Novel benzodiazepine-like ligands with various anxiolytic, antidepressant, or pro-cognitive profiles TD Prevot, G Li, A Vidojevic, KA Misquitta, C Fee, A Santrac, DE Knutson, ... Molecular neuropsychiatry 5 (2), 84-97, 2019 | 75 | 2019 |
Design and Synthesis of Novel Deuterated Ligands Functionally Selective for the γ-Aminobutyric Acid Type A Receptor (GABAAR) α6 Subtype with Improved … DE Knutson, R Kodali, B Divović, M Treven, MR Stephen, NM Zahn, ... Journal of medicinal chemistry 61 (6), 2422-2446, 2018 | 59 | 2018 |
A Novel Orally Available Asthma Drug Candidate That Reduces Smooth Muscle Constriction and Inflammation by Targeting GABAA Receptors in the Lung GS Forkuo, AN Nieman, R Kodali, NM Zahn, G Li, MS Rashid Roni, ... Molecular pharmaceutics 15 (5), 1766-1777, 2018 | 47 | 2018 |
Development of GABAA Receptor Subtype-Selective Imidazobenzodiazepines as Novel Asthma Treatments GS Forkuo, ML Guthrie, NY Yuan, AN Nieman, R Kodali, R Jahan, ... Molecular pharmaceutics 13 (6), 2026-2038, 2016 | 38 | 2016 |
Pharmacological and antihyperalgesic properties of the novel α2/3 preferring GABAA receptor ligand MP-III-024 BD Fischer, RJ Schlitt, BZ Hamade, S Rehman, M Ernst, MM Poe, G Li, ... Brain research bulletin 131, 62-69, 2017 | 37 | 2017 |
Alleviation of Multiple Asthmatic Pathologic Features with Orally Available and Subtype Selective GABAA Receptor Modulators GS Forkuo, AN Nieman, NY Yuan, R Kodali, OB Yu, NM Zahn, R Jahan, ... Molecular pharmaceutics 14 (6), 2088-2098, 2017 | 32 | 2017 |
Optimization of substituted imidazobenzodiazepines as novel asthma treatments R Jahan, MR Stephen, GS Forkuo, R Kodali, ML Guthrie, AN Nieman, ... European journal of medicinal chemistry 126, 550-560, 2017 | 30 | 2017 |
A novel GABAA receptor ligand MIDD0301 with limited blood-brain barrier penetration relaxes airway smooth muscle ex vivo and in vivo GT Yocum, JF Perez-Zoghbi, J Danielsson, AS Kuforiji, Y Zhang, G Li, ... American Journal of Physiology-Lung Cellular and Molecular Physiology 316 (2 …, 2019 | 18 | 2019 |
Design and evaluation of heterobivalent PAR1–PAR2 ligands as antagonists of calcium mobilization MW Majewski, DM Gandhi, R Rosas Jr, R Kodali, LA Arnold, ... ACS medicinal chemistry letters 10 (1), 121-126, 2018 | 17 | 2018 |
MIDD0301 – A first‐in‐class anti‐inflammatory asthma drug targets GABAA receptors without causing systemic immune suppression NM Zahn, AT Huber, BN Mikulsky, ME Stepanski, AS Kehoe, G Li, ... Basic & clinical pharmacology & toxicology 125 (1), 75-84, 2019 | 14 | 2019 |
Synthesis of chiral GABAA receptor subtype selective ligands as potential agents to treat schizophrenia as well as depression G Li, MR Stephen, R Kodali, NM Zahn, MM Poe, VVNPB Tiruveedhula, ... ARKIVOC: free online journal of organic chemistry 2018 (4), 158, 2018 | 14 | 2018 |
Attaining in vivo selectivity of positive modulation of α3βγ2 GABAA receptors in rats: A hard task! B Batinić, T Stanković, MR Stephen, R Kodali, VV Tiruveedhula, G Li, ... European Neuropsychopharmacology 28 (8), 903-914, 2018 | 6 | 2018 |
A new pharmacological approach for asthma through tissue-specific modulation of the GABA (A) receptor LA Arnold, GS Forkuo, AN Nieman, BY Olivia, ML Guthrie, NY Yuan, ... Journal of Allergy and Clinical Immunology 137 (2), AB393, 2016 | 6 | 2016 |
GABA (A) receptor modulators and methods to control airway hyperresponsiveness and inflammation in asthma AE ARNOLD, DC Stafford, JM Cook, CW Emala, G FORKUO, R JAHAN, ... | 3 | 2018 |
New oral treatments for asthma through tissue-specific modulation of the GABAA receptor L Arnold, G Forkuo, A Nieman, BY Olivia, ML Guthrie, R Kodali, N Yuan, ... Journal of Allergy and Clinical Immunology 139 (2), AB9, 2017 | 2 | 2017 |
Gaba (a) receptor modulators and methods to control airway hyperresponsiveness and inflammation in asthma AE Arnold, DC Stafford, JM Cook, CW Emala, G Forkuo, R Jahan, ... US Patent App. 17/886,403, 2023 | | 2023 |
Substituted benzo [f] imidazo [1, 5-a][1, 4] diazepines as GABA (a) receptor modulators AE Arnold, DC Stafford, JM Cook, CW Emala, G Forkuo, R Jahan, ... US Patent 11,447,495, 2022 | | 2022 |
Gaba (a) receptor modulators and methods to control airway hyperresponsiveness and inflammation in asthma AE Arnold, DC Stafford, JM Cook, CW Emala, G FORKUO, R JAHAN, ... | | 2021 |
Gaba (a) receptor modulators and methods to control airway hyperresponsiveness and inflammation in asthma AE Arnold, DC Stafford, JM Cook, CW Emala, G Forkuo, R Jahan, ... US Patent App. 16/325,080, 2021 | | 2021 |
Correction to “A Novel Orally Available Asthma Drug Candidate That Reduces Smooth Muscle Constriction and Inflammation by Targeting GABAA Receptors in the … GS Forkuo, AN Nieman, R Kodali, NM Zahn, G Li, MSR Roni, MR Stephen, ... Molecular Pharmaceutics 16 (11), 4756-4756, 2019 | | 2019 |