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Daulat Bikram Khadka
Daulat Bikram Khadka
Research Lab. Specialist Senior, University of Michigan
Dirección de correo verificada de umich.edu
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Pharmacological effects of berberine and its derivatives: a patent update
Y Jin, DB Khadka, WJ Cho
Expert opinion on therapeutic patents 26 (2), 229-243, 2016
1472016
A maresin 1/RORα/12-lipoxygenase autoregulatory circuit prevents inflammation and progression of nonalcoholic steatohepatitis
YH Han, KO Shin, JY Kim, DB Khadka, HJ Kim, YM Lee, WJ Cho, JY Cha, ...
The Journal of clinical investigation 129 (4), 1684-1698, 2019
1282019
Topoisomerase inhibitors as anticancer agents: a patent update
DB Khadka, WJ Cho
Expert opinion on therapeutic patents 23 (8), 1033-1056, 2013
912013
3-Arylisoquinolines as novel topoisomerase I inhibitors
DB Khadka, WJ Cho
Bioorganic & Medicinal Chemistry 19 (2), 724-734, 2011
682011
Virtual screening and synthesis of quinazolines as novel JAK2 inhibitors
SH Yang, DB Khadka, SH Cho, HK Ju, KY Lee, HJ Han, KT Lee, WJ Cho
Bioorganic & Medicinal Chemistry 19 (2), 968-977, 2011
602011
Structure-based Virtual Screening and Identification of a Novel Androgen Receptor Antagonist
CH Song, SH Yang, E Park, SH Cho, EY Gong, DB Khadka, WJ Cho, ...
Journal of Biological Chemistry 287 (36), 30769-30780, 2012
442012
SAR Based Design of Nicotinamides as a Novel Class of Androgen Receptor Antagonists for Prostate Cancer
SH Yang, CH Song, HTM Van, E Park, DB Khadka, EY Gong, K Lee, ...
Journal of medicinal chemistry 56 (8), 3414-3418, 2013
332013
Synthesis, in vitro and in vivo evaluation of 3-arylisoquinolinamines as potent antitumor agents
SH Yang, HTM Van, TN Le, DB Khadka, SH Cho, KT Lee, HJ Chung, ...
Bioorganic & medicinal chemistry letters 20 (17), 5277-5281, 2010
312010
Synthesis of 12-oxobenzo[c]phenanthridinones and 4-substituted 3-arylisoquinolones via Vilsmeier–Haack reaction
DB Khadka, SH Yang, SH Cho, C Zhao, WJ Cho
Tetrahedron 68 (1), 250-261, 2012
302012
Total synthesis of 8-oxypseudopalmatine and 8-oxypseudoberberine via ring-closing metathesis
HTM Van, SH Yang, DB Khadka, YC Kim, WJ Cho
Tetrahedron 65 (49), 10142-10148, 2009
302009
Synthesis of Aryl Trimethylstannane via BF3·OEt2-Mediated Cross-Coupling of Hexaalkyl Distannane Reagent with Aryl Triazene at Room Temperature
S Mao, Z Chen, L Wang, DB Khadka, M Xin, P Li, SQ Zhang
The Journal of organic chemistry 84 (1), 463-471, 2018
282018
Design, synthesis and systematic evaluation of cytotoxic 3-heteroarylisoquinolinamines as topoisomerases inhibitors
HTM Van, H Woo, HM Jeong, DB Khadka, SH Yang, C Zhao, Y Jin, ...
European journal of medicinal chemistry 82, 181-194, 2014
282014
Development of 3-aryl-1-isoquinolinamines as potent antitumor agents based on CoMFA
SH Yang, HTM Van, TN Le, DB Khadka, SH Cho, KT Lee, ES Lee, YB Lee, ...
European journal of medicinal chemistry 45 (11), 5493-5497, 2010
272010
Modification of 3-arylisoquinolines into 3, 4-diarylisoquinolines and assessment of their cytotoxicity and topoisomerase inhibition
DB Khadka, H Woo, SH Yang, C Zhao, Y Jin, TN Le, Y Kwon, WJ Cho
European journal of medicinal chemistry 92, 583-607, 2015
262015
Substituted 2-arylquinazolinones: Design, synthesis, and evaluation of cytotoxicity and inhibition of topoisomerases
DB Khadka, GH Tran, S Shin, HTM Nguyen, HT Cao, C Zhao, Y Jin, ...
European Journal of Medicinal Chemistry 103, 69-79, 2015
212015
Structure-based discovery of novel cyclophilin A inhibitors for the treatment of hepatitis C virus infections
S Yang, J KR, S Lim, TG Choi, JH Kim, S Akter, M Jang, HJ Ahn, HY Kim, ...
Journal of medicinal chemistry 58 (24), 9546-9561, 2015
202015
Berberine bioisostere Q8 compound stimulates osteoblast differentiation and function in vitro
Y Han, Y Jin, SH Lee, DB Khadka, WJ Cho, KY Lee
Pharmacological Research 119, 463-475, 2017
192017
Design and synthesis of 4-amino-2-phenylquinazolines as novel topoisomerase I inhibitors with molecular modeling
TN Le, SH Yang, DB Khadka, HTM Van, SH Cho, Y Kwon, ES Lee, ...
Bioorganic & medicinal chemistry 19 (14), 4399-4404, 2011
192011
Triple reuptake inhibitors: Design, synthesis and structure–activity relationship of benzylpiperidine–tetrazoles
S Paudel, X Min, S Acharya, DB Khadka, G Yoon, KM Kim, SH Cheon
Bioorganic & medicinal chemistry 25 (20), 5278-5289, 2017
172017
Synthesis of benzo [3,4] azepino [1,2-b] isoquinolin-9-ones from 3-arylisoquinolines via ring closing metathesis and evaluation of topoisomerase I inhibitory activity …
HTM Van, DB Khadka, SH Yang, TN Le, SH Cho, C Zhao, IS Lee, Y Kwon, ...
Bioorganic & medicinal chemistry 19 (18), 5311-5320, 2011
172011
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