| Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents RG Kurumbail, AM Stevens, JK Gierse, JJ McDonald, RA Stegeman, ... Nature 384 (6610), 644-648, 1996 | 2348 | 1996 |
| A single amino acid difference between cyclooxygenase-1 (COX-1) and− 2 (COX-2) reverses the selectivity of COX-2 specific inhibitors JK Gierse, JJ McDonald, SD Hauser, SH Rangwala, CM Koboldt, ... Journal of Biological Chemistry 271 (26), 15810-15814, 1996 | 573 | 1996 |
| Discovery of novel benzothiazolesulfonamides as potent inhibitors of HIV-1 protease SR Nagarajan, GA De Crescenzo, DP Getman, HF Lu, JA Sikorski, ... Bioorganic & medicinal chemistry 11 (22), 4769-4777, 2003 | 151 | 2003 |
| Assessment of docking poses: interactions-based accuracy classification (IBAC) versus crystal structure deviations RT Kroemer, A Vulpetti, JJ McDonald, DC Rohrer, JY Trosset, ... Journal of Chemical Information and Computer Sciences 44 (3), 871-881, 2004 | 150 | 2004 |
| Solution structure and backbone dynamics of the catalytic domain of matrix metalloproteinase-2 complexed with a hydroxamic acid inhibitor Y Feng, JJ Likos, L Zhu, H Woodward, G Munie, JJ McDonald, ... Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1598 (1-2), 10-23, 2002 | 110 | 2002 |
| Orally active MMP-1 sparing α-tetrahydropyranyl and α-piperidinyl sulfone matrix metalloproteinase (MMP) inhibitors with efficacy in cancer, arthritis, and cardiovascular disease DP Becker, TE Barta, LJ Bedell, TL Boehm, BR Bond, J Carroll, ... Journal of medicinal chemistry 53 (18), 6653-6680, 2010 | 108 | 2010 |
| Synthesis and structure− activity relationships of β-and α-piperidine sulfone hydroxamic acid matrix metalloproteinase inhibitors with oral antitumor efficacy DP Becker, CI Villamil, TE Barta, LJ Bedell, TL Boehm, GA DeCrescenzo, ... Journal of medicinal chemistry 48 (21), 6713-6730, 2005 | 81 | 2005 |
| Species differences in the carbohydrate binding preferences of surfactant protein D EC Crouch, K Smith, B McDonald, D Briner, B Linders, J McDonald, ... American journal of respiratory cell and molecular biology 35 (1), 84-94, 2006 | 78 | 2006 |
| Crystal structure of the SALL4–pomalidomide–cereblon–DDB1 complex ME Matyskiela, T Clayton, X Zheng, C Mayne, E Tran, A Carpenter, ... Nature Structural & Molecular Biology, 2020 | 71 | 2020 |
| Design of potent inhibitors of human β-secretase. Part 1 JN Freskos, YM Fobian, TE Benson, MJ Bienkowski, DL Brown, ... Bioorganic & Medicinal Chemistry Letters 17 (1), 73-77, 2007 | 68 | 2007 |
| Heteroaryl compounds and uses thereof LA D'agostino, RTT Sjin, D Niu, JJ McDonald, Z Zhu, LIU Haibo, ... US Patent 9,321,786, 2016 | 66* | 2016 |
| Discovery of potent inhibitors of soluble epoxide hydrolase by combinatorial library design and structure-based virtual screening L Xing, JJ McDonald, SA Kolodziej, RG Kurumbail, JM Williams, ... Journal of Medicinal Chemistry 54 (5), 1211-1222, 2011 | 60 | 2011 |
| Discovery of (pyridin-4-yl)-2H-tetrazole as a novel scaffold to identify highly selective matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis ME Schnute, PM O’Brien, J Nahra, M Morris, WH Roark, CE Hanau, ... Bioorganic & medicinal chemistry letters 20 (2), 576-580, 2010 | 58 | 2010 |
| Method of changing conformation of a matrix metalloproteinase WC Stallings, HS Shieh, SC Howard, GA DeCrescenzo, JJ McDonald US Patent 6,869,951, 2005 | 56 | 2005 |
| Evolution of Cereblon-Mediated Protein Degradation as a Therapeutic Modality PP Chamberlain, LA D'Agostino, JM Ellis, JD Hansen, ME Matyskiela, ... ACS Medicinal Chemistry Letters 10, 1592-1602, 2019 | 51 | 2019 |
| Imidazotriazines: Spleen tyrosine kinase (Syk) inhibitors identified by free‐energy perturbation (FEP) F Lovering, C Aevazelis, J Chang, C Dehnhardt, L Fitz, S Han, K Janz, ... ChemMedChem 11 (2), 217-233, 2016 | 45 | 2016 |
| Molecular dynamics analysis of binding of kinase inhibitors to WT EGFR and the T790M mutant J Park, JJ McDonald, RC Petter, KN Houk Journal of Chemical Theory and Computation 12 (4), 2066-2078, 2016 | 44 | 2016 |
| Discovery of a novel series of selective MMP inhibitors: Identification of the γ-sulfone-thiols JN Freskos, BV Mischke, GA DeCrescenzo, R Heintz, DP Getman, ... Bioorganic & medicinal chemistry letters 9 (7), 943-948, 1999 | 42 | 1999 |
| Synthesis and identification of conformationally constrained selective MMP inhibitors JN Freskos, JJ McDonald, BV Mischke, PB Mullins, HS Shieh, ... Bioorganic & medicinal chemistry letters 9 (13), 1757-1760, 1999 | 41 | 1999 |
| Discovery of novel spirocyclic inhibitors of fatty acid amide hydrolase (FAAH). Part 2. Discovery of 7-azaspiro [3.5] nonane urea PF-04862853, an orally efficacious inhibitor … MJ Meyers, SA Long, MJ Pelc, JL Wang, SJ Bowen, BA Schweitzer, ... Bioorganic & medicinal chemistry letters 21 (21), 6545-6553, 2011 | 39 | 2011 |
Anna VulpettiCADD, NovartisVerified email at novartis.com
