| In vivo genome editing via CRISPR/Cas9 mediated homology-independent targeted integration K Suzuki, Y Tsunekawa, R Hernandez-Benitez, J Wu, J Zhu, EJ Kim, ... Nature 540 (7631), 144-149, 2016 | 1165 | 2016 |
| Efficacy of tumor-targeting Salmonella typhimurium A1-R in combination with anti-angiogenesis therapy on a pancreatic cancer patient-derived orthotopic xenograft (PDOX) and … Y Hiroshima, Y Zhang, T Murakami, A Maawy, S Miwa, M Yamamoto, ... Oncotarget 5 (23), 12346, 2014 | 162 | 2014 |
| Single-dose CRISPR–Cas9 therapy extends lifespan of mice with Hutchinson–Gilford progeria syndrome E Beyret, HK Liao, M Yamamoto, R Hernandez-Benitez, Y Fu, G Erikson, ... Nature medicine 25 (3), 419-422, 2019 | 153 | 2019 |
| Establishment of a patient-derived orthotopic Xenograft (PDOX) model of HER-2-positive cervical cancer expressing the clinical metastatic pattern Y Hiroshima, Y Zhang, N Zhang, A Maawy, S Mii, M Yamamoto, F Uehara, ... PloS one 10 (2), e0117417, 2015 | 137 | 2015 |
| In vivo reprogramming of wound-resident cells generates skin epithelial tissue M Kurita, T Araoka, T Hishida, DD O’keefe, Y Takahashi, A Sakamoto, ... Nature 561 (7722), 243-247, 2018 | 122 | 2018 |
| In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice KC Browder, P Reddy, M Yamamoto, A Haghani, IG Guillen, S Sahu, ... Nature Aging 2 (3), 243-253, 2022 | 118 | 2022 |
| Efficacy of Tumor-Targeting Salmonella A1-R on a Melanoma Patient-Derived Orthotopic Xenograft (PDOX) Nude-Mouse Model M Yamamoto, M Zhao, Y Hiroshima, Y Zhang, E Shurell, FC Eilber, ... PLoS One 11 (8), e0160882, 2016 | 113 | 2016 |
| Tumor-targeting Salmonella typhimurium A1-R arrests a chemo-resistant patient soft-tissue sarcoma in nude mice Y Hiroshima, M Zhao, Y Zhang, N Zhang, A Maawy, T Murakami, S Mii, ... PloS one 10 (8), e0134324, 2015 | 101 | 2015 |
| Invading cancer cells are predominantly in G0/G1 resulting in chemoresistance demonstrated by real-time FUCCI imaging S Yano, S Miwa, S Mii, Y Hiroshima, F Uehara, M Yamamoto, H Kishimoto, ... Cell Cycle 13 (6), 953-960, 2014 | 100 | 2014 |
| Patient-derived orthotopic xenograft (PDOX) nude mouse model of soft-tissue sarcoma more closely mimics the patient behavior in contrast to the subcutaneous ectopic model Y Hiroshima, Y Zhang, N Zhang, F Uehara, A Maawy, T Murakami, S Mii, ... Anticancer research 35 (2), 697-701, 2015 | 92 | 2015 |
| Spatial–temporal FUCCI imaging of each cell in a tumor demonstrates locational dependence of cell cycle dynamics and chemoresponsiveness S Yano, Y Zhang, S Miwa, Y Tome, Y Hiroshima, F Uehara, M Yamamoto, ... Cell Cycle 13 (13), 2110-2119, 2014 | 87 | 2014 |
| Tumor-Targeting Salmonella typhimurium A1-R in Combination with Trastuzumab Eradicates HER-2-Positive Cervical Cancer Cells in Patient-Derived Mouse Models Y Hiroshima, Y Zhang, M Zhao, N Zhang, T Murakami, A Maawy, S Mii, ... PloS one 10 (6), e0120358, 2015 | 75 | 2015 |
| Intraperitoneal administration of tumor-targeting Salmonella typhimurium A1-R inhibits disseminated human ovarian cancer and extends survival in nude mice Y Matsumoto, S Miwa, Y Zhang, M Zhao, S Yano, F Uehara, M Yamamoto, ... Oncotarget 6 (13), 11369, 2015 | 73 | 2015 |
| Efficacy of Tumor‐Targeting Salmonella Typhimurium A1‐R on Nude Mouse Models of Metastatic and Disseminated Human Ovarian Cancer Y Matsumoto, S Miwa, Y Zhang, Y Hiroshima, S Yano, F Uehara, ... Journal of Cellular Biochemistry 115 (11), 1996-2003, 2014 | 70 | 2014 |
| Antitumor effects of a water-soluble extract from Maitake (Grifola frondosa) on human gastric cancer cell lines K Shomori, M Yamamoto, I Arifuku, K Teramachi, H Ito Oncology reports 22 (3), 615-620, 2009 | 70 | 2009 |
| RECK forms cowbell-shaped dimers and inhibits matrix metalloproteinase-catalyzed cleavage of fibronectin A Omura, T Matsuzaki, K Mio, T Ogura, M Yamamoto, A Fujita, K Okawa, ... Journal of biological chemistry 284 (6), 3461-3469, 2009 | 67 | 2009 |
| Precise in vivo genome editing via single homology arm donor mediated intron-targeting gene integration for genetic disease correction K Suzuki, M Yamamoto, R Hernandez-Benitez, Z Li, C Wei, RD Soligalla, ... Cell research 29 (10), 804-819, 2019 | 58 | 2019 |
| Color-coding cancer and stromal cells with genetic reporters in a patient-derived orthotopic xenograft (PDOX) model of pancreatic cancer enhances fluorescence-guided surgery S Yano, Y Hiroshima, A Maawy, H Kishimoto, A Suetsugu, S Miwa, ... Cancer Gene Therapy 22 (7), 344-350, 2015 | 58 | 2015 |
| Targeting tumors with a killer-reporter adenovirus for curative fluorescence-guided surgery of soft-tissue sarcoma S Yano, S Miwa, H Kishimoto, F Uehara, H Tazawa, M Toneri, ... Oncotarget 6 (15), 13133, 2015 | 53 | 2015 |
| Involvement of the Reck tumor suppressor protein in maternal and embryonic vascular remodeling in mice EPS Chandana, Y Maeda, A Ueda, H Kiyonari, N Oshima, M Yamamoto, ... BMC developmental biology 10, 1-13, 2010 | 53 | 2010 |
