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Simone Perazzolo
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The influence of placental metabolism on fatty acid transfer to the fetus
S Perazzolo, B Hirschmugl, C Wadsack, G Desoye, RM Lewis, ...
Journal of lipid research 58 (2), 443-454, 2017
1122017
Three HIV drugs, atazanavir, ritonavir, and tenofovir, coformulated in drug-combination nanoparticles exhibit long-acting and lymphocyte-targeting properties in nonhuman primates
S Perazzolo, LM Shireman, J Koehn, LA McConnachie, JC Kraft, ...
Journal of pharmaceutical sciences 107 (12), 3153-3162, 2018
432018
Modelling the effect of intervillous flow on solute transfer based on 3D imaging of the human placental microstructure
S Perazzolo, RM Lewis, BG Sengers
Placenta 60, 21-27, 2017
272017
Phenylalanine transfer across the isolated perfused human placenta: an experimental and modeling investigation
EM Lofthouse, S Perazzolo, S Brooks, IP Crocker, JD Glazier, ...
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE …, 2016
242016
In vivo kinetic study of materno‐fetal fatty acid transfer in obese and normal weight pregnant women
A Gázquez, MT Prieto‐Sánchez, JE Blanco‐Carnero, D van Harskamp, ...
The Journal of physiology 597 (19), 4959-4973, 2019
192019
Systems and clinical pharmacology of COVID-19 therapeutic candidates: a clinical and translational medicine perspective
S Perazzolo, L Zhu, W Lin, A Nguyen, RJY Ho
Journal of Pharmaceutical Sciences 110 (3), 1002-1017, 2021
182021
Integration of computational and experimental approaches to elucidate mechanisms of first-pass lymphatic drug sequestration and long-acting pharmacokinetics of the injectable …
S Perazzolo, LM Shireman, LA McConnachie, J Koehn, L Kinman, W Lee, ...
Journal of pharmaceutical sciences 109 (5), 1789-1801, 2020
182020
Placental mobilization of free fatty acids contributes to altered materno-fetal transfer in obesity
B Hirschmugl, S Perazzolo, BG Sengers, RM Lewis, M Gruber, G Desoye, ...
International Journal of Obesity 45 (5), 1114-1123, 2021
132021
Computational modelling of fatty acid transport in the human placenta
S Perazzolo, B Hirschmugl, C Wadsack, G Desoye, RM Lewis, ...
IEEE Engineering in Medicine and Biology Society (EMBC), 2015 37th Annual …, 2015
112015
Novel long-acting drug combination nanoparticles composed of gemcitabine and paclitaxel enhance localization of both drugs in metastatic breast cancer nodules
J Yu, Q Mu, S Perazzolo, JI Griffin, L Zhu, LA McConnachie, DD Shen, ...
Pharmaceutical research 37, 1-18, 2020
102020
Physiologically based pharmacokinetic modeling of 3 HIV drugs in combination and the role of lymphatic system after subcutaneous dosing. Part 2: Model for the drug-combination …
S Perazzolo, DD Shen, RJY Ho
Journal of pharmaceutical sciences 111 (3), 825-837, 2022
92022
Physiologically based pharmacokinetic modeling of 3 HIV drugs in combination and the role of lymphatic system after subcutaneous dosing. Part 1: model for the free-drug mixture
S Perazzolo, LM Shireman, DD Shen, RJY Ho
Journal of pharmaceutical sciences 111 (2), 529-541, 2022
72022
Bictegravir plus tenofovir alafenamide nanoformulation as a long-acting pre-exposure prophylaxis regimen: application of modeling to design non-human primate pharmacokinetic …
S Perazzolo, S Mandal, PK Prathipati, CJ Destache
Frontiers in Pharmacology 11, 603242, 2020
62020
Modelling nutrient transfer based on 3D imaging of the human placental microstructure
S Perazzolo, RM Lewis, BG Sengers
IEEE Engineering in Medicine and Biology Society (EMBC), 2016 38th Annual …, 2016
22016
Physiologically based Pharmacokinetic Model Validated to Enable Predictions of Multiple Drugs in a Long-acting Drug-combination Nano-Particles (DcNP): Confirmation with 3 HIV …
S Perazzolo, DD Shen, AM Scott, RJY Ho
Journal of Pharmaceutical Sciences, 2024
12024
A novel formulation enabled transformation of 3-HIV drugs tenofovir–lamivudine–dolutegravir from short-acting to long-acting all-in-one injectable
S Perazzolo, ZR Stephen, M Eguchi, X Xu, R Delle Fratte, AC Collier, ...
AIDS 37 (14), 2131-2136, 2023
12023
Viral dissemination and immune activation modulate antiretroviral drug levels in lymph nodes of SIV-infected rhesus macaques
S Srinivasula, P Degrange, S Perazzolo, A Bonvillain, A Tobery, J Kaplan, ...
Frontiers in Immunology 14, 1213455, 2023
12023
Using disposition index to detect early impairment of beta cell function. 19th IDS Congress
M Martino, A Carr, S Perazzolo, A Galderisi, L Marcovecchio, C Dayan
Immunology of Diabetes Society (IDS), Paris, 23–26 May [Poster presentation], 2023
1*2023
Modelling nutrient transfer across the placenta
S Perazzolo
University of Southampton, 2017
12017
Pediatric PBPK Scaling Model for a New Long-Acting, 3 HIV Drug Combination in a Single Injection
S Perazzolo, Z Stephens, R Delle Fratte, BI Rachel A, C Johnson, ...
Conference on Retroviruses and Opportunistic Infections (CROI), 2024
2024
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