Wiep Klaas Smits

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	All	Since 2016
Citations	3579	1780
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O.P. KuipersUniversity of GroningenVerified email at rug.nl
Jan-Willem VeeningProfessor, Department of Fundamental Microbiology, University of LausanneVerified email at unil.ch
Leendert HamoenProfessor, Bacterial Cell Biology, Swammerdam Institute for Life Sciences (SILS), University ofVerified email at uva.nl
Alan D GrossmanMassachusetts Institute of TechnologyVerified email at mit.edu
Hilary P Brownewellcome trust sanger instituteVerified email at sanger.ac.uk
Trevor D LawleyWellcome Trust Sanger InstituteVerified email at sanger.ac.uk
Akos T KovacsTechnical University of Denmark/Department of Biotechnology and BiomedicineVerified email at dtu.dk
Jeroen FrankPhD student, Department of Microbiology, Radboud University NijmegenVerified email at science.ru.nl
Yahya AnvarDept. Human Genetics & Dept. Clinical Pharmacy and Toxicology, Leiden University Medical CenterVerified email at lumc.nl
Matthew GreenBioinformatician, The European Bioinformatics InstituteVerified email at ebi.ac.uk
ines mandic mulecProfessor of Microbiology, University of LjubljanaVerified email at bf.uni-lj.si
Linh HoCalifornia Northstate UniversityVerified email at cnsu.edu
Robert FaganSenior Lecturer, Dept. of Molecular Biology and Biotechnology, University of SheffieldVerified email at sheffield.ac.uk
Harry J FlintRowett Institute of Nutrition and Health, University of Aberdeen, UKVerified email at abdn.ac.uk
Sylvia DuncanRowett Institute, U. of AberdeenVerified email at abdn.ac.uk
Lars BarquistHelmholtz Institute for RNA-based Infection ResearchVerified email at helmholtz-hiri.de
J.D.H. JongbloedPrincipal Investigator, clinical laboratoy geneticist, Department of Genetics, University Medical Center Groningen, University oVerified email at umcg.nl
EJ BlomResearcher Lead Discovery KeygeneVerified email at keygene.com
HOURA MERRIKHVanderbilt UniversityVerified email at vanderbilt.edu
Jean-Yves F. DuboisVerified email at bbox.fr

Wiep Klaas Smits

Assistant Professor/Principal Investigator, Leiden University Medical Center

Verified email at lumc.nl - Homepage

Microbiology Genetics Cell Biology Biochemistry Biophysics


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Bistability, epigenetics, and bet-hedging in bacteria JW Veening, WK Smits, OP Kuipers Annu. Rev. Microbiol. 62, 193-210, 2008	937	2008
Phenotypic variation in bacteria: the role of feedback regulation WK Smits, OP Kuipers, JW Veening Nature Reviews Microbiology 4 (4), 259-271, 2006	524	2006
PrimeView Clostridium difficile infection WK Smits, D Lyras, DB Lacy, MH Wilcox, EJ Kuijper Nature Reviews Disease Primers 16021, 1, 2016	318*	2016
Clostridium difficile infection WK Smits, D Lyras, DB Lacy, MH Wilcox, EJ Kuijper Nature Reviews Disease Primers 16020, 1-20, 2016	318	2016
Stripping Bacillus: ComK auto‐stimulation is responsible for the bistable response in competence development WK Smits, CC Eschevins, KA Susanna, S Bron, OP Kuipers, LW Hamoen Molecular microbiology 56 (3), 604-614, 2005	223	2005
Improving the predictive value of the competence transcription factor (ComK) binding site in Bacillus subtilis using a genomic approach LW Hamoen, WK Smits, A Jong, S Holsappel, OP Kuipers Nucleic acids research 30 (24), 5517-5528, 2002	144	2002
Genome2D: a visualization tool for the rapid analysis of bacterial transcriptome data RJS Baerends, WK Smits, A de Jong, LW Hamoen, J Kok, OP Kuipers Genome biology 5 (5), 1-6, 2004	101	2004
The Rok protein of Bacillus subtilis represses genes for cell surface and extracellular functions M Albano, WK Smits, LTY Ho, B Kraigher, I Mandic-Mulec, OP Kuipers, ... Journal of Bacteriology 187 (6), 2010-2019, 2005	90	2005
Single cell analysis of gene expression patterns of competence development and initiation of sporulation in Bacillus subtilis grown on chemically defined media JW Veening, WK Smits, LW Hamoen, OP Kuipers Journal of applied microbiology 101 (3), 531-541, 2006	89	2006
Functional genomics reveals that Clostridium difficile Spo0A coordinates sporulation, virulence and metabolism LJ Pettit, HP Browne, L Yu, WK Smits, RP Fagan, L Barquist, MJ Martin, ... BMC genomics 15 (1), 1-15, 2014	88	2014
Temporal separation of distinct differentiation pathways by a dual specificity Rap‐Phr system in Bacillus subtilis WK Smits, C Bongiorni, JW Veening, LW Hamoen, OP Kuipers, M Perego Molecular microbiology 65 (1), 103-120, 2007	85	2007
The transcriptional regulator Rok binds A+ T-rich DNA and is involved in repression of a mobile genetic element in Bacillus subtilis WK Smits, AD Grossman PLoS Genet 6 (11), e1001207, 2010	84	2010
TcdC does not significantly repress toxin expression in Clostridium difficile 630ΔErm D Bakker, WK Smits, EJ Kuijper, J Corver PloS one 7 (8), e43247, 2012	80	2012
Visualization of differential gene expression by improved cyan fluorescent protein and yellow fluorescent protein production in Bacillus subtilis JW Veening, WK Smits, LW Hamoen, JDH Jongbloed, OP Kuipers Applied and environmental microbiology 70 (11), 6809-6815, 2004	76	2004
Ordered association of helicase loader proteins with the Bacillus subtilis origin of replication in vivo WK Smits, AI Goranov, AD Grossman Molecular microbiology 75 (2), 452-461, 2010	67	2010
C. difficile 630Δerm Spo0A regulates sporulation, but does not contribute to toxin production, by direct high-affinity binding to target DNA KE Rosenbusch, D Bakker, EJ Kuijper, WK Smits PloS one 7 (10), e48608, 2012	61	2012
Ubiquitous late competence genes in Bacillus species indicate the presence of functional DNA uptake machineries ÁT Kovács, WK Smits, AM Mirończuk, OP Kuipers Environmental Microbiology 11 (8), 1911-1922, 2009	61	2009
Complete genome sequence of the Clostridium difficile laboratory strain 630Δerm reveals differences from strain 630, including translocation of the mobile element CTn5 E Van Eijk, SY Anvar, HP Browne, WY Leung, J Frank, AM Schmitz, ... BMC genomics 16 (1), 31, 2015	50	2015
Chromosomal replication initiation machinery of low-G+ C-content Firmicutes GS Briggs, WK Smits, P Soultanas Journal of bacteriology 194 (19), 5162-5170, 2012	50	2012
Hype or hypervirulence: A reflection on problematic C. difficile strains WK Smits Virulence 4 (7), 592-596, 2013	49	2013

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