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Sreedhara Alavattam
Sreedhara Alavattam
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Charge variants in IgG1: isolation, characterization, in vitro binding properties and pharmacokinetics in rats
LA Khawli, S Goswami, R Hutchinson, ZW Kwong, J Yang, X Wang, Z Yao, ...
MAbs 2 (6), 613-624, 2010
4282010
Catalytic hydrolysis of DNA by metal ions and complexes
A Sreedhara, JA Cowan
JBIC Journal of Biological Inorganic Chemistry 6, 337-347, 2001
3402001
Efficient inorganic deoxyribonucleases. Greater than 50-million-fold rate enhancement in enzyme-like DNA cleavage
A Sreedhara, JD Freed, JA Cowan
Journal of the American Chemical Society 122 (37), 8814-8824, 2000
2742000
Establishing a link between amino acid sequences and self-associating and viscoelastic behavior of two closely related monoclonal antibodies
S Yadav, A Sreedhara, S Kanai, J Liu, S Lien, H Lowman, DS Kalonia, ...
Pharmaceutical research 28, 1750-1764, 2011
1462011
Ligating DNA with DNA
A Sreedhara, Y Li, RR Breaker
Journal of the American Chemical Society 126 (11), 3454-3460, 2004
1272004
Alkoxo bound monooxo-and dioxovanadium (V) complexes: synthesis, characterization, X-ray crystal structures, and solution reactivity studies
G Asgedom, A Sreedhara, J Kivikoski, J Valkonen, E Kolehmainen, ...
Inorganic chemistry 35 (19), 5674-5683, 1996
1101996
Structural and catalytic roles for divalent magnesium in nucleic acid biochemistry
A Sreedhara, JA Cowan
Biometals 15 (3), 211-223, 2002
1032002
A novel in vitro method to model the fate of subcutaneously administered biopharmaceuticals and associated formulation components
HM Kinnunen, V Sharma, LR Contreras-Rojas, Y Yu, C Alleman, ...
Journal of Controlled Release 214, 94-102, 2015
912015
A new roadmap for biopharmaceutical drug product development: Integrating development, validation, and quality by design
S Martin‐Moe, FJ Lim, RL Wong, A Sreedhara, J Sundaram, SU Sane
Journal of pharmaceutical sciences 100 (8), 3031-3043, 2011
872011
Stability of IgG1 monoclonal antibodies in intravenous infusion bags under clinical in-use conditions
A Sreedhara, ZK Glover, N Piros, N Xiao, A Patel, B Kabakoff
Journal of pharmaceutical sciences 101 (1), 21-30, 2012
852012
Effect of ambient light on IgG1 monoclonal antibodies during drug product processing and development
A Sreedhara, J Yin, M Joyce, K Lau, AT Wecksler, G Deperalta, L Yi, ...
European Journal of Pharmaceutics and Biopharmaceutics 100, 38-46, 2016
752016
Synthesis and characterization of vanadyl (IV) complexes of Schiff bases derived from anthranilic acid and salicylaldehyde (or its derivatives) or acetylacetone. Single crystal …
G Asgedom, A Sreedhara, J Kivikoski, CP Rao
Polyhedron 16 (4), 643-651, 1997
681997
Compatibility and stability of pertuzumab and trastuzumab admixtures in iv infusion bags for coadministration
ZWK Glover, L Gennaro, S Yadav, B Demeule, PY Wong, A Sreedhara
Journal of pharmaceutical sciences 102 (3), 794-812, 2013
662013
Characterization of the isomerization products of aspartate residues at two different sites in a monoclonal antibody
A Sreedhara, A Cordoba, Q Zhu, J Kwong, J Liu
Pharmaceutical research 29, 187-197, 2012
662012
Structure, characterization and photoreactivity of monomeric dioxovanadium (V) Schiff-base complexes of trigonal-bipyramidal geometry
G Asgedom, A Sreedhara, J Kivikoski, E Kolehmainen, CP Rao
Journal of the Chemical Society, Dalton Transactions, 93-97, 1996
661996
Syntheses, structure, reactivity and species recognition studies of oxo-vanadium (V) and-molybdenum (VI) complexes
CP Rao, P áVenkateswara Rao, M áBindu Verghese, ...
Journal of the Chemical Society, Dalton Transactions, 2383-2394, 1998
631998
Role of surface exposed tryptophan as substrate generators for the antibody catalyzed water oxidation pathway
A Sreedhara, K Lau, C Li, B Hosken, F Macchi, D Zhan, A Shen, ...
Molecular Pharmaceutics 10 (1), 278-288, 2013
582013
Biodegradable microparticles that stabilize and control the release of proteins
S Alavattam, RS Brody
US Patent 7,060,299, 2006
562006
Transition metal saccharide chemistry and biology: syntheses, characterization, solution stability and putative bio-relevant studies of iron–saccharide complexes
CP Rao, K Geetha, MSS Raghavan, A Sreedhara, K Tokunaga, ...
Inorganica Chimica Acta 297 (1-2), 373-382, 2000
542000
Metal ion interactions with mAbs: Part 1: pH and conformation modulate copper-mediated site-specific fragmentation of the IgG1 hinge region
ZK Glover, L Basa, B Moore, JS Laurence, A Sreedhara
MAbs 7 (5), 901-911, 2015
522015
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Artículos 1–20