| Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma PK Mazur, A Herner, SS Mello, M Wirth, S Hausmann, FJ Sánchez-Rivera, ... Nature medicine 21 (10), 1163-1171, 2015 | 374 | 2015 |
| Microenvironmental determinants of pancreatic cancer E Hessmann, SM Buchholz, IE Demir, SK Singh, TM Gress, V Ellenrieder, ... Physiological reviews, 2020 | 208 | 2020 |
| Fibroblast drug scavenging increases intratumoural gemcitabine accumulation in murine pancreas cancer E Hessmann, MS Patzak, L Klein, N Chen, V Kari, I Ramu, TE Bapiro, ... Gut 67 (3), 497-507, 2018 | 207 | 2018 |
| Loss of ATM accelerates pancreatic cancer formation and epithelial–mesenchymal transition R Russell, L Perkhofer, S Liebau, Q Lin, A Lechel, FM Feld, E Hessmann, ... Nature communications 6 (1), 7677, 2015 | 149 | 2015 |
| Chemoradiotherapy resistance in colorectal cancer cells is mediated by Wnt/β-catenin signaling G Emons, M Spitzner, S Reineke, J Möller, N Auslander, F Kramer, Y Hu, ... Molecular Cancer Research 15 (11), 1481-1490, 2017 | 130 | 2017 |
| Inflammation-Induced NFATc1–STAT3 Transcription Complex Promotes Pancreatic Cancer Initiation by KrasG12D S Baumgart, NM Chen, JT Siveke, A König, JS Zhang, SK Singh, E Wolf, ... Cancer discovery 4 (6), 688-701, 2014 | 130 | 2014 |
| MYC in pancreatic cancer: novel mechanistic insights and their translation into therapeutic strategies E Hessmann, G Schneider, V Ellenrieder, JT Siveke Oncogene 35 (13), 1609-1618, 2016 | 126 | 2016 |
| Epigenetic treatment of pancreatic cancer: is there a therapeutic perspective on the horizon? E Hessmann, SA Johnsen, JT Siveke, V Ellenrieder Gut 66 (1), 168-179, 2017 | 122 | 2017 |
| Antithetical NFAT c1–Sox2 and p53–miR200 signaling networks govern pancreatic cancer cell plasticity SK Singh, NM Chen, E Hessmann, J Siveke, M Lahmann, G Singh, ... The EMBO journal 34 (4), 517-530, 2015 | 111 | 2015 |
| ATM deficiency generating genomic instability sensitizes pancreatic ductal adenocarcinoma cells to therapy-induced DNA damage L Perkhofer, A Schmitt, MC Romero Carrasco, M Ihle, S Hampp, ... Cancer research 77 (20), 5576-5590, 2017 | 103 | 2017 |
| NFATc1 links EGFR signaling to induction of Sox9 transcription and acinar–ductal transdifferentiation in the pancreas NM Chen, G Singh, A Koenig, GY Liou, P Storz, JS Zhang, L Regul, ... Gastroenterology 148 (5), 1024-1034. e9, 2015 | 100 | 2015 |
| Histone deacetylase class-I inhibition promotes epithelial gene expression in pancreatic cancer cells in a BRD4-and MYC-dependent manner VK Mishra, F Wegwitz, RL Kosinsky, M Sen, R Baumgartner, T Wulff, ... Nucleic acids research 45 (11), 6334-6349, 2017 | 82 | 2017 |
| EZH2 Regulates Pancreatic Cancer Subtype Identity and Tumor Progression via Transcriptional Repression of GATA6 S Patil, B Steuber, W Kopp, V Kari, L Urbach, X Wang, S Küffer, ... Cancer research 80 (21), 4620-4632, 2020 | 68 | 2020 |
| Synergistic targeting and resistance to PARP inhibition in DNA damage repair-deficient pancreatic cancer J Gout, L Perkhofer, M Morawe, F Arnold, M Ihle, S Biber, S Lange, ... Gut 70 (4), 743-760, 2021 | 61 | 2021 |
| ARID1A facilitates KRAS signaling-regulated enhancer activity in an AP1-dependent manner in colorectal cancer cells M Sen, X Wang, FH Hamdan, J Rapp, J Eggert, RL Kosinsky, F Wegwitz, ... Clinical epigenetics 11, 1-16, 2019 | 54 | 2019 |
| Context-dependent epigenetic regulation of nuclear factor of activated T cells 1 in pancreatic plasticity NM Chen, A Neesse, ML Dyck, B Steuber, AO Koenig, ... Gastroenterology 152 (6), 1507-1520. e15, 2017 | 54 | 2017 |
| NFATc1 as a therapeutic target in FLT3-ITD-positive AML SK Metzelder, C Michel, M von Bonin, M Rehberger, E Hessmann, ... Leukemia 29 (7), 1470-1477, 2015 | 50 | 2015 |
| NFATc4 regulates Sox9 gene expression in acinar cell plasticity and pancreatic cancer initiation E Hessmann, JS Zhang, NM Chen, M Hasselluhn, GY Liou, P Storz, ... Stem cells international 2016, 2016 | 45 | 2016 |
| GSK-3β governs inflammation-induced NFATc2 signaling hubs to promote pancreatic cancer progression S Baumgart, NM Chen, JS Zhang, DD Billadeau, IN Gaisina, ... Molecular cancer therapeutics 15 (3), 491-502, 2016 | 45 | 2016 |
| Depletion of macrophages improves therapeutic response to gemcitabine in murine pancreas cancer SM Buchholz, RG Goetze, SK Singh, C Ammer-Herrmenau, FM Richards, ... Cancers 12 (7), 1978, 2020 | 33 | 2020 |
