| Polyadenylation factor CPSF-73 is the pre-mRNA 3'-end-processing endonuclease CR Mandel, S Kaneko, H Zhang, D Gebauer, V Vethantham, JL Manley, ... Nature 444 (7121), 953-956, 2006 | 548 | 2006 |
| Phosphorylation of the PRC2 component Ezh2 is cell cycle-regulated and up-regulates its binding to ncRNA S Kaneko, G Li, J Son, CF Xu, R Margueron, TA Neubert, D Reinberg Genes & development 24 (23), 2615-2620, 2010 | 430 | 2010 |
| Interactions between JARID2 and noncoding RNAs regulate PRC2 recruitment to chromatin S Kaneko, R Bonasio, R Saldaña-Meyer, T Yoshida, J Son, K Nishino, ... Molecular cell 53 (2), 290-300, 2014 | 391 | 2014 |
| PRC2 binds active promoters and contacts nascent RNAs in embryonic stem cells S Kaneko, J Son, SS Shen, D Reinberg, R Bonasio Nature structural & molecular biology 20 (11), 1258-1264, 2013 | 325 | 2013 |
| Jarid2 is implicated in the initial Xist-induced targeting of PRC2 to the inactive X chromosome ST da Rocha, V Boeva, M Escamilla-Del-Arenal, K Ancelin, C Granier, ... Molecular cell 53 (2), 301-316, 2014 | 275 | 2014 |
| The multifunctional protein p54nrb/PSF recruits the exonuclease XRN2 to facilitate pre-mRNA 3′ processing and transcription termination S Kaneko, O Rozenblatt-Rosen, M Meyerson, JL Manley Genes & development 21 (14), 1779-1789, 2007 | 213 | 2007 |
| Nascent RNA interaction keeps PRC2 activity poised and in check S Kaneko, J Son, R Bonasio, SS Shen, D Reinberg Genes & development 28 (18), 1983-1988, 2014 | 206 | 2014 |
| BRCA1/BARD1 inhibition of mRNA 3′ processing involves targeted degradation of RNA polymerase II FE Kleiman, F Wu-Baer, D Fonseca, S Kaneko, R Baer, JL Manley Genes & development 19 (10), 1227-1237, 2005 | 199 | 2005 |
| Terminating the transcript: breaking up is hard to do E Rosonina, S Kaneko, JL Manley Genes & development 20 (9), 1050-1056, 2006 | 176 | 2006 |
| Identification and functional characterization of neo-poly (A) polymerase, an RNA processing enzyme overexpressed in human tumors SL Topalian, S Kaneko, MI Gonzales, GL Bond, Y Ward, JL Manley Molecular and cellular biology, 2001 | 147 | 2001 |
| The tumor suppressor Cdc73 functionally associates with CPSF and CstF 3′ mRNA processing factors O Rozenblatt-Rosen, T Nagaike, JM Francis, S Kaneko, KA Glatt, ... Proceedings of the National Academy of Sciences 106 (3), 755-760, 2009 | 145 | 2009 |
| Application of artificial intelligence technology in oncology: Towards the establishment of precision medicine R Hamamoto, K Suvarna, M Yamada, K Kobayashi, N Shinkai, M Miyake, ... Cancers 12 (12), 3532, 2020 | 136 | 2020 |
| Allosteric activation dictates PRC2 activity independent of its recruitment to chromatin CH Lee, JR Yu, S Kumar, Y Jin, G LeRoy, N Bhanu, S Kaneko, BA Garcia, ... Molecular cell 70 (3), 422-434. e6, 2018 | 122 | 2018 |
| Epigenetics analysis and integrated analysis of multiomics data, including epigenetic data, using artificial intelligence in the era of precision medicine R Hamamoto, M Komatsu, K Takasawa, K Asada, S Kaneko Biomolecules 10 (1), 62, 2019 | 92 | 2019 |
| Requirements of the RNA polymerase II C-terminal domain for reconstituting pre-mRNA 3′ cleavage K Ryan, KGK Murthy, S Kaneko, JL Manley Molecular and cellular biology 22 (6), 1684-1692, 2002 | 90 | 2002 |
| Detection of cardiac structural abnormalities in fetal ultrasound videos using deep learning M Komatsu, A Sakai, R Komatsu, R Matsuoka, S Yasutomi, K Shozu, ... Applied Sciences 11 (1), 371, 2021 | 81 | 2021 |
| Image segmentation of the ventricular septum in fetal cardiac ultrasound videos based on deep learning using time-series information A Dozen, M Komatsu, A Sakai, R Komatsu, K Shozu, H Machino, ... Biomolecules 10 (11), 1526, 2020 | 59 | 2020 |
| Towards clinical application of artificial intelligence in ultrasound imaging M Komatsu, A Sakai, A Dozen, K Shozu, S Yasutomi, H Machino, K Asada, ... Biomedicines 9 (7), 720, 2021 | 58 | 2021 |
| Predicting deep learning based multi-omics parallel integration survival subtypes in lung cancer using reverse phase protein array data S Takahashi, K Asada, K Takasawa, R Shimoyama, A Sakai, A Bolatkan, ... Biomolecules 10 (10), 1460, 2020 | 50 | 2020 |
| The mammalian RNA polymerase II C-terminal domain interacts with RNA to suppress transcription-coupled 3′ end formation S Kaneko, JL Manley Molecular cell 20 (1), 91-103, 2005 | 50 | 2005 |
Ryuji HamamotoDirector of Division of Medical AI Research and Development, NCCRIVerified email at ncc.go.jp
