Directed evolution mimics allosteric activation by stepwise tuning of the conformational ensemble AR Buller, P Van Roye, JKB Cahn, RA Scheele, M Herger, FH Arnold Journal of the American Chemical Society 140 (23), 7256-7266, 2018 | 90 | 2018 |
Engineered biosynthesis of β‐alkyl tryptophan analogues CE Boville, RA Scheele, P Koch, S Brinkmann‐Chen, AR Buller, ... Angewandte Chemie 130 (45), 14980-14984, 2018 | 60 | 2018 |
A Hydroxyquinoline‐Based Unnatural Amino Acid for the Design of Novel Artificial Metalloenzymes I Drienovská, RA Scheele, C Gutiérrez de Souza, G Roelfes ChemBioChem 21 (21), 3077-3081, 2020 | 22 | 2020 |
Biocatalytic synthesis of α-amino ketones SW Chun, ARH Narayan Synlett 30 (11), 1269-1274, 2019 | 21 | 2019 |
Droplet-based screening of phosphate transfer catalysis reveals how epistasis shapes MAP kinase interactions with substrates RA Scheele, LH Lindenburg, M Petek, M Schober, KN Dalby, F Hollfelder Nature Communications 13 (1), 844, 2022 | 11 | 2022 |
Beta-substituted non-canonical amino acids CE Boville, S Brinkmann-Chen, AR Buller, DK Romney, CK Prier, P Koch, ... US Patent 10,612,056, 2020 | 4 | 2020 |
Ultrahigh Throughput Evolution of Tryptophan Synthase in Droplets via an Aptamer Sensor RA Scheele, Y Weber, FEH Nintzel, M Herger, TS Kaminski, F Hollfelder ACS catalysis 14, 6259-6271, 2024 | 1 | 2024 |
Methods and enzyme catalysts for the synthesis of non-canonical amino acids CE Boville, S Brinkmann-Chen, AR Buller, DK Romney, CK Prier, P Koch, ... US Patent App. 17/556,555, 2022 | | 2022 |
Widespread positive epistasis shapes molecular recognition in a human kinase pair M Petek, R Scheele, F Hollfelder FEBS OPEN BIO 12, 37-37, 2022 | | 2022 |
Methods and enzyme catalysts for the synthesis of non-canonical amino acids CE Boville, S Brinkmann-Chen, AR Buller, DK Romney, CK Prier, P Koch, ... US Patent 11,279,959, 2022 | | 2022 |
Strategies to Roam Enzymatic Fitness Landscapes in Ultrahigh-Throughput R Scheele | | 2022 |
Engineering a biocatalytic platform to produce β-branched tryptophan derivatives RA Scheele Faculty of Science and Engineering, 2017 | | 2017 |
Screening of new or improved enzymes by microfluidic chips RA Scheele Faculty of Science and Engineering, 2016 | | 2016 |
Investigating the catalytic potential of a 8-hydroxyquinoline based artificial metalloenzyme RA Scheele Faculty of Science and Engineering, 2016 | | 2016 |
Increasing oxidation of 5-formyl-2-furancarboxylic acid in 5-hydroxymethylfurfural oxidase RA Scheele Faculty of Science and Engineering, 2014 | | 2014 |
Insights into the mysterious substrate specificity of lytic polysaccharide monooxygenases RA Scheele Faculty of Science and Engineering, 2014 | | 2014 |
Angewandte CE Boville, RA Scheele, P Koch, S Brinkmann-Chen, AR Buller, ... | | |