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Wiep Klaas Smits
Wiep Klaas Smits
Associate Professor/Principal Investigator, Leiden University Medical Center
Dirección de correo verificada de lumc.nl - Página principal
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Bistability, epigenetics, and bet-hedging in bacteria
JW Veening, WK Smits, OP Kuipers
Annu. Rev. Microbiol. 62, 193-210, 2008
11972008
PrimeView Clostridium difficile infection
WK Smits, D Lyras, DB Lacy, MH Wilcox, EJ Kuijper
Nature Reviews Disease Primers 16021, 1, 2016
836*2016
Clostridium difficile infection
WK Smits, D Lyras, DB Lacy, MH Wilcox, EJ Kuijper
Nature Reviews Disease Primers 16020, 1-20, 2016
8362016
Phenotypic variation in bacteria: the role of feedback regulation
WK Smits, OP Kuipers, JW Veening
Nature Reviews Microbiology 4 (4), 259-271, 2006
6152006
Stripping Bacillus: ComK auto‐stimulation is responsible for the bistable response in competence development
WK Smits, CC Eschevins, KA Susanna, S Bron, OP Kuipers, LW Hamoen
Molecular microbiology 56 (3), 604-614, 2005
2542005
Improving the predictive value of the competence transcription factor (ComK) binding site in Bacillus subtilis using a genomic approach
LW Hamoen, WK Smits, A Jong, S Holsappel, OP Kuipers
Nucleic acids research 30 (24), 5517-5528, 2002
1652002
Functional genomics reveals that Clostridium difficileSpo0A coordinates sporulation, virulence and metabolism
LJ Pettit, HP Browne, L Yu, WK Smits, RP Fagan, L Barquist, MJ Martin, ...
BMC genomics 15, 1-15, 2014
1582014
The Transcriptional Regulator Rok Binds A+T-Rich DNA and Is Involved in Repression of a Mobile Genetic Element in Bacillus subtilis
WK Smits, AD Grossman
PLoS genetics 6 (11), e1001207, 2010
1232010
Genome2D: a visualization tool for the rapid analysis of bacterial transcriptome data
RJS Baerends, WK Smits, A de Jong, LW Hamoen, J Kok, OP Kuipers
Genome Biology 5, 1-6, 2004
1212004
TcdC Does Not Significantly Repress Toxin Expression in Clostridium difficile 630ΔErm
D Bakker, WK Smits, EJ Kuijper, J Corver
Public Library of Science 7 (8), e43247, 2012
1042012
The Rok Protein of Bacillus subtilis Represses Genes for Cell Surface and Extracellular Functions
M Albano, WK Smits, LTY Ho, B Kraigher, I Mandic-Mulec, OP Kuipers, ...
Journal of bacteriology 187 (6), 2010-2019, 2005
1042005
Temporal separation of distinct differentiation pathways by a dual specificity Rap‐Phr system in Bacillus subtilis
WK Smits, C Bongiorni, JW Veening, LW Hamoen, OP Kuipers, M Perego
Molecular microbiology 65 (1), 103-120, 2007
1032007
Mechanistic insights in the success of fecal microbiota transplants for the treatment of Clostridium difficile infections
A Baktash, EM Terveer, RD Zwittink, BVH Hornung, J Corver, EJ Kuijper, ...
Frontiers in microbiology 9, 387843, 2018
1012018
Plasmid-mediated metronidazole resistance in Clostridioides difficile
IM Boekhoud, BVH Hornung, E Sevilla, C Harmanus, IMJG Bos-Sanders, ...
Nature communications 11 (1), 598, 2020
992020
C. difficile 630Δerm Spo0A regulates sporulation, but does not contribute to toxin production, by direct high-affinity binding to target DNA
KE Rosenbusch, D Bakker, EJ Kuijper, WK Smits
PloS one 7 (10), e48608, 2012
952012
Single cell analysis of gene expression patterns of competence development and initiation of sporulation in Bacillus subtilis grown on chemically defined media
JW Veening, WK Smits, LW Hamoen, OP Kuipers
Journal of applied microbiology 101 (3), 531-541, 2006
942006
DNA replication proteins as potential targets for antimicrobials in drug-resistant bacterial pathogens
E van Eijk, B Wittekoek, EJ Kuijper, WK Smits
Journal of Antimicrobial Chemotherapy 72 (5), 1275-1284, 2017
912017
Ordered association of helicase loader proteins with the Bacillus subtilis origin of replication in vivo
WK Smits, AI Goranov, AD Grossman
Molecular microbiology 75 (2), 452-461, 2010
872010
Complete genome sequence of the Clostridium difficile laboratory strain 630Δ erm reveals differences from strain 630, including translocation of the mobile element CTn 5
E Van Eijk, SY Anvar, HP Browne, WY Leung, J Frank, AM Schmitz, ...
BMC genomics 16, 1-14, 2015
782015
Visualization of Differential Gene Expression by Improved Cyan Fluorescent Protein and Yellow Fluorescent Protein Production in Bacillus subtilis
JW Veening, WK Smits, LW Hamoen, JDH Jongbloed, OP Kuipers
Applied and environmental microbiology 70 (11), 6809-6815, 2004
782004
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Artículos 1–20