Jose M.P. Freije
Jose M.P. Freije
Professor, Biochemistry and Molecular Biology, Univ. Oviedo
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Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia
XS Puente, M Pinyol, V Quesada, L Conde, GR Ordóñez, N Villamor, ...
Nature 475 (7354), 101-105, 2011
Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia
V Quesada, L Conde, N Villamor, GR Ordóñez, P Jares, L Bassaganyas, ...
Nature genetics 44 (1), 47-52, 2012
Molecular cloning and expression of collagenase-3, a novel human matrix metalloproteinase produced by breast carcinomas
JM Freije, I Diez-Itza, M Balbín, LM Sánchez, R Blasco, J Tolivia, ...
Journal of Biological Chemistry 269 (24), 16766-16773, 1994
Defective prelamin A processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase–deficient mice
AM Pendás, Z Zhou, J Cadiñanos, JMP Freije, J Wang, K Hultenby, ...
Nature genetics 31 (1), 94-99, 2002
Metabolic control of longevity
C López-Otín, L Galluzzi, JMP Freije, F Madeo, G Kroemer
Cell 166 (4), 802-821, 2016
Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation
I Varela, J Cadinanos, AM Pendás, A Gutiérrez-Fernández, AR Folgueras, ...
Nature 437 (7058), 564-568, 2005
Deubiquitinases in cancer: new functions and therapeutic options
JM Fraile, V Quesada, D Rodríguez, JMP Freije, C López-Otín
Oncogene 31 (19), 2373-2388, 2012
Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging
I Varela, S Pereira, AP Ugalde, CL Navarro, MF Suarez, P Cau, ...
Nature medicine 14 (7), 767-772, 2008
Splicing-directed therapy in a new mouse model of human accelerated aging
FG Osorio, CL Navarro, J Cadiñanos, IC López-Mejía, PM Quirós, ...
Science translational medicine 3 (106), 106ra107-106ra107, 2011
Chromosomal mapping and nucleotide sequence of two tandem repeats of Atlantic salmon 5S rDNA
AM Pendás, P Moran, JP Freije, E Garcia-Vazquez
Cytogenetic and Genome Research 67 (1), 31-36, 1994
Identification and characterization of human MT5-MMP, a new membrane-bound activator of progelatinase a overexpressed in brain tumors
E Llano, AM Pendás, JP Freije, A Nakano, V Knäuper, G Murphy, ...
Cancer research 59 (11), 2570-2576, 1999
Loss of ZMPSTE24 (FACE-1) causes autosomal recessive restrictive dermopathy and accumulation of Lamin A precursors
CL Navarro, J Cadinanos, AD Sandre-Giovannoli, R Bernard, S Courrier, ...
Human molecular genetics 14 (11), 1503-1513, 2005
Differential effects of transforming growth factor-β on the expression of collagenase-1 and collagenase-3 in human fibroblasts
JA Urı́a, MG Jiménez, M Balbı́n, JMP Freije, C López-Otı́n
Journal of Biological Chemistry 273 (16), 9769-9777, 1998
Membrane type 4 matrix metalloproteinase (MMP17) has tumor necrosis factor-α convertase activity but does not activate pro-MMP2
WR English, XS Puente, JMP Freije, V Knäuper, A Amour, ...
Journal of Biological Chemistry 275 (19), 14046-14055, 2000
A serine phosphorylation of Nm23, and not its nucleoside diphosphate kinase activity, correlates with suppression of tumor metastatic potential.
NJ MacDonald, A De La Rosa, MA Benedict, JM Freije, H Krutsch, ...
Journal of Biological Chemistry 268 (34), 25780-25789, 1993
Nuclear lamina defects cause ATM-dependent NF-κB activation and link accelerated aging to a systemic inflammatory response
FG Osorio, C Bárcena, C Soria-Valles, AJ Ramsay, F de Carlos, J Cobo, ...
Genes & development 26 (20), 2311-2324, 2012
Aging and chronic DNA damage response activate a regulatory pathway involving miR‐29 and p53
AP Ugalde, AJ Ramsay, J De La Rosa, I Varela, G Mariño, J Cadiñanos, ...
The EMBO journal 30 (11), 2219-2232, 2011
Matrix metalloproteinases and tumor progression
JMP Freije, M Balbín, AM Pendás, LM Sánchez, XS Puente, C López-Otín
New Trends in Cancer for the 21st Century, 91-107, 2003
Structure and expression in breast tumors of human TIMP-3, a new member of the metalloproteinase inhibitor family
JA Uría, AA Ferrando, G Velasco, JMP Freije, C López-Otín
Cancer Research 54 (8), 2091-2094, 1994
Exome sequencing and functional analysis identifies BANF1 mutation as the cause of a hereditary progeroid syndrome
XS Puente, V Quesada, FG Osorio, R Cabanillas, J Cadiñanos, JM Fraile, ...
The American Journal of Human Genetics 88 (5), 650-656, 2011
El sistema no puede realizar la operación en estos momentos. Inténtalo de nuevo más tarde.
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