| Structure of acid-sensing ion channel 1 at 1.9 Å resolution and low pH J Jasti, H Furukawa, EB Gonzales, E Gouaux Nature 449 (7160), 316-323, 2007 | 1215 | 2007 |
| Discovery and Preclinical Profiling of 3-[4-(Morpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile (PF-06447475), a Highly Potent, Selective, Brain Penetrant … JL Henderson, BL Kormos, MM Hayward, KJ Coffman, J Jasti, ... Journal of medicinal chemistry 58 (1), 419-432, 2015 | 183 | 2015 |
| First structural evidence of a specific inhibition of phospholipase A2 by α-tocopherol (vitamin E) and its implications in inflammation: Crystal structure of the complex formed … V Chandra, J Jasti, P Kaur, C Betzel, A Srinivasan, TP Singh Journal of molecular biology 320 (2), 215-222, 2002 | 161 | 2002 |
| Structural Basis of Phospholipase A2 Inhibition for the Synthesis of Prostaglandins by the Plant Alkaloid Aristolochic Acid from a 1.7 Å Crystal Structure, V Chandra, J Jasti, P Kaur, A Srinivasan, C Betzel, TP Singh Biochemistry 41 (36), 10914-10919, 2002 | 83 | 2002 |
| Crystal structure of a complex formed between a snake venom phospholipase A2 and a potent peptide inhibitor Phe-Leu-Ser-Tyr-Lys at 1.8 Å resolution V Chandra, J Jasti, P Kaur, S Dey, M Perbandt, A Srinivasan, C Betzel, ... Journal of Biological Chemistry 277 (43), 41079-41085, 2002 | 50 | 2002 |
| Discovery of PF-06835919: a potent inhibitor of ketohexokinase (KHK) for the treatment of metabolic disorders driven by the overconsumption of fructose K Futatsugi, AC Smith, M Tu, B Raymer, K Ahn, SB Coffey, MS Dowling, ... Journal of Medicinal Chemistry 63 (22), 13546-13560, 2020 | 49 | 2020 |
| Design of specific peptide inhibitors of phospholipase A2: structure of a complex formed between Russell's viper phospholipase A2 and a designed peptide Leu-Ala-Ile-Tyr-Ser (LAIYS) V Chandra, J Jasti, P Kaur, S Dey, A Srinivasan, C Betzel, TP Singh Acta Crystallographica Section D: Biological Crystallography 58 (10), 1813-1819, 2002 | 46 | 2002 |
| PF-07059013: a noncovalent modulator of hemoglobin for treatment of sickle cell disease A Gopalsamy, AE Aulabaugh, A Barakat, KC Beaumont, S Cabral, ... Journal of Medicinal Chemistry 64 (1), 326-342, 2020 | 33 | 2020 |
| Crystal structure of echicetin from Echis carinatus (Indian saw-scaled viper) at 2.4 Å resolution J Jasti, M Paramasivam, A Srinivasan, TP Singh Journal of molecular biology 335 (1), 167-176, 2004 | 32 | 2004 |
| Regulation of catalytic function by molecular association: structure of phospholipase A2 from Daboia russelli pulchella (DPLA2) at 1.9 Å resolution V Chandra, P Kaur, J Jasti, C Betzel, TP Singh Acta Crystallographica Section D: Biological Crystallography 57 (12), 1793-1798, 2001 | 32 | 2001 |
| Structure of an acidic phospholipase A2 from Indian saw-scaled viper (Echis carinatus) at 2.6 Å resolution reveals a novel intermolecular interaction J Jasti, M Paramasivam, A Srinivasan, TP Singh Acta Crystallographica Section D: Biological Crystallography 60 (1), 66-72, 2004 | 30 | 2004 |
| Crystal structure of a proteolytically generated functional monoferric C-lobe of bovine lactoferrin at 1.9 Å resolution S Sharma, J Jasti, J Kumar, AK Mohanty, TP Singh Journal of molecular biology 331 (2), 485-496, 2003 | 27 | 2003 |
| Crystal structure of a heterodimer of phospholipase A2 from Naja naja sagittifera at 2.3 Å resolution reveals the presence of a new PLA2‐like protein with a novel cys 32–Cys 49 … T Jabeen, N Singh, RK Singh, J Jasti, S Sharma, P Kaur, A Srinivasan, ... Proteins: Structure, Function, and Bioinformatics 62 (2), 329-337, 2006 | 21 | 2006 |
| Rational approach to highly potent and selective apoptosis signal-regulating kinase 1 (ASK1) inhibitors F Lovering, P Morgan, C Allais, A Aulabaugh, J Brodfuehrer, J Chang, ... European Journal of Medicinal Chemistry 145, 606-621, 2018 | 19 | 2018 |
| Crystal structure of the complex formed between a group I Phospholipase A2 and a naturally occurring fatty acid at 2.7 Å resolution G Singh, J Jasti, K Saravanan, S Sharma, P Kaur, A Srinivasan, TP Singh Protein science 14 (2), 395-400, 2005 | 18 | 2005 |
| PF‐07059013: A non‐covalent hemoglobin modulator favorably impacts disease state in a mouse model of sickle cell disease KM Knee, R Jasuja, A Barakat, D Rao, Z Wenzel, J Jasti, J Novak, ... American Journal of Hematology 96 (8), E272, 2021 | 6 | 2021 |
| Expression, purification, crystallization and preliminary X-ray diffraction studies of recombinant class B non-specific acid phosphatase of Salmonella typhimurium RD Makde, V Kumar, GD Gupta, J Jasti, TP Singh, SK Mahajan Acta Crystallographica Section D: Biological Crystallography 59 (10), 1849-1852, 2003 | 5 | 2003 |
| Chemical compounds A Gopalsamy, AV Narayanan, A Casimiro-Garcia, C Choi, D Hepworth, ... US Patent 11,014,908, 2021 | 2 | 2021 |
| Chemical Compounds A Gopalsamy, S Cabral, AC Garcia, MZ Chen, C Choi, RL Dow, ... US Patent App. 18/322,844, 2023 | | 2023 |
| Chemical compounds A Gopalsamy, S Cabral, A Casimiro-Garcia, MZ Chen, C Choi, RL Dow, ... US Patent 11,702,405, 2023 | | 2023 |
