| Targeting aberrant RAS/RAF/MEK/ERK signaling for cancer therapy U Degirmenci, M Wang, J Hu Cells 9 (1), 198, 2020 | 411 | 2020 |
| Allosteric activation of functionally asymmetric RAF kinase dimers J Hu, EC Stites, H Yu, EA Germino, HS Meharena, PJS Stork, AP Kornev, ... Cell 154 (5), 1036-1046, 2013 | 303 | 2013 |
| The MAPK and AMPK signalings: interplay and implication in targeted cancer therapy J Yuan, X Dong, J Yap, J Hu Journal of hematology & oncology 13 (1), 113, 2020 | 294 | 2020 |
| Kinases and pseudokinases: lessons from RAF AS Shaw, AP Kornev, J Hu, LG Ahuja, SS Taylor Molecular and cellular biology 34 (9), 1538-1546, 2014 | 158 | 2014 |
| Mutation that blocks ATP binding creates a pseudokinase stabilizing the scaffolding function of kinase suppressor of Ras, CRAF and BRAF J Hu, H Yu, AP Kornev, J Zhao, EL Filbert, SS Taylor, AS Shaw Proceedings of the National Academy of Sciences 108 (15), 6067-6072, 2011 | 148 | 2011 |
| Kinase regulation by hydrophobic spine assembly in cancer J Hu, LG Ahuja, HS Meharena, N Kannan, AP Kornev, SS Taylor, ... Molecular and cellular biology 35 (1), 264-276, 2015 | 104 | 2015 |
| Identification of downstream genes up-regulated by the tumor necrosis factor family member TALL-1 LG Xu, M Wu, J Hu, Z Zhai, HB Shu Journal of leukocyte biology 72 (2), 410-416, 2002 | 101 | 2002 |
| Lsc regulates marginal-zone B cell migration and adhesion and is required for the IgM T-dependent antibody response A Rubtsov, P Strauch, A DiGiacomo, J Hu, R Pelanda, RM Torres Immunity 23 (5), 527-538, 2005 | 88 | 2005 |
| Albumin-associated free fatty acids induce macropinocytosis in podocytes JJ Chung, TB Huber, M Gödel, G Jarad, B Hartleben, C Kwoh, A Keil, ... The Journal of clinical investigation 125 (6), 2307-2316, 2015 | 80 | 2015 |
| Lysine-222 succinylation reduces lysosomal degradation of lactate dehydrogenase a and is increased in gastric cancer X Li, C Zhang, T Zhao, Z Su, M Li, J Hu, J Wen, J Shen, C Wang, J Pan, ... Journal of Experimental & Clinical Cancer Research 39, 1-17, 2020 | 77 | 2020 |
| Immunoglobulin-like transcript receptors on human dermal CD14+ dendritic cells act as a CD8-antagonist to control cytotoxic T cell priming J Banchereau, S Zurawski, LA Thompson-Snipes, JP Blanck, S Clayton, ... Proceedings of the National Academy of Sciences 109 (46), 18885-18890, 2012 | 56 | 2012 |
| Activating mutations in MEK1 enhance homodimerization and promote tumorigenesis J Yuan, WH Ng, Z Tian, J Yap, M Baccarini, Z Chen, J Hu Science signaling 11 (554), eaar6795, 2018 | 52 | 2018 |
| Pseudokinases from a structural perspective SS Taylor, A Shaw, J Hu, HS Meharena, A Kornev Biochemical Society Transactions 41 (4), 981-986, 2013 | 51 | 2013 |
| The dimer-dependent catalytic activity of RAF family kinases is revealed through characterizing their oncogenic mutants J Yuan, WH Ng, PYP Lam, Y Wang, H Xia, J Yap, SP Guan, ASG Lee, ... Oncogene 37 (43), 5719-5734, 2018 | 46 | 2018 |
| Lysophosphatidic acid receptor 5 inhibits B cell antigen receptor signaling and antibody response J Hu, SK Oda, K Shotts, EE Donovan, P Strauch, LM Pujanauski, ... The Journal of Immunology 193 (1), 85-95, 2014 | 46 | 2014 |
| Mst1 kinase regulates the actin-bundling protein L-plastin to promote T cell migration X Xu, X Wang, EM Todd, ER Jaeger, JL Vella, OL Mooren, Y Feng, J Hu, ... The Journal of Immunology 197 (5), 1683-1691, 2016 | 34 | 2016 |
| Iron homeostasis determines fate of human pluripotent stem cells via glycerophospholipids-epigenetic circuit Z Han, Y Yu, J Xu, Z Bao, Z Xu, J Hu, M Yu, D Bamba, W Ma, F Ding, ... Stem Cells 37 (4), 489-503, 2019 | 27 | 2019 |
| Calmodulin and PI (3, 4, 5) P3 cooperatively bind to the Itk pleckstrin homology domain to promote efficient calcium signaling and IL-17A production X Wang, SE Boyken, J Hu, X Xu, RP Rimer, MA Shea, AS Shaw, ... Science signaling 7 (337), ra74-ra74, 2014 | 23 | 2014 |
| The AMPK inhibitor overcomes the paradoxical effect of RAF inhibitors through blocking phospho–Ser-621 in the C terminus of CRAF J Yuan, WH Ng, J Yap, B Chia, X Huang, M Wang, J Hu Journal of Biological Chemistry 293 (37), 14276-14284, 2018 | 21 | 2018 |
| Lsc activity is controlled by oligomerization and regulates integrin adhesion J Hu, P Strauch, A Rubtsov, EE Donovan, R Pelanda, RM Torres Molecular immunology 45 (7), 1825-1836, 2008 | 19 | 2008 |
Andrey ShawSenior Staff Scientist, GenentechDirección de correo verificada de gene.com
