| The DNA cleavage reaction of topoisomerase II: wolf in sheep's clothing JE Deweese, N Osheroff Nucleic acids research 37 (3), 738-748, 2009 | 533 | 2009 |
| A novel and unified two-metal mechanism for DNA cleavage by type II and IA topoisomerases BH Schmidt, AB Burgin, JE Deweese, N Osheroff, JM Berger Nature 465 (7298), 641-644, 2010 | 193 | 2010 |
| DNA topology and topoisomerases: teaching a “knotty” subject JE Deweese, MA Osheroff, N Osheroff Biochemistry and Molecular Biology Education 37 (1), 2-10, 2009 | 158 | 2009 |
| DNA cleavage and opening reactions of human topoisomerase IIα are regulated via Mg2+-mediated dynamic bending of gate-DNA S Lee, SR Jung, K Heo, JAW Byl, JE Deweese, N Osheroff, S Hohng Proceedings of the National Academy of Sciences 109 (8), 2925-2930, 2012 | 80 | 2012 |
| The use of divalent metal ions by type II topoisomerases JE Deweese, N Osheroff Metallomics 2 (7), 450-459, 2010 | 75 | 2010 |
| Human topoisomerase IIα uses a two-metal-ion mechanism for DNA cleavage JE Deweese, AB Burgin, N Osheroff Nucleic acids research 36 (15), 4883-4893, 2008 | 70 | 2008 |
| Etoposide quinone is a redox-dependent topoisomerase II poison DA Jacob, SL Mercer, N Osheroff, JE Deweese Biochemistry 50 (25), 5660-5667, 2011 | 64 | 2011 |
| Etoposide quinone is a covalent poison of human topoisomerase IIβ NA Smith, JAW Byl, SL Mercer, JE Deweese, N Osheroff Biochemistry 53 (19), 3229-3236, 2014 | 56 | 2014 |
| Using 3′-bridging phosphorothiolates to isolate the forward DNA cleavage reaction of human topoisomerase IIα JE Deweese, AB Burgin, N Osheroff Biochemistry 47 (13), 4129-4140, 2008 | 50 | 2008 |
| Examining the impact of antimicrobial fluoroquinolones on human DNA topoisomerase IIα and IIβ CA Fief, KG Hoang, SD Phipps, JL Wallace, JE Deweese ACS omega 4 (2), 4049-4055, 2019 | 42 | 2019 |
| Examination of the Impact of Copper(II) α-(N)-Heterocyclic Thiosemicarbazone Complexes on DNA Topoisomerase IIα JT Wilson, X Jiang, BC McGill, EC Lisic, JE Deweese Chemical research in toxicology 29 (4), 649-658, 2016 | 42 | 2016 |
| Catalytic core of human topoisomerase IIα: Insights into enzyme–DNA interactions and drug mechanism RH Lindsey Jr, MJ Pendleton, RE Ashley, SL Mercer, JE Deweese, ... Biochemistry 53 (41), 6595-6602, 2014 | 41 | 2014 |
| Metal ion interactions in the DNA cleavage/ligation active site of human topoisomerase IIα JE Deweese, FP Guengerich, AB Burgin, N Osheroff Biochemistry 48 (38), 8940-8947, 2009 | 35 | 2009 |
| Coordinating the two protomer active sites of human topoisomerase IIα: nicks as topoisomerase II poisons JE Deweese, N Osheroff Biochemistry 48 (7), 1439-1441, 2009 | 34 | 2009 |
| HU-331 is a catalytic inhibitor of topoisomerase IIα KM Regal, SL Mercer, JE Deweese Chemical research in toxicology 27 (12), 2044-2051, 2014 | 33 | 2014 |
| Cu (II) benzoylpyridine thiosemicarbazone complexes: Inhibition of human topoisomerase IIα and activity against breast cancer cells JD Conner, W Medawala, MT Stephens, WH Morris, JE Deweese, ... Open Journal of Inorganic Chemistry 6 (2), 146-154, 2016 | 31 | 2016 |
| Two-mechanism model for the interaction of etoposide quinone with topoisomerase IIα EG Gibson, MKM King, SL Mercer, JE Deweese Chemical research in toxicology 29 (9), 1541-1548, 2016 | 29 | 2016 |
| Inhibitors and poisons of mammalian type II topoisomerases MB Murphy, SL Mercer, JE Deweese Advances in molecular toxicology 11, 203-240, 2017 | 26 | 2017 |
| Etoposide catechol is an oxidizable topoisomerase II poison DA Jacob, EG Gibson, SL Mercer, JE Deweese Chemical research in toxicology 26 (8), 1156-1158, 2013 | 26 | 2013 |
| Use of divalent metal ions in the DNA cleavage reaction of human type II topoisomerases JE Deweese, AM Burch, AB Burgin, N Osheroff Biochemistry 48 (9), 1862-1869, 2009 | 26 | 2009 |
Neil OsheroffProfessor of Biochemistry, Vanderbilt University School of MedicineDirección de correo verificada de Vanderbilt.Edu
