| Somatic activating mutations in Pik3ca cause sporadic venous malformations in mice and humans SD Castillo, E Tzouanacou, M Zaw-Thin, IM Berenjeno, VER Parker, ... Science translational medicine 8 (332), 332ra43-332ra43, 2016 | 170 | 2016 |
| The SOX family of genes in cancer development: biological relevance and opportunities for therapy SD Castillo, M Sanchez-Cespedes Expert opinion on therapeutic targets 16 (9), 903-919, 2012 | 144 | 2012 |
| The SRY-HMG box gene, SOX4, is a target of gene amplification at chromosome 6p in lung cancer PP Medina, SD Castillo, S Blanco, M Sanz-Garcia, C Largo, S Alvarez, ... Human molecular genetics 18 (7), 1343-1352, 2009 | 131 | 2009 |
| Novel transcriptional targets of the SRY-HMG box transcription factor SOX4 link its expression to the development of small cell lung cancer SD Castillo, A Matheu, N Mariani, J Carretero, F Lopez-Rios, ... Cancer research 72 (1), 176-186, 2012 | 101 | 2012 |
| Blockade of VEGF-C signaling inhibits lymphatic malformations driven by oncogenic PIK3CA mutation I Martinez-Corral, Y Zhang, M Petkova, H Ortsäter, S Sjöberg, SD Castillo, ... Nature communications 11 (1), 2869, 2020 | 65 | 2020 |
| Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling IM Berenjeno, R Piñeiro, SD Castillo, W Pearce, N McGranahan, ... Nature communications 8 (1), 1773, 2017 | 65 | 2017 |
| Behavioural immune landscapes of inflammation G Crainiciuc, M Palomino-Segura, M Molina-Moreno, J Sicilia, ... Nature 601 (7893), 415-421, 2022 | 59 | 2022 |
| Endothelial cell rearrangements during vascular patterning require PI3-kinase-mediated inhibition of actomyosin contractility A Angulo-Urarte, P Casado, SD Castillo, P Kobialka, MP Kotini, ... Nature communications 9 (1), 4826, 2018 | 56 | 2018 |
| PIK3CA mutations in vascular malformations SD Castillo, E Baselga, M Graupera Current Opinion in Hematology 26 (3), 170-178, 2019 | 48 | 2019 |
| Gene amplification of the transcription factor DP1 and CTNND1 in human lung cancer SD Castillo, B Angulo, A Suarez‐Gauthier, L Melchor, PP Medina, ... The Journal of pathology 222 (1), 89-98, 2010 | 41 | 2010 |
| Angiocrine polyamine production regulates adiposity E Monelli, P Villacampa, A Zabala-Letona, A Martinez-Romero, J Llena, ... Nature Metabolism 4 (3), 327-343, 2022 | 39 | 2022 |
| Determining the profiles and parameters for gene amplification testing of growth factor receptors in lung cancer E Pros, S Lantuejoul, L Sanchez‐Verde, SD Castillo, E Bonastre, ... International journal of cancer 133 (4), 898-907, 2013 | 30 | 2013 |
| Phosphoinositide 3‐kinase: a new kid on the block in vascular anomalies SD Castillo, B Vanhaesebroeck, NJ Sebire The Journal of pathology 240 (4), 387-396, 2016 | 24 | 2016 |
| The onset of PI3K‐related vascular malformations occurs during angiogenesis and is prevented by the AKT inhibitor miransertib P Kobialka, H Sabata, O Vilalta, L Gouveia, A Angulo‐Urarte, L Muixí, ... EMBO Molecular Medicine 14 (7), e15619, 2022 | 19 | 2022 |
| Immune-interacting lymphatic endothelial subtype at capillary terminals drives lymphatic malformation M Petkova, M Kraft, S Stritt, I Martinez-Corral, H Ortsäter, M Vanlandewijck, ... Journal of Experimental Medicine 220 (4), e20220741, 2023 | 15 | 2023 |
| Low dose AKT inhibitor miransertib cures PI3K-related vascular malformations in preclinical models of human disease P Kobialka, H Sabata, O Vilalta, A Angulo-Urarte, L Muixí, J Zanoncello, ... bioRxiv, 2021.07. 16.452617, 2021 | 3 | 2021 |
| Immunoregulatory subtype of dermal lymphatic endothelial cells at capillary terminals drives lymphatic malformations M Petkova, M Kraft, S Stritt, I Martinez-Corral, H Ortsäter, Y Sun, ... bioRxiv, 2022.05. 22.492950, 2022 | 1 | 2022 |
| New genetic drivers in hemorrhagic hereditary telangiectasia P Cerdà, SD Castillo, C Aguilera, A Iriarte, JL Rocamora, AM Larrinaga, ... European Journal of Internal Medicine 119, 99-108, 2024 | | 2024 |
| Genética Médica News SD Castillo, P Castel | | |
Lorenzo MelchorPolicy Analyst, Joint Research Centre, European CommissionDirección de correo verificada de ec.europa.eu
