| Lipases: Useful biocatalysts for the preparation of pharmaceuticals V Gotor-Fernández, R Brieva, V Gotor Journal of Molecular Catalysis B: Enzymatic 40 (3-4), 111-120, 2006 | 487 | 2006 |
| Chemoenzymic synthesis of the C-13 side chain of taxol: optically active 3-hydroxy-4-phenyl. beta.-lactam derivatives R Brieva, JZ Crich, CJ Sih The Journal of Organic Chemistry 58 (5), 1068-1075, 1993 | 198 | 1993 |
| Enzymatic aminolysis and transamidation reactions V Gotor, R Brieva, C González, F Rebolledo Tetrahedron 47 (44), 9207-9214, 1991 | 109 | 1991 |
| Enzymic asymmetric synthesis of. alpha.-amino acids. Enantioselective cleavage of 4-substituted oxazolin-5-ones and thiazolin-5-ones JZ Crich, R Brieva, P Marquart, RL Gu, S Flemming, CJ Sih The Journal of Organic Chemistry 58 (12), 3252-3258, 1993 | 97 | 1993 |
| Lipase catalyzed aminolysis of ethyl propiolate and acrylic esters. Synthesis of chiral acrylamides S Puertas, R Brieva, F Robelledo, V Gotor Tetrahedron 49 (19), 4007-4014, 1993 | 93 | 1993 |
| Chemoenzymatic synthesis of (S)-2-cyanopiperidine, a key intermediate in the route to (S)-pipecolic acid and 2-substituted piperidine alkaloids S Nazabadioko, RJ Pérez, R Brieva, V Gotor Tetrahedron: Asymmetry 9 (9), 1597-1604, 1998 | 69 | 1998 |
| Enzymatic resolution of trans-4-(4‘-fluorophenyl)-3-hydroxymethylpiperidines, key intermediates in the synthesis of (−)-paroxetine G de Gonzalo, R Brieva, VM Sánchez, M Bayod, V Gotor The Journal of Organic Chemistry 66 (26), 8947-8953, 2001 | 61 | 2001 |
| Chemoenzymatic synthesis of azacycloalkan-3-ols MI Monterde, S Nazabadioko, F Rebolledo, R Brieva, V Gotor Tetrahedron: Asymmetry 10 (17), 3449-3455, 1999 | 61 | 1999 |
| Lipase-catalyzed synthesis of optically active amides in organic media M Quirós, VM Sánchez, R Brieva, F Rebolledo, V Gotor Tetrahedron: Asymmetry 4 (6), 1105-1112, 1993 | 60 | 1993 |
| A simple procedure for the preparation of chiral amides V Gotor, R Brieva, F Rebolledo Tetrahedron letters 29 (52), 6973-6974, 1988 | 54 | 1988 |
| Enzymatic resolution of new carbonate intermediates for the synthesis of (S)-(+)-zopiclone LF Solares, M Dı́az, R Brieva, VM Sánchez, M Bayod, V Gotor Tetrahedron: Asymmetry 13 (23), 2577-2582, 2002 | 49 | 2002 |
| Enzymatic resolution of (±)-6-(5-chloropyridin-2-yl)-6-vinyloxy-carbonyloxy-6,7-dihydro[5H]pyrrolo[3,4-b]pyrazin-5-one. Synthesis of (+)-zopiclone V Gotor, F Limeres, R García, M Bayod, R Brieva Tetrahedron: Asymmetry 8 (7), 995-997, 1997 | 48 | 1997 |
| Enantioselective acylation of amino alcohols by porcine pancreatic lipase V Gotor, R Brieva, F Rebolledo Journal of the Chemical Society, Chemical Communications, 957-958, 1988 | 46 | 1988 |
| Stereocontrolled chemoenzymatic synthesis of 2, 3-disubstituted piperidines MI Monterde, R Brieva, V Gotor Tetrahedron: Asymmetry 12 (3), 525-528, 2001 | 43 | 2001 |
| Enzymatic resolution of a quaternary stereogenic centre as the key step in the synthesis of (S)-(+)-citalopram LF Solares, R Brieva, M Quirós, I Llorente, M Bayod, V Gotor Tetrahedron: Asymmetry 15 (2), 341-345, 2004 | 42 | 2004 |
| Anhydrides as acylating agents in the enzymatic resolution of an intermediate of (−)-paroxetine G de Gonzalo, R Brieva, VM Sánchez, M Bayod, V Gotor The Journal of Organic Chemistry 68 (8), 3333-3336, 2003 | 41 | 2003 |
| Preparation of mono-and diacylglycerols by enzymatic esterification of glycerol with conjugated linoleic acid in hexane CE Martinez, JC Vinay, R Brieva, CG Hill, HS Garcia Applied biochemistry and biotechnology 125, 63-75, 2005 | 37 | 2005 |
| Lipase-catalysed enantioselective acylation of N-protected or unprotected 2-aminoalkan-1-ols S Fernández, R Brieva, F Rebolledo, V Gotor Journal of the Chemical Society, Perkin Transactions 1, 2885-2889, 1992 | 36 | 1992 |
| Optically active (S)-ketone-and (R)-aldehyde-cyanohydrins via an (R)-oxynitrifase-catalysed transcyanation. Chemoenzymatic syntheses of 2-cyanotetrahydrofuran and 2 … E Menéndez, R Brieva, F Rebolledo, V Gotor Journal of the Chemical Society, Chemical Communications, 989-990, 1995 | 34 | 1995 |
| Optically active (S)-ketone-and (R)-aldehyde-cyanohydrins via an (R)-oxynitrifase-catalysed transcyanation. Chemoenzymatic syntheses of 2-cyanotetrahydrofuran and 2 … E Menéndez, R Brieva, F Rebolledo, V Gotor Journal of the Chemical Society, Chemical Communications, 989-990, 1995 | 33 | 1995 |
