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Henry Lowman
Henry Lowman
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Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index
JR Junutula, H Raab, S Clark, S Bhakta, DD Leipold, S Weir, Y Chen, ...
Nature biotechnology 26 (8), 925-932, 2008
14492008
Selection and analysis of an optimized anti-VEGF antibody: crystal structure of an affinity-matured Fab in complex with antigen
Y Chen, C Wiesmann, G Fuh, B Li, HW Christinger, P McKay, AM de Vos, ...
Journal of molecular biology 293 (4), 865-881, 1999
11261999
Development of ranibizumab, an anti–vascular endothelial growth factor antigen binding fragment, as therapy for neovascular age-related macular degeneration
N Ferrara, L Damico, N Shams, H Lowman, R Kim
Retina 26 (8), 859-870, 2006
10762006
Enrichment method for variant proteins having altered binding properties, M13 phagemids, and growth hormone variants
LJ Garrard, DJ Henner, S Bass, R Greene, HB Lowman, JA Wells, ...
US Patent 5,750,373, 1998
9921998
FIZZ1, a novel cysteine‐rich secreted protein associated with pulmonary inflammation, defines a new gene family
IN Holcomb, RC Kabakoff, B Chan, TW Baker, A Gurney, W Henzel, ...
The EMBO journal, 2000
9642000
Cysteine engineered antibodies and conjugates
CW Eigenbrot, JR Junutula, H Lowman, HE Raab, R Vandlen
US Patent 7,521,541, 2009
7972009
Monovalent phage display
LJ Garrard, DJ Henner, S Bass, R Greene, HB Lowman, JA Wells, ...
US Patent 5,821,047, 1998
7091998
Selecting high-affinity binding proteins by monovalent phage display
HB Lowman, SH Bass, N Simpson, JA Wells
Biochemistry 30 (45), 10832-10838, 1991
6431991
[21] Phage display for selection of novel binding peptides
SS Sidhu, HB Lowman, BC Cunningham, JA Wells
Methods in enzymology 328, 333-IN5, 2000
6392000
VEGF and the Fab fragment of a humanized neutralizing antibody: crystal structure of the complex at 2.4 Å resolution and mutational analysis of the interface
YA Muller, Y Chen, HW Christinger, B Li, BC Cunningham, HB Lowman, ...
Structure 6 (9), 1153-1167, 1998
3971998
Engineering human IgG1 affinity to human neonatal Fc receptor: impact of affinity improvement on pharmacokinetics in primates
YA Yeung, MK Leabman, JS Marvin, J Qiu, CW Adams, S Lien, ...
The Journal of Immunology 182 (12), 7663-7671, 2009
3552009
Bacteriophage display and discovery of peptide leads for drug development
HB Lowman
Annual review of biophysics and biomolecular structure 26 (1), 401-424, 1997
3541997
Affinity maturation of human growth hormone by monovalent phage display
HB Lowman, JA Wells
Journal of molecular biology 234 (3), 564-578, 1993
3291993
Therapeutic peptides
S Lien, HB Lowman
Trends in biotechnology 21 (12), 556-562, 2003
2952003
Tumor-specific activation of an EGFR-targeting probody enhances therapeutic index
LR Desnoyers, O Vasiljeva, JH Richardson, A Yang, EEM Menendez, ...
Science translational medicine 5 (207), 207ra144-207ra144, 2013
2892013
Interaction between bevacizumab and murine VEGF-A: a reassessment
L Yu, X Wu, Z Cheng, CV Lee, J LeCouter, C Campa, G Fuh, H Lowman, ...
Investigative ophthalmology & visual science 49 (2), 522-527, 2008
2842008
Anti-VEGF antibodies
M Baca, JA Wells, LG Presta, HB Lowman, YM Chen
US Patent 7,169,901, 2007
2592007
Human growth hormone variants
BC Cunningham, HB Lowman, JA Wells, RG Clark, K Olson, GG Fuh
US Patent 5,849,535, 1998
2341998
Structure of a CXC chemokine-receptor fragment in complex with interleukin-8
NJ Skelton, C Quan, D Reilly, H Lowman
Structure 7 (2), 157-168, 1999
2321999
Rapid identification of reactive cysteine residues for site-specific labeling of antibody-Fabs
JR Junutula, S Bhakta, H Raab, KE Ervin, C Eigenbrot, R Vandlen, ...
Journal of immunological methods 332 (1-2), 41-52, 2008
2212008
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