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Christian Steinkuhler
Christian Steinkuhler
italfarmaco, Exiris
Dirección de correo verificada de italfarmaco.com
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Crystal structure of a eukaryotic zinc-dependent histone deacetylase, human HDAC8, complexed with a hydroxamic acid inhibitor
A Vannini, C Volpari, G Filocamo, EC Casavola, M Brunetti, D Renzoni, ...
Proceedings of the National Academy of Sciences 101 (42), 15064-15069, 2004
8032004
HDACs, histone deacetylation and gene transcription: from molecular biology to cancer therapeutics
P Gallinari, SD Marco, P Jones, M Pallaoro, C Steinkühler
Cell research 17 (3), 195-211, 2007
7412007
Unraveling the hidden catalytic activity of vertebrate class IIa histone deacetylases
A Lahm, C Paolini, M Pallaoro, MC Nardi, P Jones, P Neddermann, ...
Proceedings of the National Academy of Sciences 104 (44), 17335-17340, 2007
6372007
Histone deacetylase and Cullin3–RENKCTD11 ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation
G Canettieri, L Di Marcotullio, A Greco, S Coni, L Antonucci, P Infante, ...
Nature cell biology 12 (2), 132-142, 2010
3872010
Functional and morphological recovery of dystrophic muscles in mice treated with deacetylase inhibitors
GC Minetti, C Colussi, R Adami, C Serra, C Mozzetta, V Parente, S Fortuni, ...
Nature medicine 12 (10), 1147-1150, 2006
3802006
Structural and functional analysis of the human HDAC4 catalytic domain reveals a regulatory structural zinc-binding domain
MJ Bottomley, PL Surdo, P Di Giovine, A Cirillo, R Scarpelli, F Ferrigno, ...
Journal of Biological Chemistry 283 (39), 26694-26704, 2008
3782008
Complex of NS3 protease and NS4A peptide of BK strain hepatitis C virus: a 2.2 Å resolution structure in a hexagonal crystal form
Y Yan, Y Li, S Munshi, V Sardana, JL Cole, M Sardana, LC Kuo, Z Chen, ...
Protein Science 7 (4), 837-847, 1998
3521998
Product inhibition of the hepatitis C virus NS3 protease
C Steinkühler, G Biasiol, M Brunetti, A Urbani, U Koch, R Cortese, A Pessi, ...
Biochemistry 37 (25), 8899-8905, 1998
3121998
Substrate binding to histone deacetylases as shown by the crystal structure of the HDAC8–substrate complex
A Vannini, C Volpari, P Gallinari, P Jones, M Mattu, A Carfí, ...
EMBO reports 8 (9), 879-884, 2007
3042007
HDAC2 blockade by nitric oxide and histone deacetylase inhibitors reveals a common target in Duchenne muscular dystrophy treatment
C Colussi, C Mozzetta, A Gurtner, B Illi, J Rosati, S Straino, G Ragone, ...
Proceedings of the National Academy of Sciences 105 (49), 19183-19187, 2008
2792008
Multiple enzymatic activities associated with recombinant NS3 protein of hepatitis C virus
P Gallinari, D Brennan, C Nardi, M Brunetti, L Tomei, C Steinkühler, ...
Journal of virology 72 (8), 6758-6769, 1998
2601998
Potent peptide inhibitors of human hepatitis C virus NS3 protease are obtained by optimizing the cleavage products
P Ingallinella, S Altamura, E Bianchi, M Taliani, R Ingenito, R Cortese, ...
Biochemistry 37 (25), 8906-8914, 1998
2501998
A designed P1 cysteine mimetic for covalent and non-covalent inhibitors of HCV NS3 protease
F Narjes, KF Koehler, U Koch, B Gerlach, S Colarusso, C Steinkühler, ...
Bioorganic & medicinal chemistry letters 12 (4), 701-704, 2002
1982002
Activity of purified hepatitis C virus protease NS3 on peptide substrates
C Steinkühler, A Urbani, L Tomei, G Biasiol, M Sardana, E Bianchi, ...
Journal of virology 70 (10), 6694-6700, 1996
1891996
Inhibition of class I histone deacetylase with an apicidin derivative prevents cardiac hypertrophy and failure
P Gallo, MVG Latronico, P Gallo, S Grimaldi, F Borgia, M Todaro, P Jones, ...
Cardiovascular research 80 (3), 416-424, 2008
1822008
A continuous assay of hepatitis C virus protease based on resonance energy transfer depsipeptide substrates
M Taliani, E Bianchi, F Narjes, M Fossatelli, A Urbani, C Steinkühler, ...
Analytical biochemistry 240 (1), 60-67, 1996
1681996
In vitro selection and characterization of hepatitis C virus serine protease variants resistant to an active-site peptide inhibitor
C Trozzi, L Bartholomew, A Ceccacci, G Biasiol, L Pacini, S Altamura, ...
Journal of virology 77 (6), 3669-3679, 2003
1612003
PP2A regulates HDAC4 nuclear import
G Paroni, N Cernotta, C Dello Russo, P Gallinari, M Pallaoro, C Foti, ...
Molecular biology of the cell 19 (2), 655-667, 2008
1492008
The solution structure of the N-terminal proteinase domain of the hepatitis C virus (HCV) NS3 protein provides new insights into its activation and catalytic mechanism
G Barbato, DO Cicero, MC Nardi, C SteinkuÈhler, R Cortese, ...
Journal of molecular biology 289 (2), 371-384, 1999
1431999
Affinity selection of a camelized V (H) domain antibody inhibitor of hepatitis C virus NS3 protease.
F Martin, C Volpari, C Steinkuhler, N Dimasi, M Brunetti, G Biasiol, ...
Protein Engineering 10 (5), 607-614, 1997
1421997
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Artículos 1–20