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Ayala Tovy
Ayala Tovy
Verified email at bcm.edu
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Year
PPM1D mutations drive clonal hematopoiesis in response to cytotoxic chemotherapy
JI Hsu, T Dayaram, A Tovy, E De Braekeleer, M Jeong, F Wang, J Zhang, ...
Cell stem cell 23 (5), 700-713. e6, 2018
3152018
A New Nuclear Function of the Entamoeba histolytica Glycolytic Enzyme Enolase: The Metabolic Regulation of Cytosine-5 Methyltransferase 2 (Dnmt2) Activity
A Tovy, R Siman Tov, R Gaentzsch, M Helm, S Ankri
PLoS pathogens 6 (2), e1000775, 2010
832010
p53 is essential for DNA methylation homeostasis in naive embryonic stem cells, and its loss promotes clonal heterogeneity
A Tovy, A Spiro, R McCarthy, Z Shipony, Y Aylon, K Allton, E Ainbinder, ...
Genes & development 31 (10), 959-972, 2017
662017
Glucose Starvation Boosts Entamoeba histolytica Virulence
A Tovy, R Hertz, R Siman-Tov, S Syan, D Faust, N Guillen, S Ankri
PLoS neglected tropical diseases 5 (8), e1247, 2011
512011
The disordered N-terminal domain of DNMT3A recognizes H2AK119ub and is required for postnatal development
T Gu, D Hao, J Woo, TW Huang, L Guo, X Lin, AG Guzman, A Tovy, ...
Nature genetics 54 (5), 625-636, 2022
342022
Systematic Profiling of DNMT3A Variants Reveals Protein Instability Mediated by the DCAF8 E3 Ubiquitin Ligase Adaptor
YH Huang, CW Chen, V Sundaramurthy, M Słabicki, D Hao, CJ Watson, ...
Cancer discovery 12 (1), 220-235, 2022
332022
The Entamoeba histolytica Dnmt2 homolog (Ehmeth) confers resistance to nitrosative stress
R Hertz, A Tovy, M Kirschenbaum, M Geffen, T Nozaki, N Adir, S Ankri
Eukaryotic Cell 13 (4), 494-503, 2014
332014
Lats2 is critical for the pluripotency and proper differentiation of stem cells
Y Aylon, A Sarver, A Tovy, E Ainbinder, M Oren
Cell Death & Differentiation 21 (4), 624-633, 2014
302014
Tissue-biased expansion of DNMT3A-mutant clones in a mosaic individual is associated with conserved epigenetic erosion
A Tovy, JM Reyes, MC Gundry, L Brunetti, H Lee-Six, M Petljak, HJ Park, ...
Cell Stem Cell 27 (2), 326-335. e4, 2020
262020
In vitro tRNA methylation assay with the Entamoeba histolytica DNA and tRNA methyltransferase Dnmt2 (Ehmeth) enzyme
A Tovy, B Hofmann, M Helm, S Ankri
JoVE (Journal of Visualized Experiments), e2390, 2010
242010
Perturbed hematopoiesis in individuals with germline DNMT3A overgrowth Tatton-Brown-Rahman syndrome
A Tovy, C Rosas, AS Gaikwad, G Medrano, L Zhang, JM Reyes, ...
Haematologica, 2021
162021
Structure analysis of Entamoeba histolytica enolase
EC Schulz, M Tietzel, A Tovy, S Ankri, R Ficner
Acta Crystallographica Section D: Biological Crystallography 67 (7), 619-627, 2011
152011
Constitutive loss of DNMT3A causes morbid obesity through misregulation of adipogenesis
A Tovy, JM Reyes, L Zhang, YH Huang, C Rosas, AC Daquinag, ...
Elife 11, e72359, 2022
142022
Epigenetics in the unicellular parasite Entamoeba histolytica
A Tovy, S Ankri
Future microbiology 5 (12), 1875-1884, 2010
142010
DNMT3A-coordinated splicing governs the stem state switch towards differentiation in embryonic and haematopoietic stem cells
R Ramabadran, JH Wang, JM Reyes, AG Guzman, S Gupta, C Rosas, ...
Nature cell biology 25 (4), 528-539, 2023
102023
The Entamoeba histolytica methylated LINE‐binding protein EhMLBP provides protection against heat shock
S Katz, O Kushnir, A Tovy, R Siman Tov, S Ankri
Cellular Microbiology 14 (1), 58-70, 2012
82012
SRCAP mutations drive clonal hematopoiesis through epigenetic and DNA repair dysregulation
CW Chen, L Zhang, R Dutta, A Niroula, PG Miller, CJ Gibson, AG Bick, ...
Cell Stem Cell 30 (11), 1503-1519. e8, 2023
42023
Nearly a Third of Clonal Hematopoiesis-Associated DNMT3A Mutations Reduce Protein Stability and May be Associated with Poorer Prognosis
YH Huang, A Tovy, V Sundaramurthy, J Su, J Hsu, L He, A Guzman, ...
Blood 132, 1315, 2018
22018
Hematologic DNMT3A reduction and high-fat diet synergize to promote weight gain and tissue inflammation
JM Reyes, A Tovy, L Zhang, AS Bortoletto, C Rosas, CW Chen, ...
Iscience 27 (3), 2024
2024
SRCAP mutations drive clonal hematopoiesis through epigenetic and DNA repair dysregulation
CW Chen, L Zhang, R Dutta, A Niroula, PG Miller, CJ Gibson, AG Bick, ...
Cell Stem Cell 31 (2), 275-277, 2024
2024
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