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Guy Berchem MD, PhD
Guy Berchem MD, PhD
Medical Oncologist CHL and Ass. Medical Director Luxembourg Institute of Health
Dirección de correo verificada de chl.lu
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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif, A Abdoli, S Abel, ...
autophagy 17 (1), 1-382, 2021
13067*2021
First-Line Crizotinib versus Chemotherapy in ALK-Positive Lung Cancer
BJ Solomon, T Mok, DW Kim, YL Wu, K Nakagawa, T Mekhail, E Felip, ...
New England Journal of Medicine 371 (23), 2167-2177, 2014
35312014
Cetuximab plus chemotherapy in patients with advanced non-small-cell lung cancer (FLEX): an open-label randomised phase III trial
R Pirker, JR Pereira, A Szczesna, J von Pawel, M Krzakowski, R Ramlau, ...
The Lancet 373 (9674), 1525-1531, 2009
18022009
Exosomes released by chronic lymphocytic leukemia cells induce the transition of stromal cells into cancer-associated fibroblasts
J Paggetti, F Haderk, M Seiffert, B Janji, U Distler, W Ammerlaan, YJ Kim, ...
Blood, The Journal of the American Society of Hematology 126 (9), 1106-1117, 2015
4842015
Cathepsin-D affects multiple tumor progression steps in vivo: proliferation, angiogenesis and apoptosis
G Berchem, M Glondu, M Gleizes, JP Brouillet, F Vignon, M Garcia, ...
Oncogene 21 (38), 5951-5955, 2002
3322002
A secreted FGF-binding protein can serve as the angiogenic switch in human cancer
F Czubayko, EDE Liaudet-Coopman, A Aigner, AT Tuveson, GJ Berchem, ...
Nature medicine 3 (10), 1137-1140, 1997
3101997
Granzyme B degradation by autophagy decreases tumor cell susceptibility to natural killer-mediated lysis under hypoxia
J Baginska, E Viry, G Berchem, A Poli, MZ Noman, K van Moer, S Medves, ...
Proceedings of the National Academy of Sciences 110 (43), 17450-17455, 2013
3072013
Hypoxic tumor-derived microvesicles negatively regulate NK cell function by a mechanism involving TGF-β and miR23a transfer
G Berchem, MZ Noman, M Bosseler, J Paggetti, S Baconnais, E Le Cam, ...
Oncoimmunology 5 (4), e1062968, 2016
2932016
Blocking hypoxia-induced autophagy in tumors restores cytotoxic T-cell activity and promotes regression
MZ Noman, B Janji, B Kaminska, K Van Moer, S Pierson, P Przanowski, ...
Cancer research 71 (18), 5976-5986, 2011
2682011
MicroRNA as biomarkers and regulators in B-cell chronic lymphocytic leukemia
E Moussay, K Wang, JH Cho, K van Moer, S Pierson, J Paggetti, ...
Proceedings of the National Academy of Sciences 108 (16), 6573-6578, 2011
2312011
Melanoma angiogenesis and metastasis modulated by ribozyme targeting of the secreted growth factor pleiotrophin
F Czubayko, AM Schulte, GJ Berchem, A Wellstein
Proceedings of the National Academy of Sciences 93 (25), 14753-14758, 1996
2191996
The critical role of the tumor microenvironment in shaping natural killer cell-mediated anti-tumor immunity
J Baginska, E Viry, J Paggetti, S Medves, G Berchem, E Moussay, B Janji
Frontiers in immunology 4, 73994, 2013
2162013
Androgens Induce Resistance to bcl-2-mediated Apoptosis in LNCaP Prostate Cancer Cells
GJ Berchem, M Bosseler, LVY Sugars, H James Voeller, S Zeitlin, ...
Cancer research 55 (4), 735-738, 1995
2131995
Challenges with advanced therapy medicinal products and how to meet them
Nature reviews Drug discovery 9 (3), 195-201, 2010
2102010
Targeting autophagy inhibits melanoma growth by enhancing NK cells infiltration in a CCL5-dependent manner
T Mgrditchian, T Arakelian, J Paggetti, MZ Noman, E Viry, E Moussay, ...
Proceedings of the National Academy of Sciences 114 (44), E9271-E9279, 2017
1952017
Assessing cellular and circulating miRNA recovery: the impact of the RNA isolation method and the quantity of input material
V El-Khoury, S Pierson, T Kaoma, F Bernardin, G Berchem
Scientific reports 6 (1), 19529, 2016
1832016
Inhibition of Vps34 reprograms cold into hot inflamed tumors and improves anti–PD-1/PD-L1 immunotherapy
MZ Noman, S Parpal, K Van Moer, M Xiao, Y Yu, T Arakelian, J Viklund, ...
Science advances 6 (18), eaax7881, 2020
1682020
Improving cancer immunotherapy by targeting the hypoxic tumor microenvironment: new opportunities and challenges
MZ Noman, M Hasmim, A Lequeux, M Xiao, C Duhem, S Chouaib, ...
Cells 8 (9), 1083, 2019
1612019
The acquisition of resistance to TNFα in breast cancer cells is associated with constitutive activation of autophagy as revealed by a transcriptome analysis using a custom …
E Moussay, T Kaoma, J Baginska, A Muller, K Van Moer, N Nicot, ...
Autophagy 7 (7), 760-770, 2011
1312011
Dual PD1/LAG3 immune checkpoint blockade limits tumor development in a murine model of chronic lymphocytic leukemia
M Wierz, S Pierson, L Guyonnet, E Viry, A Lequeux, A Oudin, SP Niclou, ...
Blood, The Journal of the American Society of Hematology 131 (14), 1617-1621, 2018
1202018
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