetrahedron letters 49 (41), 5906-5908, 2008 | 29 | 2008 |
| 1, 3-oxazines as BACE 1 and/or BACE2 inhibitors H Hilpert, R Narquizian, E Pinard, A Polara, M Rogers-Evans, T Woltering, ... US Patent 8,785,436, 2014 | 24 | 2014 |
| Total synthesis of the phytotoxic agent herbarumin II using butane diacetals of glycolic acid as building blocks E Diez, DJ Dixon, SV Ley, A Polara, F Rodriguez Synlett 2003 (08), 1186-1188, 2003 | 16 | 2003 |
| Synthesis of spongistatin 2 employing a new route to the EF fragment H Kraus, A Français, M O'Brien, J Frost, A Diéguez-Vázquez, A Polara, ... Chemical Science 4 (5), 1989-1994, 2013 | 6 | 2013 |
| Highly diastereoselective ketone aldol reactions of butane-2, 3-diacetal desymmetrised glycolic acid DJ Dixon, A Guarna, SV Ley, A Polara, F Rodriguez Synthesis 2002 (14 Special Issue), 1973-1978, 2002 | 4 | 2002 |
| [1, 3] oxazines E Boroni, L Gobbi, H Hilpert, M Honer, D Murl, R Narquizian, A Polara US Patent 9,073,909, 2015 | 1 | 2015 |
| Dihydrooxazol-2-amine derivatives M Nettekoven, R Norcross, A Polara US Patent 8,673,950, 2014 | 1 | 2014 |
| Dihydrooxazol-2-amine derivatives M Nettekoven, R Norcross, A Polara US Patent App. 14/014,619, 2013 | 1 | 2013 |
| Oxazoline derivatives G Galley, R Norcross, A Polara US Patent 8,354,441, 2013 | 1 | 2013 |
| RO6807936 as a novel positron emission tomography (PET) radiotracer for in vitro and in vivo visualization and quantification of beta‐site amyloid precursor protein cleaving … M Honer, A Polara, H Kuwabara, H Jacobsen, A Pähler, T Hartung, ... Journal of Labelled Compounds and Radiopharmaceuticals 66 (9), 222-236, 2023 | | 2023 |
| RO6807936 as a Novel PET Radiotracer for in Vitro and in Vivo Visualization and Quantification of BACE1 in the Rodent and Baboon Brain. M Honer, A Polara, H Kuwabara, H Jacobsen, A Pähler, T Hartung, ... Journal of Labelled Compounds & Radiopharmaceuticals, 2023 | | 2023 |
| Radiosynthesis and characterization of RO6807936, a novel tracer for the visualization of BACE1 in the rodent and baboon brain L Gobbi, M Honer, H Hilpert, A Polara, D Muri, J Helmut, DP Holt, ... JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS 56, S299-S299, 2013 | | 2013 |
| P1‐138: Distribution of BACE1 in the rodent, monkey and human brain L Gobbi, M Honer, A Polara, H Jacobsen, T Hartung, D Muri, D Esterhazy, ... Alzheimer's & Dementia 8 (4S_Part_4), P154-P154, 2012 | | 2012 |
Darren J. DixonProfessor of Chemistry, University of OxfordVerified email at cortexorganics.com
