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Simhadri VR
Simhadri VR
Senior Staff Fellow, Food and Drug Administration
Dirección de correo verificada de fda.hhs.gov
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Human leukocyte antigen-B-associated transcript 3 is released from tumor cells and engages the NKp30 receptor on natural killer cells
EP von Strandmann, VR Simhadri, B von Tresckow, S Sasse, KS Reiners, ...
Immunity 27 (6), 965-974, 2007
4262007
Human leukocyte antigen-B-associated transcript 3 is released from tumor cells and engages the NKp30 receptor on natural killer cells
EP von Strandmann, VR Simhadri, B von Tresckow, S Sasse, KS Reiners, ...
Immunity 27 (6), 965-974, 2007
4262007
Dendritic cells release HLA-B-associated transcript-3 positive exosomes to regulate natural killer function
VR Simhadri, KS Reiners, HP Hansen, D Topolar, VL Simhadri, ...
PloS one 3 (10), e3377, 2008
2792008
Soluble ligands for NK cell receptors promote evasion of chronic lymphocytic leukemia cells from NK cell anti-tumor activity
KS Reiners, D Topolar, A Henke, VR Simhadri, J Kessler, M Sauer, ...
Blood, The Journal of the American Society of Hematology 121 (18), 3658-3665, 2013
2332013
Human CD300a binds to phosphatidylethanolamine and phosphatidylserine, and modulates the phagocytosis of dead cells
VR Simhadri, JF Andersen, E Calvo, SC Choi, JE Coligan, F Borrego
Blood, The Journal of the American Society of Hematology 119 (12), 2799-2809, 2012
1702012
A novel bispecific protein (ULBP2-BB4) targeting the NKG2D receptor on natural killer (NK) cells and CD138 activates NK cells and has potent antitumor activity against human …
EP von Strandmann, HP Hansen, KS Reiners, R Schnell, P Borchmann, ...
Blood 107 (5), 1955-1962, 2006
1672006
Cutting edge: mouse CD300f (CMRF-35–like molecule-1) recognizes outer membrane-exposed phosphatidylserine and can promote phagocytosis
SC Choi, VR Simhadri, L Tian, A Gil-Krzewska, K Krzewski, F Borrego, ...
The Journal of Immunology 187 (7), 3483-3487, 2011
932011
The biology and disease relevance of CD300a, an inhibitory receptor for phosphatidylserine and phosphatidylethanolamine
O Zenarruzabeitia, J Vitallé, C Eguizabal, VR Simhadri, F Borrego
The Journal of Immunology 194 (11), 5053-5060, 2015
792015
Heat shock protein 90 inhibitor BIIB021 (CNF2024) depletes NF-κB and sensitizes Hodgkin's lymphoma cells for natural killer cell–mediated cytotoxicity
B Böll, F Eltaib, KS Reiners, B von Tresckow, S Tawadros, VR Simhadri, ...
Clinical Cancer Research 15 (16), 5108-5116, 2009
682009
A human anti-M2 antibody mediates antibody-dependent cell-mediated cytotoxicity (ADCC) and cytokine secretion by resting and cytokine-preactivated natural killer (NK) cells
VR Simhadri, M Dimitrova, JL Mariano, O Zenarruzabeitia, W Zhong, ...
PloS one 10 (4), e0124677, 2015
592015
Dynamin interacts with members of the sumoylation machinery
RK Mishra, SS Jatiani, A Kumar, VR Simhadri, RV Hosur, R Mittal
Journal of Biological Chemistry 279 (30), 31445-31454, 2004
542004
CD300a is expressed on human B cells, modulates BCR-mediated signaling, and its expression is down-regulated in HIV infection
R Silva, S Moir, L Kardava, K Debell, VR Simhadri, S Ferrando-Martínez, ...
Blood, The Journal of the American Society of Hematology 117 (22), 5870-5880, 2011
532011
Human Th1 cells that express CD300a are polyfunctional and after stimulation up-regulate the T-box transcription factor eomesodermin
S Narayanan, R Silva, G Peruzzi, Y Alvarez, VR Simhadri, K Debell, ...
PLoS One 5 (5), e10636, 2010
452010
TNF-α-converting enzyme (TACE/ADAM17)-dependent loss of CD30 induced by proteasome inhibition through reactive oxygen species
AM Vahdat, KS Reiners, VL Simhadri, DA Eichenauer, B Böll, A Chalaris, ...
Leukemia 24 (1), 51-57, 2010
372010
The expression and function of human CD300 receptors on blood circulating mononuclear cells are distinct in neonates and adults
O Zenarruzabeitia, J Vitallé, S García-Obregón, I Astigarraga, C Eguizabal, ...
Scientific reports 6 (1), 32693, 2016
352016
CD300c is an activating receptor expressed on human monocytes
VR Simhadri, JL Mariano, A Gil-Krzewska, Q Zhou, F Borrego
Journal of Innate Immunity 5 (4), 389-400, 2013
272013
Differential expression of CD300a/c on human TH1 and TH17 cells
VR Simhadri, JL Mariano, Q Zhou, KE DeBell, F Borrego
BMC immunology 12, 1-11, 2011
272011
Functional requirements for inhibitory signal transmission by the immunomodulatory receptor CD300a
KE DeBell, VR Simhadri, JL Mariano, F Borrego
BMC immunology 13, 1-12, 2012
252012
CD300c is uniquely expressed on CD56bright Natural Killer Cells and differs from CD300a upon ligand recognition
M Dimitrova, O Zenarruzabeitia, F Borrego, VR Simhadri
Scientific Reports 6 (1), 23942, 2016
232016
A novel role for reciprocal CD30-CD30L signaling in the cross-talk between natural killer and dendritic cells
VL Simhadri, HP Hansen, VR Simhadri, KS Reiners, M Bessler, A Engert, ...
Biological Chemistry 393 (1-2), 101-106, 2012
202012
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Artículos 1–20