| PIKfyve, a mammalian ortholog of yeast Fab1p lipid kinase, synthesizes 5-phosphoinositides: effect of insulin D Sbrissa, OC Ikonomov, A Shisheva Journal of Biological Chemistry 274 (31), 21589-21597, 1999 | 307 | 1999 |
| Mammalian cell morphology and endocytic membrane homeostasis require enzymatically active phosphoinositide 5-kinase PIKfyve OC Ikonomov, D Sbrissa, A Shisheva Journal of Biological Chemistry 276 (28), 26141-26147, 2001 | 274 | 2001 |
| Core protein machinery for mammalian phosphatidylinositol 3, 5-bisphosphate synthesis and turnover that regulates the progression of endosomal transport: novel Sac phosphatase … D Sbrissa, OC Ikonomov, Z Fu, T Ijuin, J Gruenberg, T Takenawa, ... Journal of Biological Chemistry 282 (33), 23878-23891, 2007 | 208 | 2007 |
| The phosphoinositide kinase PIKfyve is vital in early embryonic development: preimplantation lethality of PIKfyve−/− embryos but normality of PIKfyve+/− mice OC Ikonomov, D Sbrissa, K Delvecchio, Y Xie, JP Jin, D Rappolee, ... Journal of Biological Chemistry 286 (15), 13404-13413, 2011 | 157 | 2011 |
| Phosphatidylinositol 5-phosphate biosynthesis is linked to PIKfyve and is involved in osmotic response pathway in mammalian cells D Sbrissa, OC Ikonomov, R Deeb, A Shisheva Journal of Biological Chemistry 277 (49), 47276-47284, 2002 | 156 | 2002 |
| Functional dissection of lipid and protein kinase signals of PIKfyve reveals the role of PtdIns 3, 5-P2 production for endomembrane integrity OC Ikonomov, D Sbrissa, K Mlak, M Kanzaki, J Pessin, A Shisheva Journal of Biological Chemistry 277 (11), 9206-9211, 2002 | 143 | 2002 |
| Phosphatidylinositol 3-phosphate-interacting domains in PIKfyve: binding specificity and role in PIKfyve endomembrane localization D Sbrissa, OC Ikonomov, A Shisheva Journal of Biological Chemistry 277 (8), 6073-6079, 2002 | 139 | 2002 |
| Localized PtdIns 3,5-P2 synthesis to regulate early endosome dynamics and fusion OC Ikonomov, D Sbrissa, A Shisheva American Journal of Physiology-Cell Physiology 291 (2), C393-C404, 2006 | 130 | 2006 |
| PIKfyve controls fluid phase endocytosis but not recycling/degradation of endocytosed receptors or sorting of procathepsin D by regulating multivesicular body morphogenesis OC Ikonomov, D Sbrissa, M Foti, JL Carpentier, A Shisheva Molecular biology of the cell 14 (11), 4581-4591, 2003 | 129 | 2003 |
| Cloning, Characterization, and Expression of a Novel Zn2+-Binding FYVE Finger-Containing Phosphoinositide Kinase in Insulin-Sensitive Cells A Shisheva, D Sbrissa, O Ikonomov Molecular and Cellular Biology 19 (1), 623-634, 1999 | 129 | 1999 |
| Role for a novel signaling intermediate, phosphatidylinositol 5-phosphate, in insulin-regulated F-actin stress fiber breakdown and GLUT4 translocation D Sbrissa, OC Ikonomov, J Strakova, A Shisheva Endocrinology 145 (11), 4853-4865, 2004 | 124 | 2004 |
| Molecular mechanisms underlying mood stabilization in manic-depressive illness: the phenotype challenge OC Ikonomov, HK Manji American Journal of Psychiatry 156 (10), 1506-1514, 1999 | 123 | 1999 |
| ArPIKfyve homomeric and heteromeric interactions scaffold PIKfyve and Sac3 in a complex to promote PIKfyve activity and functionality D Sbrissa, OC Ikonomov, H Fenner, A Shisheva Journal of molecular biology 384 (4), 766-779, 2008 | 96 | 2008 |
| Requirement for PIKfyve enzymatic activity in acute and long-term insulin cellular effects OC Ikonomov, D Sbrissa, K Mlak, A Shisheva Endocrinology 143 (12), 4742-4754, 2002 | 94 | 2002 |
| Localization and insulin-regulated relocation of phosphoinositide 5-kinase PIKfyve in 3T3-L1 adipocytes A Shisheva, B Rusin, OC Ikonomov, C DeMarco, D Sbrissa Journal of Biological Chemistry 276 (15), 11859-11869, 2001 | 91 | 2001 |
| Functional dissociation between PIKfyve-synthesized PtdIns5P and PtdIns(3,5)P2 by means of the PIKfyve inhibitor YM201636 D Sbrissa, OC Ikonomov, C Filios, K Delvecchio, A Shisheva American Journal of Physiology-Cell Physiology 303 (4), C436-C446, 2012 | 87 | 2012 |
| Active PIKfyve associates with and promotes the membrane attachment of the late endosome-to-trans-Golgi network transport factor Rab9 effector p40 OC Ikonomov, D Sbrissa, K Mlak, R Deeb, J Fligger, A Soans, RL Finley, ... Journal of Biological Chemistry 278 (51), 50863-50871, 2003 | 78 | 2003 |
| PIKfyve-ArPIKfyve-Sac3 Core Complex OC Ikonomov, D Sbrissa, H Fenner, A Shisheva Journal of biological chemistry 284 (51), 35794-35806, 2009 | 76 | 2009 |
| A Mammalian Ortholog of Saccharomyces cerevisiae Vac14 That Associates with and Up-Regulates PIKfyve Phosphoinositide 5-Kinase Activity D Sbrissa, OC Ikonomov, J Strakova, R Dondapati, K Mlak, R Deeb, ... Molecular and Cellular Biology 24 (23), 10437-10447, 2004 | 76 | 2004 |
| PIKfyve lipid kinase is a protein Kinase: downregulation of 5 ‘-phosphoinositide product formation by autophosphorylation D Sbrissa, OC Ikonomov, A Shisheva Biochemistry 39 (51), 15980-15989, 2000 | 75 | 2000 |
