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Amit Luthra
Amit Luthra
Principal Scientist
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Year
Stage‐specific global alterations in the transcriptomes of L yme disease spirochetes during tick feeding and following mammalian host adaptation
R Iyer, MJ Caimano, A Luthra, D Axline Jr, A Corona, DA Iacobas, ...
Molecular microbiology 95 (3), 509-538, 2015
1352015
Surface Immunolabeling and Consensus Computational Framework To Identify Candidate Rare Outer Membrane Proteins of Treponema pallidum
DL Cox, A Luthra, S Dunham-Ems, DC Desrosiers, JC Salazar, ...
Infection and immunity 78 (12), 5178-5194, 2010
1312010
TP0326, a Treponema pallidum β‐barrel assembly machinery A (BamA) orthologue and rare outer membrane protein
DC Desrosiers, A Anand, A Luthra, SM Dunham‐Ems, M LeDoyt, ...
Molecular microbiology 80 (6), 1496-1515, 2011
892011
The RpoS Gatekeeper in Borrelia burgdorferi: An Invariant Regulatory Scheme That Promotes Spirochete Persistence in Reservoir Hosts and Niche Diversity
MJ Caimano, AM Groshong, A Belperron, J Mao, KL Hawley, A Luthra, ...
Frontiers in Microbiology 10, 1923, 2019
622019
TprC/D (Tp0117/131), a trimeric, pore-forming rare outer membrane protein of Treponema pallidum, has a bipartite domain structure
A Anand, A Luthra, S Dunham-Ems, MJ Caimano, C Karanian, M LeDoyt, ...
Journal of bacteriology 194 (9), 2321-2333, 2012
602012
Characterization of Rv3868, an essential hypothetical protein of the ESX-1 secretion system in Mycobacterium tuberculosis
A Luthra, A Mahmood, A Arora, R Ramachandran
Journal of biological chemistry 283 (52), 36532-36541, 2008
502008
Structural modeling and physicochemical characterization provide evidence that P66 forms a β-barrel in the Borrelia burgdorferi outer membrane
MR Kenedy, A Luthra, A Anand, JP Dunn, JD Radolf, DR Akins
Journal of bacteriology 196 (4), 859-872, 2014
412014
The transition from closed to open conformation of Treponema pallidum outer membrane-associated lipoprotein TP0453 involves membrane sensing and integration by two amphipathic …
A Luthra, G Zhu, DC Desrosiers, CH Eggers, V Mulay, A Anand, ...
Journal of Biological Chemistry 286 (48), 41656-41668, 2011
392011
The major outer sheath protein (Msp) of Treponema denticola has a bipartite domain architecture and exists as periplasmic and outer membrane-spanning conformers
A Anand, A Luthra, ME Edmond, M Ledoyt, MJ Caimano, JD Radolf
Journal of bacteriology 195 (9), 2060-2071, 2013
362013
Bipartite topology of Treponema pallidum repeat proteins C/D and I: outer membrane insertion, trimerization, and porin function require a C-terminal β-barrel domain
A Anand, M LeDoyt, C Karanian, A Luthra, M Koszelak-Rosenblum, ...
Journal of Biological Chemistry 290 (19), 12313-12331, 2015
352015
A homology model reveals novel structural features and an immunodominant surface loop/opsonic target in the Treponema pallidum BamA ortholog TP_0326
A Luthra, A Anand, KL Hawley, M LeDoyt, CJ La Vake, MJ Caimano, ...
Journal of bacteriology 197 (11), 1906-1920, 2015
322015
Structure and mechanism of a bacterial t6A biosynthesis system
A Luthra, W Swinehart, S Bayooz, P Phan, B Stec, D Iwata-Reuyl, ...
Nucleic acids research 46 (3), 1395-1411, 2018
262018
Structural characterization and modeling of the Borrelia burgdorferi hybrid histidine kinase Hk1 periplasmic sensor: A system for sensing small molecules associated with tick …
WJ Bauer, A Luthra, G Zhu, JD Radolf, MG Malkowski, MJ Caimano
Journal of structural biology 192 (1), 48-58, 2015
232015
Structural modeling of the Treponema pallidum outer membrane protein repertoire: a road map for deconvolution of syphilis pathogenesis and development of a syphilis vaccine
KL Hawley, JM Montezuma-Rusca, KN Delgado, N Singh, VN Uversky, ...
Journal of Bacteriology 203 (15), 10.1128/jb. 00082-21, 2021
222021
Conformational communication mediates the reset step in t6A biosynthesis
A Luthra, N Paranagama, W Swinehart, S Bayooz, P Phan, V Quach, ...
Nucleic acids research 47 (12), 6551-6567, 2019
212019
Evidence that immunization with TP0751, a bipartite Treponema pallidum lipoprotein with an intrinsically disordered region and lipocalin fold, fails to protect in the rabbit …
A Luthra, JM Montezuma-Rusca, CJ La Vake, M LeDoyt, KN Delgado, ...
PLoS Pathogens 16 (9), e1008871, 2020
192020
Specificity in the biosynthesis of the universal tRNA nucleoside N6-threonylcarbamoyl adenosine (t6A)—TsaD is the gatekeeper
W Swinehart, C Deutsch, KL Sarachan, A Luthra, JM Bacusmo, ...
RNA 26 (9), 1094-1103, 2020
172020
Interactions of the M. tuberculosis UsfX with the cognate sigma factor SigF and the anti-anti sigma factor RsfA
SS Malik, A Luthra, R Ramachandran
Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1794 (3), 541-553, 2009
162009
Inhibitor potency varies widely among tumor-relevant human isocitrate dehydrogenase 1 mutants
D Avellaneda Matteo, GA Wells, LA Luna, AJ Grunseth, O Zagnitko, ...
Biochemical Journal 475 (20), 3221-3238, 2018
122018
Mechanism and catalytic strategy of the prokaryotic-specific GTP cyclohydrolase-IB
N Paranagama, SA Bonnett, J Alvarez, A Luthra, B Stec, A Gustafson, ...
Biochemical Journal 474 (6), 1017-1039, 2017
122017
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