| Aldose reductase enzyme and its implication to major health problems of the 21st century P Alexiou, K Pegklidou, M Chatzopoulou, I Nicolaou, VJ Demopoulos Current medicinal chemistry 16 (6), 734-752, 2009 | 268 | 2009 |
| RAGE: a multi-ligand receptor unveiling novel insights in health and disease P Alexiou, M Chatzopoulou, K Pegklidou, VJ Demopoulos Current medicinal chemistry 17 (21), 2232-2252, 2010 | 176 | 2010 |
| Isomeric benzoylpyrroleacetic acids: some structural aspects for aldose reductase inhibitory and anti-inflammatory activities VJ Demopoulos, E Rekka Journal of Pharmaceutical Sciences 84 (1), 79-82, 1995 | 109 | 1995 |
| Design and synthesis of novel series of pyrrole based chemotypes and their evaluation as selective aldose reductase inhibitors. A case of bioisosterism between a carboxylic … K Pegklidou, C Koukoulitsa, I Nicolaou, VJ Demopoulos Bioorganic & Medicinal Chemistry 18 (6), 2107-2114, 2010 | 87 | 2010 |
| Carboxymethylated pyridoindole antioxidants as aldose reductase inhibitors: Synthesis, activity, partitioning, and molecular modeling M Stefek, V Snirc, PO Djoubissie, M Majekova, V Demopoulos, L Rackova, ... Bioorganic & medicinal chemistry 16 (9), 4908-4920, 2008 | 74 | 2008 |
| Substituted pyrrol-1-ylacetic acids that combine aldose reductase enzyme inhibitory activity and ability to prevent the nonenzymatic irreversible modification of proteins from … I Nicolaou, VJ Demopoulos Journal of medicinal chemistry 46 (3), 417-426, 2003 | 74 | 2003 |
| A diverse series of substituted benzenesulfonamides as aldose reductase inhibitors with antioxidant activity: design, synthesis, and in vitro activity P Alexiou, VJ Demopoulos Journal of medicinal chemistry 53 (21), 7756-7766, 2010 | 70 | 2010 |
| Proposed dopaminergic pharmacophore of lergotrile, pergolide, and related ergot alkaloid derivatives JG Cannon, BJ Demopoulos, JP Long, JR Flynn, FM Sharabi Journal of Medicinal Chemistry 24 (3), 238-240, 1981 | 67 | 1981 |
| The aldose reductase inhibitory capacity of Sorbus domestica fruit extracts depends on their phenolic content and may be useful for the control of diabetic complications A Termentzi, P Alexiou, VJ Demopoulos, E Kokkalou Die Pharmazie-An International Journal of Pharmaceutical Sciences 63 (9 …, 2008 | 62 | 2008 |
| Pyrrole chemistry. XXVI. A synthesis of porphobilinogen from pyrrole BJ Demopoulos, HJ Anderson, CE Loader, K Faber Canadian journal of chemistry 61 (10), 2415-2422, 1983 | 54 | 1983 |
| [1-(3, 5-Difluoro-4-hydroxyphenyl)-1 H-pyrrol-3-yl] phenylmethanone as a bioisostere of a carboxylic acid aldose reductase inhibitor I Nicolaou, C Zika, VJ Demopoulos Journal of medicinal chemistry 47 (10), 2706-2709, 2004 | 53 | 2004 |
| Novel aldose reductase inhibitors: a patent survey (2006–present) M Chatzopoulou, P Alexiou, E Kotsampasakou, VJ Demopoulos Expert opinion on therapeutic patents 22 (11), 1303-1323, 2012 | 51 | 2012 |
| Evaluation of aldose reductase inhibition and docking studies of some secondary metabolites, isolated from Origanum vulgare L. ssp. hirtum C Koukoulitsa, C Zika, GD Geromichalos, VJ Demopoulos, H Skaltsa Bioorganic & medicinal chemistry 14 (5), 1653-1659, 2006 | 47 | 2006 |
| Development of aldose reductase inhibitors for the treatment of inflammatory disorders M Chatzopoulou, K Pegklidou, N Papastavrou, VJ Demopoulos Expert opinion on drug discovery 8 (11), 1365-1380, 2013 | 46 | 2013 |
| Toward the development of innovative bifunctional agents to induce differentiation and to promote apoptosis in leukemia: clinical candidates and perspectives IS Vizirianakis, M Chatzopoulou, ID Bonovolias, I Nicolaou, ... Journal of medicinal chemistry 53 (19), 6779-6810, 2010 | 35 | 2010 |
| Structure–activity relations on [1-(3, 5-difluoro-4-hydroxyphenyl)-1H-pyrrol-3-yl] phenylmethanone. The effect of methoxy substitution on aldose reductase inhibitory activity … M Chatzopoulou, E Mamadou, M Juskova, C Koukoulitsa, I Nicolaou, ... Bioorganic & medicinal chemistry 19 (4), 1426-1433, 2011 | 31 | 2011 |
| Permeability characteristics of novel aldose reductase inhibitors using rat jejunum in vitro K Šturm, L Levstik, VJ Demopoulos, A Kristl European journal of pharmaceutical sciences 28 (1-2), 128-133, 2006 | 28 | 2006 |
| Design and synthesis of N-(3, 5-difluoro-4-hydroxyphenyl) benzenesulfonamides as aldose reductase inhibitors P Alexiou, I Nicolaou, M Stefek, A Kristl, VJ Demopoulos Bioorganic & medicinal chemistry 16 (7), 3926-3932, 2008 | 26 | 2008 |
| Pyrrolylbenzothiazole derivatives as aldose reductase inhibitors N Zaher, I Nicolaou, VJ Demopoulos Journal of enzyme inhibition and medicinal chemistry 17 (2), 131-135, 2002 | 26 | 2002 |
| A combinatorial access to 1, 5-benzodiazepine derivatives and their evaluation for aldose reductase inhibition M Pozarentzi, J Stephanidou-Stephanatou, CA Tsoleridis, C Zika, ... Tetrahedron 65 (36), 7741-7751, 2009 | 25 | 2009 |
