Programmable deletion, replacement, integration and inversion of large DNA sequences with twin prime editing AV Anzalone*, XD Gao* (equal contribution), CJ Podracky*, AT Nelson, ... Nature biotechnology 40 (5), 731-740, 2022 | 306 | 2022 |
Cell type-restricted activity of hnRNPM promotes breast cancer metastasis via regulating alternative splicing Y Xu, XD Gao, JH Lee, H Huang, H Tan, J Ahn, LM Reinke, ME Peter, ... Genes & Development, 1191-1203, 2014 | 228 | 2014 |
CD44 splice isoform switching determines breast cancer stem cell state H Zhang, RL Brown, Y Wei, P Zhao, S Liu, X Liu, Y Deng, X Hu, J Zhang, ... Genes & Development 33 (3-4), 166-179, 2019 | 168 | 2019 |
NmeCas9 is an intrinsically high-fidelity genome-editing platform N Amrani*, XD Gao* (equal contribution), P Liu, A Edraki, A Mir, ... Genome Biology 19 (1), 214, 2018 | 130 | 2018 |
C-BERST: defining subnuclear proteomic landscapes at genomic elements with dCas9–APEX2 XD Gao, LC Tu, A Mir, T Rodriguez, Y Ding, J Leszyk, J Dekker, ... Nature methods 15 (6), 433-436, 2018 | 119 | 2018 |
Potent Cas9 inhibition in bacterial and human cells by AcrIIC4 and AcrIIC5 Anti-CRISPR proteins J Lee, A Mir, A Edraki, B Garcia, N Amrani, HE Lou, I Gainetdinov, ... MBio 9 (6), e02321-18, 2018 | 92 | 2018 |
Coregulation of alternative splicing by hnRNPM and ESRP1 during EMT SE Harvey, Y Xu, X Lin, XD Gao, Y Qiu, J Ahn, X Xiao, C Cheng Rna 24 (10), 1326-1338, 2018 | 65 | 2018 |
In vivo base editing rescues cone photoreceptors in a mouse model of early-onset inherited retinal degeneration EH Choi, S Suh, AT Foik, H Leinonen, GA Newby, XD Gao, S Banskota, ... Nature communications 13 (1), 1830, 2022 | 44 | 2022 |
Phage-assisted evolution and protein engineering yield compact, efficient prime editors JL Doman, S Pandey, ME Neugebauer, M An, JR Davis, PB Randolph, ... Cell 186 (18), 3983-4002. e26, 2023 | 41 | 2023 |
Adenine Base Editing In Vivo with a Single Adeno-Associated Virus Vector H Zhang, N Bamidele, P Liu, O Ojelabi, XD Gao, T Rodriguez, H Cheng, ... GEN biotechnology 1 (3), 285-299, 2022 | 30 | 2022 |
Adapting dCas9-APEX2 for subnuclear proteomic profiling XD Gao, TC Rodríguez, EJ Sontheimer Methods in Enzymology 616, 365-383, 2019 | 7 | 2019 |
Prime editing: current advances and therapeutic opportunities in human diseases Y Fu, X He, XD Gao, F Li, S Ge, Z Yang, X Fan Science Bulletin, 2023 | 4 | 2023 |
Methods and compositions for simultaneous editing of both strands of a target double-stranded nucleotide sequence David R Liu, Andrew Vito Anzalone, Jonathan Ma Levy, Xin Gao, Christopher J ... US Patent App. 18/053,269, 2023 | 2* | 2023 |
Programmable Deletion, Replacement, Integration and Inversion of Large DNA Sequences with Twin Prime Editing and Site-Specific Recombinases AV Anzalone, XD Gao, CP Podracky, AT Nelson, LW Koblan, A Raguram, ... MOLECULAR THERAPY 30 (4), 392-393, 2022 | 1 | 2022 |
Twin prime editing mediated exon skipping/reinsertion for restored collagen VII expression in recessive dystrophic epidermolysis bullosa BJ Steinbeck, XD Gao, AN McElroy, S Pandey, JL Doman, MJ Riddle, ... Journal of Investigative Dermatology, 2024 | | 2024 |
Prime editing DR Liu, AV Anzalone, JM Levy, X Gao, CJ Podracky nature biotechnology 42 (570), 570, 2024 | | 2024 |
Development of Cytosine and Adenine Base Editors with an Expanded Targeting Range P Liu, K Luk, K Ponnienselvan, XD Gao, A Edraki, EJ Sontheimer, ... MOLECULAR THERAPY 28 (4), 105-105, 2020 | | 2020 |
Mapping subnuclear proteomes onto genome architecture via C-BERST EJ Sontheimer, XD Gao, LC Tu, A Mir, T Rodriguez, Y Ding, J Leszyk, ... | | 2018 |
C-BERST: Defining subnuclear proteomic landscapes at genomic elements with dCas9-APEX2 [preprint] XD Gao, LC Tu, A Mir, YH Ding, JD Leszyk, J Dekker, SA Shaffer, LJ Zhu, ... | | 2018 |